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Loredana Mӑdӑlina Popa, Bogdan Timar, Amorin Remus Popa and Mircea Ioachim Popescu

, Simmons RK, Sharp SJ, Griffin SJ, Wareham NJ. Cardiovascular risk assessment scores for people with diabetes: a systematic review. Diabetologia 52: 2001-2014, 2009. 9. Pearson TA, Mensah GA, Alexander RW et al. Markers of inflammation and cardiovascular disease: application to clinical public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation 107: 499-511, 2003. 10. Sinderman AJ, Williams K, Contois JH et al. A metaanalysis of low

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Shahinul Alam, SKM Nazmul Hasan, Golam Mustafa, Mahabubul Alam, Mohammad Kamal and Nooruddin Ahmad

NASH. Only few studies and pilot trials of PTX[ 14 - 16 ] suggested that pentoxifylline reduced plasma TNF- α and IL-6, ALT and AST levels but there is scarcity of data to observe improvement of NAFLD activity score (NAS) and fibrosis score in patients with nonalcoholic steatohepatitis (NASH). The aim of this study was to observe the effect of pentoxifylline on histological activity and fibrosis of Bangladeshi nonalcoholic steatohepatitis patients. Materials and methods This study was conducted from August 2014 to December 2015 as an open label Randomized

Open access

Syed Mudassir Laeeq, Abbas Ali Tasneem, Farina M. Hanif, Nasir Hassan Luck, Rajesh Mandhwani and Rajesh Wadhva

dysfunction and increased risk of vascular malformation. [ 2 ] Since GI diseases are common in ESRD patients, multiple studies have been conducted to study the endoscopic findings in this population. Most common reason for endoscopic evaluation has been UGIB. [ 2 , 4 ] Several scoring systems have also been developed to classify patients with UGIB according to their outcome. One such scoring system is the Glasgow Blatchford bleeding Score (GBS), a well-established tool to stratify patients in dire need of intervention from UGIB on the basis of their history, physical

Open access

Jawaid Iqbal, Muhammad Ali Khalid, Farina M. Hanif, Rajesh Mandhwani, Syed Mudassir Laeeq, Zain Majid and Nasir Hassan Luck

Stage Liver Disease (MELD) is a validated chronic liver disease (CLD) severity scoring system that includes serum bilirubin, serum creatinine, and the international normalized ratio (INR). An increasing MELD score is associated with progression of hepatic dysfunction, severity and three-month mortality risk.[ 5 ] MELD is also used to prioritize patients on liver transplant waiting list. It is considered better than the Child-Turcotte-Pugh (CTP) score, in part, because of the inclusion of creatinine, which reflects the prognostic impact of renal function.[ 6

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Alin Albai, Mirela Frandeș, Ramona Luminița Sandu, Gabriel Spoială, Flavia Hristodorescu, Bogdan Timar and Romulus Timar

, Fitzgerald AP et al. Estimation of ten-year risk of fatal cardiovascular disease in Europe: the SCORE project. Eur Heart J 24: 987-1003, 2003. 6. D’Agostino RB Sr, Vasan RS, Pencina MJ et al. General cardiovascular risk profile for use in primary care: the Framingham Heart Study. Circulation 117: 743-753, 2008. 7. Centers for Disease Control and Prevention . National diabetes fact sheet: National estimates and general information on diabetes and prediabetes in the United States, 2011. Atlanta, GA: U.S. Department of Health and Human Services, Centers for

Open access

Vaia D. Raikou

coronary heart disease is the Framingham risk score (FRS). According to the National Institutes of Health, the patients having chronic kidney disease are considered as having a coronary heart disease risk equivalent, meaning that they are primarily patients with a 10-year risk for myocardial infarction or coronary death >20%, despite without known coronary heart disease. [ 8 ] Metabolic acidosis, a common condition and an important manifestation of the late stage of chronic kidney disease, leads to clinically significant consequences, including bone disease disorders

Open access

Herbert Djiambou-Nganjeu

, lethargy, impaired intellectual ability, and so on in end-stage coma (with or without response to stimuli) and later death in severe cases. [ 4 , 5 , 6 , 7 ] The neuropsychological peculiarity can be revealed by the use of psychometric tests, for instance, neuropsychological tests such as Halstead-Reitan (H-R) score and Child-Pugh score or other psychometric tests. [ 8 , 9 , 10 ] There is no gold standard test to diagnose HE due to the personal peculiarities of each case. That is why physicians mostly rely on their personal experiences, equipment availability, and

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Dimitrios Velissaris, Nikolaos-Dimitrios Pantzaris, Anastasia Skroumpelou, Panagiotis Polychronopoulos, Vasilios Karamouzos, Charalampos Pierrakos, Charalampos Gogos and Menelaos Karanikolas

Introduction Brain dysfunction is a frequent complication of sepsis even in cases of extra-cranial origin and is related to several underlying mechanisms. Encephalography (EEG) seems to be a useful tool in detecting the presence of encephalopathy in patients with sepsis. Although EEG is not a specific test, it is sensitive and can detect abnormalities even when clinical neurologic examination is normal. The aim of this study was to document the EEG abnormalities and search for correlations between EEG findings and commonly used severity and prognostic scores

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Ovidiu Mitu, Florin Mitu, Maria-Magdalena Leon, Mihai Roca, Andreea Gherasim and Mariana Graur

JW, Jang EH, Kim MK et al. Diabetic retinopathy is associated with subclinical atherosclerosis in newly diagnosed type 2 diabetes mellitus. Diabetes Res Clin Pract 91: 253-259, 2011. 5. Shah PK. Screening asymptomatic subjects for subclinical atherosclerosis: can we, does it matter, and should we? J Am Coll Cardiol 56: 98-105, 2010. 6. Lindström J, Tuomilehto J. The diabetes risk score: a practical tool to predict type 2 diabetes risk. Diabetes Care 26: 725-731, 2003. 7. Perk J, De Backer G, Gohlke H et al. European Guidelines on

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Mohammad Qasim Khan, Vijay Anand, Norbert Hessefort, Ammar Hassan, Alya Ahsan, Amnon Sonnenberg and Claus J. Fimmel

, dedicated patient visits, and is therefore not easily applicable to large patient populations. In recent years, a number of serum-based fibrosis tests have been developed and validated. Many studies have reported reasonable performance characteristics and good agreement with biopsy or elastography data.[ 4 , 5 ] With the advent of electronic medical record systems, fibrosis scores can be easily calculated after extracting the pertinent test results for each patient. This process does not require additional patient visits, and can be applied to large patient cohorts. As