Li-jun Peng, Jin-sheng Guo, Zhe Zhang, Li-li Liu, Yi-rong Cao, Hong Shi, Jian Wang, Scott L. Friedman, John J. Sninsky and Ji-yao Wang
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neoplastic cells [ 28 ].
Other studies have reported that high expression of chemokine receptors may be necessary to activate cancer progressing signals. For instance, advanced aggressive PC cells express higher levels of CCR2 compared to less-aggressive gland cells, and they also show increase in metastatic capacity compared to localized PC [ 33 ]. Furthermore, increased CXCL8 and CCL2 levels in serum have been shown to be potential prognostic markers of a highly progressive PC [ 34 , 35 ]. Therefore, the role of chemokines in PC is very significant.