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22. GULATI M, ARNSDORF MF, SHAW LJ, PANDEY DK, THISTED RA
Dana Pop, P. Peter, Alexandra Dădârlat, Adela Sitar-Tăut and D. Zdrenghea
Ghrelin, a newly discovered bioactive peptide, was originally reported to induce growth hormone release. Recent studies have shown beneficial hemodynamic effects of ghrelin in the cardiovascular system to support the wide distribution of its receptors in cardiovascular tissues. The aim of the study was to determine whether cardiovascular risk factors influence plasma ghrelin levels.
Methods. We evaluated in the Rehabilitation Hospital Cluj-Napoca, Cardiology - Department 88 consecutive subjects, 65 (73.86%) being women, with mean age 61.7±10.33 years. We assessed the presence of cardiovascular risk factors (obesity, arterial hypertension, diabetes mellitus, metabolic syndrome, smoking and lipid fractions). Plasma ghrelin levels were determined with a commercial ELISA kit (pg/ml).
Results. After the evaluation of cardiovascular risk factors, we found no statistically significant difference between ghrelin levels in the patients with vs those without cardiovascular risk factors (p>0.05). A negative correlation was found between ghrelin levels and age, r = −0.32 (p <0.05). Using the HeartScore Internet tool we calculated the cardiovascular risk for each patient according to the risk score system (SCORE) for high cardiovascular risk countries. Statistically, the risk of fatal cardiovascular events in the next 10 years was indirectly correlated with the ghrelin levels in each patient - correlation between ghrelin levels and SCORE system r=−0.25, p=0.015. In conclusion, low serum ghrelin concentrations are associated with an increased global cardiovascular risk, calculated based on the European SCORE scale. However, we could not demonstrate a direct relationship between any of the major risk factors and ghrelin.
Afshin Shafaghi, Faeze Gharibpoor, Zahra Mahdipour and Ali Akbar Samadani
1. SALTZMAN JR., TABAK YP., HYETT BH., SUN X., TRAVIS AC., JOHANNES RS. A simple risk score accurately predicts in-hospital mortality, length of stay, and cost in acute upper GI bleeding. Gastrointest Endosc. 2011;74(6):1215-24.
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A. Chitul, A.M. Voiosu, Mădălina Marinescu, Simona Caraiola, Adriana Nicolau, Georgeta Camelia Badea, Magda Ileana Pârvu, R. A. Ionescu, B. R. Mateescu, M. R. Voiosu, C. R. Băicuş and M. Rimbaş
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20. ORLANDO A., RENNA S., PERRICONE G., COTTONE M. Gastrointestinal lesions associated with spondyloarthropathies . World J Gastroenterol. 2009; 15( 20 ):2443-8.
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22. MIELANTS H., DE KEYSER F., BAETEN D., VAN DEN
Nicoleta Dumitru, Mara Carsote, Andra Cocolos, Eugenia Petrova, Maria Olaru, Andra Caragheorgheopol, Constantin Dumitrache and Adina Ghemigian
ML. Effect of type 2 diabetes-related non-enzymatic glycation on bone biomechanical properties . Bone. 2016; 82 :21-27.
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20. DUMITRU N., CARSOTE M., COCOLOS A., GHEMIGIAN A. Glucose metabolism indices and Trabecular Bone Score in type 2 diabetes mellitus women . 4th International Conference on Interdisciplinary Management of Diabetes Mellitus and its
Dimitrios Velissaris, Nikolaos-Dimitrios Pantzaris, Panagiotis Bountouris and Charalampos Gogos
1. STEVENSON EK, RUBENSTEIN AR, RADIN GT, WIENER RS, WALKEY AJ. Two decades of mortality trends among patients with severe sepsis: a comparative meta-analysis *. Crit Care Med 2014; 42 : 625-31.
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Stamatis Karakonstantis, Mina Koulouridi, Kyriakos Pitsillos, Eirini Kalokyri, Anna Kozyri, Galateia Gourniezaki and Charalampos Lydakis
setting . Rom J Intern Med. 2018;10.2478/rjim-2018-0039
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Elena-Daniela Grigorescu, Mariana Floria, Cristina Mihaela Lăcătușu, Bogdan Mircea-Mihai, Ioana Creţu, Alina Delia Popa, Alina Onofriescu, Irina M. Jaba, Victoriţa Șorodoc, Alexandr Ceasovschih and Laurenţiu Șorodoc
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Alana Murphy, Seth Teplitsky, Akhil K. Das, Joon Yau Leong, Andrew Margules and Costas D. Lallas
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Milica Obradovic, Zoran Gluvic, Nina Petrovic, Milan Obradovic, Ratko Tomasevic, Predrag Dugalic and Esma R. Isenovic
Introduction. Chronic liver diseases (CLD) are an important cause of morbidity and mortality in general population. The aim of this study was to analyze potential differences between patients with CLD and healthy control group, and to estimate the severity of CLD by using simple questionnaires: general health questionnaire (GHQ-12) and chronic liver disease questionnaire (CLDQ). Methods. A cross-sectional pilot study was performed in Zemun Clinical Hospital during years 2014 and 2015. Sixty participants were divided into 4 groups (15 per group): chronic alcoholic hepatitis, other chronic hepatitis, liver cirrhosis, and healthy control group. Entire study population chose one of four offered answers of structured questionnaires GHQ-12 and CLDQ, based on which mean model of end-stage liver disease (MELD) and Child-Turcotte-Pugh (CTP) scores were calculated. Results. Mean GHQ12 and CLDQ scores were 10.5 and 5.21 ± 1.11 respectively. Regarding certain CLDQ domain scores, a significant difference between alcoholic and non-alcoholic hepatitis groups in the worry domain was observed. Mean MELD score was 7.42 ± 2.89 and did not differ between chronic hepatitis groups, while mean CTP score was 5.73 ± 0.88. A statistically significant correlation was observed between GHQ12 and CLDQ scores (ρ = -0.404, p < 0.01), but not between subjective and objective scores. Conclusions. Mean GHQ12 and CLDQ scores pointed out to general psychological no-distress condition of the studied participants, as well as scarcely expressed CLD-specific complaints. Mean MELD and CTP scores indicated stable chronic liver diseases, with low three-month mortality rates in the cases of chronic hepatitis, as well as determination to Child A group in the case of liver cirrhosis.