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Advances in the treatment of acute ischemic stroke: the 2018 American Stroke Association recommendation

.1056/NEJMoa1706442 4. Puetz V et al. The Alberta Stroke Program Early CT Score in clinical practice: what have we learned?. Int J Stroke. 2009;4 (5): 354-64. doi:10.1111/j.1747-4949.2009.00337 5. Kothari RU et al. Cincinnati Prehospital Stroke Scale: reproducibility and validity. Ann Emerg Med. 1999 Apr;33(4):373-8.

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The Clinical Value of Red Blood Cell Distribution Width as a Prognosis Factor and Severity Marker in Sepsis and Septic Shock

CHARM score to predict mortality in patients with suspected sepsis. The American Journal of Emergency Medicine. 2017;35(4):640-646. 7. Kim Y, Song J, Kim E, Choi H, Jeong W, Jung I et al. A Simple Scoring System Using the Red Blood Cell Distribution Width, Delta Neutrophil Index, and Platelet Count to Predict Mortality in Patients With Severe Sepsis and Septic Shock. Journal of Intensive Care Medicine. 2018;34(2):133-139. 8. Yeh C, Chen K, Ye J, Huang C. Derivation of a clinical prediction rule for bloodstream infection mortality of patients visiting the

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Atrial Fibrillation a Benign Condition? Quality of Life Approach

Abstract

Introduction: Atrial fibrillation (AF) is the most frequent cardiac rhythm disorder, considered until recently benign. Due to its major complications (cardio-embolic episodes) patients need to be anticoagulated. Aim: To assess the quality of life (QOL) in patients with new oral anticoagulants (NOAC) versus those using classical anticoagulants (VKA). Methods: A total of 483 patients admitted consecutively in our clinic were evaluated during hospitalization and after discharge. Follow-up visits were conducted: at baseline, 6, 12, 18 and 24 months; the quality of life (QoL) was measured by a specific questionnaire (EQ-5D-3L), and the results were assessed. Patients were divided in two groups considering their anticoagulant use: NOAC or VKA. Baseline characteristics, clinical outcomes as well as QoL indices were compared between the two groups The current research has been conducted in accordance with the ethical prin ciples set out in the Helsinki Declaration and Good Clinical Practice Recommendations and was approved by our hospital Ethics Committee. Results: The mean age of our studied group (374 eligible patients) was 64.7 ± 8.2 years (p=0.220); 116 patients (31.01%) used NOAC. Patients with NOAC obtained better results in all domains: physical (57.0±8.9 vs. 51.1±12.5 vs. 42.0±6.2; p<0.001), social (62.6±19.8 vs. 52.5±20.0 vs. 45.7±16.0; p=0.019) and environmental (62.9±12.7 vs. 52.7±7.6 vs. 60.7±3.6; p =0.018). Compared to VKAs, NOACs were more commonly prescribed in patients with a history of stroke or with a higher thromboembolic risk (p<0.001). EQ-5D-3L total score: 75.6 ± 20.9; visual analogue scale: 63.1 ± 20.6. Conclusion(s): Satisfaction and QoL with oral anticoagulants were high, although they were both better with NOACs. A worse QoL was associated with comorbidities, polypragmasy, and previous treatment with VKA. Patients strongly expressed their desire to improve their QoL.

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Recurrent Wheezing

preschool children: an evidence-based approach. Eur Respir J 2008;32:1096-1110 11. Hyvarinen MK, Kotaniemi-Syrjanen A, Reijonen TM, Korhonen K, Korppi MO. Teenage asthma after severe early childhood wheezing: an 11-year prospective followup. Pediatr Pulmonol 2005;40:316- 323 12. Martinez FD. Genes, environments, development and asthma: a reappraisal. Eur Respir J 2007;29:179-184 13. Eysink PE, ter Riet G, Aalberse RC, et al. Accuracy of specific IgE in the prediction of asthma: development of a scoring formula for general

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Procedural Sedation and Analgesia in Adults - new trends in patients safety

Report of the Pediatric Sedation Research Consortium. Anesthesiology. 2016; 124(1):80-8 48. Green SM, Mason KP, Krauss BS. Pulmonary aspiration during procedural sedation: a comprehensive systematic review. BJA. 2017; 118(3):344-354 49. Trevisani L, Cifala V, Gilli G, Matarese V, Zelante A, Sartori S. Post-Anaesthetic Discharge Scoring System to assess patient recovery and discharge after colonoscopy. World Journal of Gastrointestinal Endoscopy.2013; 5(10):502-507. 50. Hickey N, O’Leary M, Falk V, Borgaonkar M. When it it safe to discharge patients

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Procedural Sedation and Analgesia in Adults - new trends in patients safety

Relationship to Nil per Os Status in Pediatric Sedation/Anesthesia Outside the Operating Room: A Report of the Pediatric Sedation Re­search Consortium. Anesthesiology. 2016; 124(1):80-8 48. Green SM, Mason KP, Krauss BS. Pulmo­nary aspiration during procedural sedation: a comprehensive systematic review. BJA. 2017; 118(3):344-354 49. Trevisani L, Cifala V, Gilli G, Matarese V, Zelante A, Sartori S. Post-Anaesthetic Dis­charge Scoring System to assess patient recovery and discharge after colonoscopy. World Journal of Gastrointestinal Endosco

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Pharmacological therapies for acute respiratory distress syndrome

]. UpToDate. 2019. Available from: https://www.uptodate.com/contents/acute-respiratory-distress-syndrome-prognosis-and-outcomes-in-adults/ 11. Bellani G, Laffey JG, Pham T, Fan E, Bro-chard L, Esteban A, et al. Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries. JAMA. 2016;315(8):788–800. 12. Gajic O, Dabbagh O, Park PK, Adesanya A, Chang SY, Hou P, et al. Early identification of patients at risk of acute lung injury: evaluation of lung injury prediction score in a

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