and toxic epidermal necrolysis. Australas J Dermatol 1999;40:131-4. 22. French LE, Prins C. Erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis. In: Bolognia JL, ed. Dermatology. 2nd ed. St. Louis: Elsevier; 2008. p. 287-300. 23. Bastuji-Garin S, Fouchard N, Bertocchi M, et al. SCORTEN: a severity-of-illness score for toxic epidermal necrolysis. J Invest Dermatol 2000;115:149-53. 24. Trent JT, Kirsner RS, Romanelli P, Kerdel FA. Use ofSCORTEN to accurately predict mortality in patients with
Metka Adamič, Miloš D. Pavlović, Miroslav Stamenković and Dane Nenadić
and health-related quality of life. Health Expect 1999;2:93-104. 9. Conroy FJ, Venus M, Monk B. A qualitative study to assess the effectiveness of laser epilation using a quality-of-life scoring system. Clin Exp Dermatol 2006;31:753-6.
Ivan Kuhajda, Miloš Koledin, Dejan Đurić, Milorad Bijelović, Mišel Milošević, Dejan Ilinčić and Miroslav Ilić
Primary hyperhidrosis affects approximately 3% of the world’s population, particularly young female adults. It is defined as excessive, profuse sweating of the palms, soles, armpits and face. Conservative treament includes diverse modalities, however, surgical treatment has shown the best long-term results. The objective of this study was to assess some disease-specific epidemiological characteristics in a pre-selected group of patients seeking surgical therapy, as well as outcomes of thoracoscopic sympathectomy. The severity and impact of hypehidrosis was assessed, using Hyperhidrosis Disease Severity Scale (HDSS: patients rate the serverity of symptoms on a scale from 1 to 4). Thoracoscopic sympathectomy was performed using a double lumen endotracheal tube, via bilateral 5 mm dual port videothoracoscopic camera 0°, and an endoscopic ultrasound activated harmonic scalpel. The sympathetic chain was resected on both sides at the level of the second and the third thoracic ganglion (T2 and T3), using an ultrasound knife. The extirpated chain was also at the level T3-T4 and sent for ex tempore analysis. There were 162 patients undergoing thoracoscopic sympathectomy: 39.51% were males and 60.49% females; at presentation their mean age (± SD) was 30.5 (±8.3), range 16 - 58 years. Axillary hyperhidrosis occurs later than palmar-axillary-plantar (p<0.05). A total of 35.18% of the evaluated patients were able to name at least one member of their families who also suffered from hyperhidrosis. The most commonly affected area was palmar-axillary-plantar (30.25%). Fifty patients (30.86%) received conservative therapy before surgery. The most commonly used conservative therapy modalities included different kinds of ointments/tinctures (11.73%), botox (8.02%) and iontophoresis (2.47%). Prior to surgery, 91.36% of patients reported severe sweating (HDSS score 3 or 4). The highest mean score was given for a combination of facial-palmar-axillaryplantar hyperhidrosis (3.80±0.24). All surgeries were successfully performed, with no complications, or perioperative morbidity. The mean hospital stay was 1.28±0.68 days long. After surgery, 93.21% of patients reported mild or moderate hyperhidrosis (HDSS score 1 or 2). Compensatory sweating (lower part of the back, and abdomen) was reported by 34.57% of patients after the surgery. All patients had a 6-months long follow-up: a significant improvement in quality of life was reported by 84.56% of patients (Yates corrected c2 (1) = 228.42; p=0.0000)); due to compensatory sweating, only 4.94% and 1.85% of patients reported bad and very bad quality of life, respectively.
In conclusion, nowadays videothoracoscopic sympathectomy is a standard treatment for primary hyperhidrosis with a high success rate.
Svetlana Popadić, Zorica Ramić, Ljiljana Medenica, Vera Pravica and Dušan Popadić
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Svetlana Popadić, Mirjana Gajić-Veljić, Sonja Prćić, Željko Mijušković, Dragan Jovanović, Lidija Kandolf-Sekulović and Miloš Nikolić
Abbreviations AD – Atopic dermatitis EASI - Eczema area and severity index FTU -“finger-tip unit” JAK - Janus kinase MTX - Methotrexate nbUVB - Narrow-band UVB PDE4 - phosphodiesterase 4 SCORAD - Scoring atopic dermatitis Th - T helper TCS - Topical corticosteroids TCI - Topical calcineurin inhibitors UVA - Ultraviolet A rays UVB - Ultraviolet B rays References: 1. Wollenberg A, Oranje A, Deleuran M, Simon D, Szalai Z, Kunz B, et al. ETFAD/EADV Eczema task force 2015 position paper on diagnosis and treatment of atopic
Danijela D. Dobrosavljević, Dimitrije Brašanac, Silvana Lukić and Ljiljana Medenica
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Sonja Prćić, Verica Đuran and Dragan Katanić
;6:204-32. 42. Prćić S, Đurović D, Đuran V, Vuković D, Gajinov Z. Neke psihološke karakteristike adolescenata sa vitiligom: naši rezultati. Med Pregl 2006;59(5-6):265-9. 43. Valkova S, Trashlieva M, Christova P. Treatment of vitiligo with local khellin and UVA: comparasion with systemic PUVA. Clin Exp Dermatol 2004;29:180-4. 44. Hamzawi I, Jain H, McLean D, Shapiro J, Zeng H, Lui H. Parametric modeling of narrow-band UVB fototherapy for vitiligo ussing a novel quantitative tool: the Vitiligo Area Scoring Index. Arch Dermatol 2004