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Eduard Adamescu, Cătălina Niculescu and Carmen Dobjanschi
Background and Aims: “Prediabetes” is defined by Impaired Fasting Glucose (IFG) or Impaired Glucose Tolerance (IGT), both states associated with increased risk for diabetes and high cardiovascular (CV) risk. The aim of our study was to investigate a population with prediabetes compared to a group from the general population in respect with the risk for progression to diabetes and CV risk parameters. Materials and Methods: We investigated 124 ambulatory patients with prediabetes and 98 persons without any known metabolic disorders (control group), for CV risk parameters and risk of developing diabetes. Results: We found statistically significant differences (p <0.05) for average weight, waist, BMI and lipids between the two groups. We also found a double risk score of developing diabetes in prediabetes patients compared to the control group. No significant differences were found in terms of anthropometric parameters, lipid values, cardiovascular disease and diabetes risk score for the IFG, IGT and IFG + IGT subgroups. Conclusions: People with prediabetes have features that differentiate them from the general population, both in terms of the history, anthropometric and biochemical characteristics. Increased risk for progression to diabetes, but also highly increased CV risk makes very useful the prevention efforts focused on this population group.
Rucsandra Dănciulescu Miulescu, Denisa Margină, Anca Ungurianu, Roxana Irina Roșca, Alina Nicolau and Andrada Doina Mihai
Background and Aims. Previous studies report the presence of cognitive impairment in patients with overt hypothyroidism. The thyroid hormones are essential for neurological and intellectual functions. Type 2 diabetes mellitus (T2DM) subjects are exposed to higher risk of cognitive function alteration compared to nondiabetic subjects. The aim of the present study was to analyze the cognitive function of T2DM subjects with overt hypothyroidism.
Materials and Methods. We performed an observational study between 2015-2017. A total of 12 patients (11 women and 1 men) with overt hypothyroidism and T2DM were recruited for this study. Their cognitive function was compared with that of subjects of a control group (16 patients - 12 women and 4 men with T2DM but without overt hypothyroidism). Cognitive function was evaluated using the Mini Mental State Examination (MMSE) test. Serum thyroid stimulating hormone (TSH) levels were measured by immunoradiometric assay, free thyroxine (FT4) by radioimmunoassay while fasting plasma glucose (FPG) levels were evaluated using automated devices.
Results. There were no significant differences between the two groups in respect of age and FPG. In the study group, mean TSH and FT4 levels were 11.76±4.43 mIU/L, resepectively 0.53±0.08 ng/dL while in the control group these were 2.60±0.40 mIU/L, respectively 1.12±0.19 ng/dL (p<0.001). Moderate cognitive impairment was present in 3 patients of the study group (25.00%) and in 2 subjects from the control group (12.50%). Mild cognitive impairment was present in 4 patients (33.33%) of the study group and in 2 subjects from the control group (12.50%).
Conclusion. This study showed that MMSE scores are significantly reduced in subjects with T2DM and hypothyroidism compared to subjects with T2DM without hypothyroidism (p<0.004). The study revealed a negative correlation between TSH and MMSE score in the study group.
Deniz Korkut, Gul Ergor, Gulsah Kaner and Nilgun Seremet Kurklu
Background and Aims: Diabetes is increasing rapidly in Turkey as most countries in the world. The prevention of complications which is the main aim in the treatment of diabetes can be accomplished partly with nutrition education. The aim of this study was to assess the relationship between nutrition knowledge (NK) and complications in patients with type 2 diabetes. Materials and Methods: 280 patients with 8-20 years of diabetes duration who applied to diet outpatient clinic were recruited. The questionnaire was prepared by the investigators to assess the NK. A score was calculated on the scale of 100. The complications were determined based on hospital records and patients’ selfreport. Results: 63.2% of participants were female and 36.8% were male. The most common complications in participants were retinopathy (56.1%) and neuropathy (42.9%). The mean NK score was 80.2±11.7. At least one complication was seen in 85.0% of the participants. There was no significant difference for having any complication in patients with adequate and inadequate NK. However the risk of diabetic foot, and coronary artery disease was significantly higher in women with inadequate NK. Conclusion: NK is quite high in long term diabetic patients. However no effect of the NK on the development of complications could be shown. The difference of effect between men and women could be due to the fact that food is mostly prepared by women thus not much chance of the knowledge of men to be reflected on his eating habits. The knowledge difference among female patients was seen in the results as; in women with inadequate NK, the prevalence of diabetic foot and CAD was significantly higher.