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Effect of pentoxifylline on histological activity and fibrosis of nonalcoholic steatohepatitis patients: A one year randomized control trial

NASH. Only few studies and pilot trials of PTX[ 14 - 16 ] suggested that pentoxifylline reduced plasma TNF- α and IL-6, ALT and AST levels but there is scarcity of data to observe improvement of NAFLD activity score (NAS) and fibrosis score in patients with nonalcoholic steatohepatitis (NASH). The aim of this study was to observe the effect of pentoxifylline on histological activity and fibrosis of Bangladeshi nonalcoholic steatohepatitis patients. Materials and methods This study was conducted from August 2014 to December 2015 as an open label Randomized

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Upper gastrointestinal bleeding in patients with end stage renal disease: causes, characteristics and factors associated with need for endoscopic therapeutic intervention

dysfunction and increased risk of vascular malformation. [ 2 ] Since GI diseases are common in ESRD patients, multiple studies have been conducted to study the endoscopic findings in this population. Most common reason for endoscopic evaluation has been UGIB. [ 2 , 4 ] Several scoring systems have also been developed to classify patients with UGIB according to their outcome. One such scoring system is the Glasgow Blatchford bleeding Score (GBS), a well-established tool to stratify patients in dire need of intervention from UGIB on the basis of their history, physical

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Correlation between MELD and UNa/K ratio in predicting renal dysfunction in cirrhotic patients

Stage Liver Disease (MELD) is a validated chronic liver disease (CLD) severity scoring system that includes serum bilirubin, serum creatinine, and the international normalized ratio (INR). An increasing MELD score is associated with progression of hepatic dysfunction, severity and three-month mortality risk.[ 5 ] MELD is also used to prioritize patients on liver transplant waiting list. It is considered better than the Child-Turcotte-Pugh (CTP) score, in part, because of the inclusion of creatinine, which reflects the prognostic impact of renal function.[ 6

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Effect of weight reduction on histological activity and fibrosis of lean nonalcoholic steatohepatitis patient

progression to cirrhosis or hepatocellular carcinoma (HCC). At present, the resolution of the histological findings of NASH is now approved as a surrogate endpoint. The major treatment offered for NAFLD remains lifestyle changes including weight reduction by a healthy diet and performing regular physical activity. [ 12 , 13 ] It is evident that improvements of liver histology in NASH can be achieved through losing a certain amount of weight. [ 14 ] Promrat et al . in his RCT showed that almost 7–10% of weight reduction can improve the NAFLD activity score (NAS) and its

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Metabolic acidosis status and mortality in patients on the end stage of renal disease

coronary heart disease is the Framingham risk score (FRS). According to the National Institutes of Health, the patients having chronic kidney disease are considered as having a coronary heart disease risk equivalent, meaning that they are primarily patients with a 10-year risk for myocardial infarction or coronary death >20%, despite without known coronary heart disease. [ 8 ] Metabolic acidosis, a common condition and an important manifestation of the late stage of chronic kidney disease, leads to clinically significant consequences, including bone disease disorders

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The role of calprotectin in rheumatoid arthritis

) score serves as another clinical joint damage index. It was reported that CLP levels were positively relevant to RAAD score rather than CRP or ESR levels. [ 54 ] Nevertheless, it was still contradictory whether CLP was related to anticitrullinated peptide antibodies titers. [ 3 , 50 ] Association between serum CLP and disease activity of RA has been confirmed in recent years. Circulating CLP levels are high in active RA [ 2 ] and are significantly related to Disease Activity Score based on a 28-joint count (DAS28), simplified Disease Activity Index (SDAI) and

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Treatment of ventilator-associated pneumonia with high-dose colistin under continuous veno-venous hemofiltration

in all patients: age, gender, Acute Physiology and Chronic Health Evaluation (APACHE) II score, Sequential Organ Failure Assessment (SOFA) score, comorbidities, concomitant antibiotic therapy, body mass index, and type/MIC of the causative pathogen. Occurrence of acute kidney injury (AKI) was assessed based on serum creatinine values recorded before the start of CVVH, 2 days after withdrawing CVVH, and at hospital discharge in survivors. Values were stratified according to the Kidney Disease Improving Global Outcomes (KDIGO) criteria and duration of COL therapy

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Hepatic encephalopathy in patients in Lviv (Ukraine)

, lethargy, impaired intellectual ability, and so on in end-stage coma (with or without response to stimuli) and later death in severe cases. [ 4 , 5 , 6 , 7 ] The neuropsychological peculiarity can be revealed by the use of psychometric tests, for instance, neuropsychological tests such as Halstead-Reitan (H-R) score and Child-Pugh score or other psychometric tests. [ 8 , 9 , 10 ] There is no gold standard test to diagnose HE due to the personal peculiarities of each case. That is why physicians mostly rely on their personal experiences, equipment availability, and

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Role of hepatokines in non-alcoholic fatty liver disease

Srishord M Fukui N The Global Epidemiology of NAFLD and NASH in Patients with type 2 diabetes: A Systematic Review and Meta-analysis J Hepatol 2019 71 793 801 3 Rinella ME. Nonalcoholic fatty liver disease: a systematic review. JAMA 2015;313:2263–73. 10.1001/jama.2015.5370 26057287 Rinella ME Nonalcoholic fatty liver disease: a systematic review JAMA 2015 313 2263 73 4 Kleiner DE, Brunt EM, Van Natta M, Behling C, Contos MJ, Cummings OW, et al . Design and validation of a histological scoring system for nonalcoholic fatty

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Electroencephalographic abnormalities in sepsis patients in correlation to the calculated prognostic scores: A case series

Introduction Brain dysfunction is a frequent complication of sepsis even in cases of extra-cranial origin and is related to several underlying mechanisms. Encephalography (EEG) seems to be a useful tool in detecting the presence of encephalopathy in patients with sepsis. Although EEG is not a specific test, it is sensitive and can detect abnormalities even when clinical neurologic examination is normal. The aim of this study was to document the EEG abnormalities and search for correlations between EEG findings and commonly used severity and prognostic scores

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