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Open access

Tomaz Jagric, Bojan Ilijevec, Vaneja Velenik, Janja Ocvirk and Stojan Potrc

) chemotherapy. Therefore, we conducted an analysis with propensity score matched patients to determine the role of perioperative and adjuvant chemotherapy in patients after D2 lymphadenectomy. Patients and methods Patients Since 1991, 1563 patients were operated for gastric cancer in the department for Abdominal and General Surgery at the University Clinical Centre Maribor, Slovenia. The demographic characteristics of patients, the characteristics of the surgical procedures, and the pathological characteristics of tumours were prospectively stored on a computer

Open access

Satoshi Nagano, Yuhei Yahiro, Masahiro Yokouchi, Takao Setoguchi, Yasuhiro Ishidou, Hiromi Sasaki, Hirofumi Shimada, Ichiro Kawamura and Setsuro Komiya

Abstract

Background. The utility of ultrasound imaging in the screening of soft-part tumours (SPTs) has been reported. We classified SPTs according to their blood flow pattern on Doppler ultrasound and re-evaluated the efficacy of this imaging modality as a screening method. Additionally, we combined Doppler ultrasound with several values to improve the diagnostic efficacy and to establish a new diagnostic tool.

Patients and methods. This study included 189 cases of pathologically confirmed SPTs (122 cases of benign disease including SPTs and tumour-like lesions and 67 cases of malignant SPTs). Ultrasound imaging included evaluation of vascularity by colour Doppler. We established a scoring system to more effectively differentiate malignant from benign SPTs (ultrasound-based sarcoma screening [USS] score).

Results. The mean scores in the benign and malignant groups were 1.47 ± 0.93 and 3.42 ± 1.30, respectively. Patients with malignant masses showed significantly higher USS scores than did those with benign masses (p < 1 × 10-10). The area under the curve was 0.88 by receiver operating characteristic (ROC) analysis. Based on the cut-off value (3 points) calculated by ROC curve analysis, the sensitivity and specificity for a diagnosis of malignant SPT was 85.1% and 86.9%, respectively.

Conclusions. Assessment of vascularity by Doppler ultrasound alone is insufficient for differentiation between benign and malignant SPTs. Preoperative diagnosis of most SPTs is possible by combining our USS score with characteristic clinical and magnetic resonance imaging findings.

Open access

Matjaz Vrtovec, Ajda Anzic, Irena Preloznik Zupan, Katja Zaletel and Ales Blinc

plaques, which were defined as focal lesions exceeding the intima-media thickness by at least 50% or reaching an absolute thickness of at least 1.5 mm in two orthogonal projections. Scoring of atherosclerotic plaques was performed by a modification of the methodology used in the Rotterdam Study. 24 The extracranial carotid arteries were divided into three sectors on each side: the common carotid artery and its bulb, the internal carotid artery, and the external carotid artery. At least one plaque in any sector was scored 1 point, while the absence of plaques was scored

Open access

Savvas Papadopoulos, Petroula Arapantoni-Dadioti, Konstantinos Sfikas, Artemis Stylianidou, Helen Trichia, Eleftheria Katsamagou, Vaia Baleki and Johannes Noe

.120/ JCO.2002.09.094 [25] Lal P, Salazar PA, Hudis CA, Ladanyi M, Chen B (2004) HER-2 testing in breast cancer using immunohistochemical analysis and fuorescence in situ hybridization: a single-institution experience of 2,279 cases and comparison of dual-color and single-color scoring. Am J Clin Pathol 121:631– 636. doi: 10.1309/VE78-62V2-646B-R6EX [26] Perez EA, Suman VJ, Davidson NE, Martino S, Kaufman PA, Lingle WL, Flynn PJ, Ingle JN, Visscher D, Jenkins RB (2006) HER2 testing by local, central, and reference laboratories in specimens from the North Central

Open access

Arpad Ivanecz, Bojan Krebs, Andraz Stozer, Tomaz Jagric, Irena Plahuta and Stojan Potrc

study was to compare the surgical and oncological outcomes of patients undergoing simultaneous resection of primary colorectal cancer and SCLM by laparoscopic or open surgery using propensity score matching. Patients and methods Patient selection and study design All patients with SCLM were discussed by the multidisciplinary team. Treatment decisions were based on location and complexity of resection of the primary tumor, extent of liver resection, liver function and physical condition of the patients. The policy of the institution is not to combine a

Open access

Dorota Link-Lenczowska and Tomasz Sacha

skal prognostycznych należą: Międzynarodowy Wskaźnik Prognostyczny ( International Prognostic Scoring System – IPSS) [ 3 ] oraz dynamiczny IPSS ( Dynamic IPSS – DIPSS) ( Tab. I ) [ 4 ]. Pierwszy z nich stosowany jest u chorych na PMF w chwili rozpoznania, jego odmiana dynamiczna natomiast przeznaczona jest do oceny ryzyka u chorych w dowolnej chwili trwania choroby. Każdy z tych modeli prognozuje całkowity czas przeżycia pacjentów w oparciu o parametry kliniczne, których analiza pozwala na przydzielenie chorych, zgodnie z rekomendacjami IWG-MRT ( International

Open access

Mokhtar M Galila, Ebeid FS Fatma, Ishak AI Sherif, Ragab A Iman and Yousef AS Khaled

censored on last known date they were alive. Functional status was assessed by using Musculoskeletal Tumour Society Score (MSTS score) [ 11 ]. This MSTS score was established on six items each for upper and lower extremities. Each item was allocated a value from zero to five points, with five demonstrating the best function. The values form each items was added and then the functional score will be presented as a percentage of the maximum possible thirty points score. The MSTS score was then categorised into four categories; poor if less than 25%; fair if from 25% to

Open access

Ji Chen, Yong Zhao, Xin Li, Peng Sun, Muwen Wang, Ridong Wang and Xunbo Jin

Imaging primary prostate cancer with 11C-Choline PET/CT: relation to tumour stage, Gleason score and biomarkers of biologic aggressiveness

Background. As a significant overlap of 11C-Choline standardized uptake value (SUV) between prostate cancer and benign prostate hyperplasia (BPH) tissue, controversy exists regarding the clinical value of 11C-Choline PET/CT scan in primary prostate cancer. In this study, the SUVmax of the prostate lesions and the pelvic muscles were measured and their ratios (SUVmax-P/M ratio) were calculated. Then we evaluated whether the tracer 11C-Choline uptake, quantified as SUVmax-P/M ratio, correlated with tumour stage, Gleason score, and expression levels of several biomarkers of aggressiveness.

Methods. Twenty-six patients with primary prostate cancer underwent 11C-Choline PET/CT. Tumour specimens from these patients were graded histopathologically, and immunnohistochemistry for Ki-67, CD31, androgen receptor (AR), Her-2/neu, Bcl-2, and PTEN were performed.

Results. Both SUVmax and SUVmax-P/M ratio showed no significant difference between patients with tumour stage II and III, but significantly elevated in patients with tumour stage IV. SUVmax-P/M ratio was also significantly higher in lesions with Gleason score of 4+3 or higher versus less than or equal to 3+4. SUVmax-P/M ratio was found significantly correlated with expression levels of Ki-67 and CD31. In addition, a higher SUVmax-P/M ratio was demonstrated in Her-2/neu positive subgroup than negative subgroup. At the same time, Gleason score and expression levels of these biomarkers showed no significant association with SUVmax.

Conclusions. Using the parameter SUVmax-P/M ratio, 11C-Choline PET/CT may be a valuable non-invasive imaging technology in the diagnosis of primary prostate cancer.

Open access

Ioannis D K Dimoliatis, Ioannis Zerdes, Athanasia Zampeta, Zoi Tziortzioti, Evangelos Briasoulis and Ioannis Souglakos

students and the teachers respectively, before and after the five-day full-time meeting. The responses were coded in the 0–100 scale: absolutely disagree 0; disagree 20; rather disagree 40; rather agree 60; agree 80; absolutely agree 100. Then, the question mean score (corresponding to one L2LO), the subscale mean score (corresponding to one L1LO), and the whole questionnaire mean score were calculated. All scores are given in the standard 0–100 scale , the easiest to grasp, interpret and remember without any need for further training (% is a universal scale). While

Open access

Pelin Güneri, Joel B. Epstein, Judith E. Raber-Durlacher, Hülya Çankaya, Hayal Boyacıoğlu and Andrei Barasch

Abstract

Aim: Dental treatment is necessary in oncology patients since pre-existing oro-dental disease may influence cancer treatment and prognosis. This study investigated the applicability of two indices in reflecting the actual oral health status of 100 non-cancer patients who were admitted for dental complaints/routine controls.

Methods: The radiographic examination results and the decayed, missed, filled teeth score represented the ‘actual oro-dental status’. The simplified oral hygiene index was utilised for oral hygiene determination, and general oral health assessment index was used to establish the self-perceived oral health.

Results: No correlation was observed between actual oro-dental status and the simplified oral hygiene index (p = 0.27), but the relationship between oro-dental status and general oral health assessment index was significant (p = 0.026). Items 9, 5 and 1 (How often were you concerned about problems with your teeth, gums or dentures? How often were you able to eat anything without feeling discomfort? How often did you limit the kinds or amounts of food you eat because of problems with your teeth or dentures?) presented correlation (r = −0.285, r = 0.268, and r = −0.248).

Conclusion: Three items of GOHAI (Geriatric Oral Health Assessment Index) may be used to identify the requisite of dental treatment in patients and to aid in immediate dental treatment planning.