Hepatitis is a global disease that is on the rise and is currently the cause of more deaths than the human immunodeficiency virus each year. As a result, there is an increasing need for antivirals. Previously, effective antivirals have been found in the form of substrate-mimetic antiviral protease inhibitors. The application of machine learning has been used to predict cleavage patterns of viral proteases to provide information for future drug design. This study has successfully applied and compared several machine learning algorithms to hepatitis C viral NS3 serine protease cleavage data. Results have found that differences in sequence-extraction methods can outweigh differences in algorithm choice. Models produced from pseudo-coded datasets all performed with high accuracy and outperformed models created with orthogonal-coded datasets. However, no single pseudo-model performed significantly better than any other. Evaluation of performance measures also show that the correct choice of model scoring system is essential for unbiased model assessment.
B. Tsai, H. Xue, E. Birgersson, S. Ollmar and U. Birgersson
anatomy 24 (3-4) (2002) 183-189. http://dx.doi.org/10.1007/s00276-002-0034-5 10.1007/s00276-002-0034-5 Lee Y. Hwang K. Skin thickness of Korean adults Surgical and radiologic anatomy 24 3-4 2002 183 – 189 http://dx.doi.org/10.1007/s00276-002-0034-5
27 Moore, M. Lunt, B. McManus, M. Anderson, A. Herrick, Seventeen-point dermal ultrasound scoring system - a reliable measure of skin thickness in patients with systemic sclerosis, Rheumatology 42 (12) (2003) 1559-1563. https://doi.org/10.1093/rheumatology/keg435 12867579 10.1093/rheumatology/keg435
Evgeni Eltzov, Abri Lavena De Cesarea, ‘Yuen Kei Adarina Low and Robert S. Marks
homes in Edmonton, Canada. Building and Environment, 2015; 90: p. 114-124.
6. Bako-Biro Z, Wargocki P, Weschler CJ,Fanger PO, Effects of pollution from personal computers on perceived air quality, SBS symptoms and productivity in offices. Indoor Air, 2004; 14(3): p. 178-187.
7. Lee SC, Chan LY,Chiu MY, Indoor and outdoor air quality investigation at 14 public places in Hong Kong. Environment International, 1999; 25(4): p. 443-450.
8. Hong T, Kim J,Lee M, Integrated task performance score for the building occupants based on the CO2 concentration and
Michael Bodo, Richard Mahon, Alex Razumovsky, Efim Kouperberg, Michael Crimmins, Rocco Armonda and Martin Baruch
visually inspected and evaluated to ascertain physiological CBF reactions. To provide a qualitative comparison of each modality's reflection of CBF AR during each test, results were entered into a spreadsheet (Microsoft Excel, Redmond, WA), where assessment scores of successful and failed tests were recorded ( Table 2 ). Artifactcontaminated data were not analyzed.
Summary of tests and responses by modalities: BH (breath holding); HV (hyperventilation); CO 2 (CO 2 inhalation); VAL: Valsalva maneuver; TREN (Trendelenburg position); R TREN (reverse
Farshid Mahmoudi, Mozafar Naserpour, Zahra Farzanegan and Amirhossein Davudian Talab
Introduction: Since the CT operators play an important role in the diagnosis and treatment of diseases and exposing the patients to radiation exposure, they must be aware of all CT parameters which affect the image quality and patient dose and update their knowledge in parallel with the progresses in CT technology. Therefore, the knowledge of radiographers and CT technologists regarding the CT parameters was assessed in this study to identify and resolve any potential deficiencies.
Material and methods: This study was conducted in 2018 among 113 radiographers and 103 CT technologists in Khuzestan province using a three-part questionnaire containing demographic characteristics, general opinion on CT scan dose and questions assessing technologists’ knowledge of CT exposure parameters. Data were analyzed using SPSS software.
Results: Total knowledge scores of radiographers and CT technologists about CT exposure parameters were 36 and 42, respectively. The highest knowledge score among technologist was the knowledge of changing parameters based on patient characteristics and the lowest was in the field of awareness of noise index and diagnostic reference levels.
Conclusion: Total knowledge scores of radiographers and CT technologists about different scan parameters affecting dose and image quality was very low. Reviewing and updating the content of academic education and holding retraining courses are suggested.
Evaluation of phoneme perception based on the digitalized phoneme test in children with cochlear implants
Early diagnosis of congenital defect of hearing poses new challenges for a multidisciplinary team of pedoaudiologists, ENT (ear-nose-throat) specialists and speech therapists. This study assessed the perception of phonemes in children with a cochlear implant and the possibilities of applying acoustical solutions in the audiologic evaluation. The participants were 17 implanted children, aged 5-9 years, who received a cochlear implant when they were from 18 months to 3 years old. Detection thresholds and discrimination score were assessed. This study also aimed at verifying the possibilities of applying the digital audioprocessing algorithm in clinical practice. The test based on the phonemes aa, uu, ii, ss, sh (Ling 5 sound test) was used. The test was modified in the frequency domain - the main aim of this modification was to improve the precision of the reconstruction of the audible threshold. The results indicated significant correlations between pure tone audiometry results and thresholds of phoneme detection [dB SPL]. The identification score in this group was 95-100% for sound pressure level 65 dB SPL.
Visualization of markers is critical for imaging modalities such as computed tomography (CT) and magnetic resonance imaging (MRI). However, the size of the marker varies according to the imaging technique. While a large-sized marker is more useful for visualization in MRI, it results in artifacts on CT and causes substantial pain on administration. In contrast, a small-sized marker reduces the artifacts on CT but hampers MRI detection. Herein, we report a new ironcontaining marker and compare its utility with that of non-iron-containing markers. Five patients underwent CT/MRI fusion-based intensity-modulated radiotherapy, and the markers were placed by urologists. A Gold Anchor™ (GA; diameter, 0.28 mm; length, 10 mm) was placed using a 22G needle on the right side of the prostate. A VISICOIL™ (VIS; diameter, 0.35 mm; length, 10 mm) was placed using a 19G needle on the left side. MRI was performed using T2*-weighted imaging. Three observers evaluated and scored the visual qualities of the acquired images. The mean score of visualization was almost identical between the GA and VIS in radiography and cone-beam CT (Novalis Tx). The artifacts in planning CT were slightly larger using the GA than using the VIS. The visualization of the marker on MRI using the GA was superior to that using the VIS. In conclusion, the visualization quality of radiography, conebeam CT, and planning CT was roughly equal between the GA and VIS. However, the GA was more strongly visualized than was the VIS on MRI due to iron containing.
Biplab Sarkar, Jyotirup Goswami, Ayan Basu and S. Sriramprasath
Paddick I. A simple scoring ratio to index the conformity of radiosurgical treatment plans. Technical note. J Neurosurg (2000) Dec;93 Suppl 3:219-22.
Narayan A, Yamada J, Berry S, et al. Intensity-modulated radiotherapy in high-grade gliomas: Clinical and Dosimetric Results. Int J Radiat Oncol Biol Phys (2006) 64;3:892-97.
Hermanto U, Frija EK, Lii M-FJ. Intensity- modulated radiotherapy (IMRT) and conventional three-dimensional conformal radiotherapy for high-grade gliomas: Does IMRT increase the integral dose to the
techniques for non-small cell lung cancer. Brit J Radiology. 1999; 72 : 279-288.
Niemierko A, Goitein M. Dose-volume distributions: a new approach to dose-volume histograms in three-dimensional treatment planning. Med Phys. 1994; 21 (1): 3-11.
Paddick I. A simple scoring ratio to index the conformity of radiosurgical treatment plans. J Neurosurg. 2000; 93 (S3): 219-222.
Knoos T, Kristensen I, Nilsson P. Volumetric and dosimetric evaluation of radiation treatment plans: Radiation
tree fuzzy rules. Int J Res Rev Comput Sci 2012; 3(3): 1659-1667.
24. Rao A, Yadu N, Pimpalwar Y, Sinha S. Utility of coronary artery calcium scores in predicting coronary atherosclerosis amongst patients with moderate risk of coronary artery disease, Journal of Indian College of Cardiology 2017; 7: 55-59.
25. Manabe O, Naya M, Tamaki N. Feasibility of PET for the management of coronary artery disease: Comparison between CFR and FFR, Journal of Cardiology 2017; 70(2): 135-140
26. Ngiam J, Coates A, Lahiri A, Prochnow B