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Effect of pentoxifylline on histological activity and fibrosis of nonalcoholic steatohepatitis patients: A one year randomized control trial

NASH. Only few studies and pilot trials of PTX[ 14 - 16 ] suggested that pentoxifylline reduced plasma TNF- α and IL-6, ALT and AST levels but there is scarcity of data to observe improvement of NAFLD activity score (NAS) and fibrosis score in patients with nonalcoholic steatohepatitis (NASH). The aim of this study was to observe the effect of pentoxifylline on histological activity and fibrosis of Bangladeshi nonalcoholic steatohepatitis patients. Materials and methods This study was conducted from August 2014 to December 2015 as an open label Randomized

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Correlation of Residual Diuresis with MIS Score and Nutritional Status in Peritoneal Dialysis Patients: A Croatian Nationwide Study


Introduction. Residual diuresis (RD) is an important predictor of mortality and cardiovascular (CV) deaths in peritoneal dialysis (PD) patients, and contributes more to overall survival compared to PD clearance. In this study we investigated the correlation between RD and CV outcomes in PD patients.

Methods. A total of 190 PD patients from 13 dialysis centers, a national representation, were included in this analysis. Biomarkers of anemia, nutritional status [malnutrition inflammation score (MIS), subjective global assessment (SGA), serum albumin, anthropometric measurements including body mass index (BMI)], dialysis dose (Kt/V) and laboratory measurements were determined. RD was estimated using the volume of daily urine.

Results. There were 78(41.05 %) females and 112 (58.95 %) males; aged 57.35±14.41 years, on PD for 24.96±24.43 months. Fifty-six patients had diabetes type II (44 as primary kidney disease). The mean RD was 1170±673.6 ml (range 0-3000 mL). Statistically significant correlations between RD and BMI, hip circumference, time on PD, Kt/V, MIS, SGA, erythrocytes (E), Hemoglobin (Hb), PTH, and serum albumin were observed.

Conclusions. We demonstrated a significant correlation between RD and MIS score, SGA, anthropometry and albumin. Every effort should be invested to maintain RD for as long as possible to achieve optimal treatment results and to decrease CV mortality in PD population.

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Upper gastrointestinal bleeding in patients with end stage renal disease: causes, characteristics and factors associated with need for endoscopic therapeutic intervention

dysfunction and increased risk of vascular malformation. [ 2 ] Since GI diseases are common in ESRD patients, multiple studies have been conducted to study the endoscopic findings in this population. Most common reason for endoscopic evaluation has been UGIB. [ 2 , 4 ] Several scoring systems have also been developed to classify patients with UGIB according to their outcome. One such scoring system is the Glasgow Blatchford bleeding Score (GBS), a well-established tool to stratify patients in dire need of intervention from UGIB on the basis of their history, physical

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Correlation between MELD and UNa/K ratio in predicting renal dysfunction in cirrhotic patients

Stage Liver Disease (MELD) is a validated chronic liver disease (CLD) severity scoring system that includes serum bilirubin, serum creatinine, and the international normalized ratio (INR). An increasing MELD score is associated with progression of hepatic dysfunction, severity and three-month mortality risk.[ 5 ] MELD is also used to prioritize patients on liver transplant waiting list. It is considered better than the Child-Turcotte-Pugh (CTP) score, in part, because of the inclusion of creatinine, which reflects the prognostic impact of renal function.[ 6

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Metabolic acidosis status and mortality in patients on the end stage of renal disease

coronary heart disease is the Framingham risk score (FRS). According to the National Institutes of Health, the patients having chronic kidney disease are considered as having a coronary heart disease risk equivalent, meaning that they are primarily patients with a 10-year risk for myocardial infarction or coronary death >20%, despite without known coronary heart disease. [ 8 ] Metabolic acidosis, a common condition and an important manifestation of the late stage of chronic kidney disease, leads to clinically significant consequences, including bone disease disorders

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Hepatic encephalopathy in patients in Lviv (Ukraine)

, lethargy, impaired intellectual ability, and so on in end-stage coma (with or without response to stimuli) and later death in severe cases. [ 4 , 5 , 6 , 7 ] The neuropsychological peculiarity can be revealed by the use of psychometric tests, for instance, neuropsychological tests such as Halstead-Reitan (H-R) score and Child-Pugh score or other psychometric tests. [ 8 , 9 , 10 ] There is no gold standard test to diagnose HE due to the personal peculiarities of each case. That is why physicians mostly rely on their personal experiences, equipment availability, and

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Electroencephalographic abnormalities in sepsis patients in correlation to the calculated prognostic scores: A case series

Introduction Brain dysfunction is a frequent complication of sepsis even in cases of extra-cranial origin and is related to several underlying mechanisms. Encephalography (EEG) seems to be a useful tool in detecting the presence of encephalopathy in patients with sepsis. Although EEG is not a specific test, it is sensitive and can detect abnormalities even when clinical neurologic examination is normal. The aim of this study was to document the EEG abnormalities and search for correlations between EEG findings and commonly used severity and prognostic scores

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Utility of electronic medical recordbased fibrosis scores in predicting advanced cirrhosis in patients with hepatitic C virus infection

, dedicated patient visits, and is therefore not easily applicable to large patient populations. In recent years, a number of serum-based fibrosis tests have been developed and validated. Many studies have reported reasonable performance characteristics and good agreement with biopsy or elastography data.[ 4 , 5 ] With the advent of electronic medical record systems, fibrosis scores can be easily calculated after extracting the pertinent test results for each patient. This process does not require additional patient visits, and can be applied to large patient cohorts. As

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Hepatic encephalopathy in liver cirrhosis

Introduction Liver cir rhosis (LC) is a common gastroenterological pathology among adults. Its aetiological factors are: alcohol abuse, hepatitis B infection, hepatitis C infection, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis and others.[ 1 , 2 ] Cirrhosis with multiple-aetiologies are more susceptible of developing multiple organ failures, predominantly kidney, brain, heart and others.[ 1 , 3 ] This disease can be classified using several methods and these cases will be focusing on Halstead-Reitan and Child-Pugh score classification

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Effect of weight reduction on histological activity and fibrosis of lean nonalcoholic steatohepatitis patient

progression to cirrhosis or hepatocellular carcinoma (HCC). At present, the resolution of the histological findings of NASH is now approved as a surrogate endpoint. The major treatment offered for NAFLD remains lifestyle changes including weight reduction by a healthy diet and performing regular physical activity. [ 12 , 13 ] It is evident that improvements of liver histology in NASH can be achieved through losing a certain amount of weight. [ 14 ] Promrat et al . in his RCT showed that almost 7–10% of weight reduction can improve the NAFLD activity score (NAS) and its

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