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Effect of pentoxifylline on histological activity and fibrosis of nonalcoholic steatohepatitis patients: A one year randomized control trial

therapeutic interventions to control concomitant disease, for example, hyperlipidemia, hypertension and type 2 DM. Pentoxifylline (PTX) is known to decrease oxidative stress.[ 10 ] PTX also has hydroxyl and peroxyl radical scavenging effects[ 11 ] and specifically inhibits lipid peroxidation.[ 12 ] Moreover, pentoxifylline has anti-inflammatory properties and it is also known to definitely suppress TNF- α gene transcription, preventing TNF- α synthesis.[ 13 ] Therefore, PTX plays an important role in the inhibition of second hit hypothesis required for pathogenesis of

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Trends in vascular pharmacology research in the Department of Pharmacology and Clinical Pharmacology, Faculty of Medicine, Comenius University, Bratislava

, Djibril MN, Fačkovcová D, Kriška M, Kurtanský A. (2002). Comparison of vasoconstrictor responses to selected NSAIDs in rabbit renal and femoral arteries. Bratisl Lek Listy   103 : 50-53. Kristová V, Kiss A, Pirnik Z, Kriška M, Ježová D. (2006). Effect of pentoxifylline on endothelaemia and hypothalamic-pituitary-adrenocortical axis activation in female rats under stress exposure. Gen Physiol Biophys   25 : 81-89. Kristová V, Kriška M, Babál P, Djibril MN, Slámová J, Kurtanský A. (2000). Evaluation of endothelium

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Markers of Atherosclerosis in Hypertensive Patients with Less Advanced Chronic Kidney Disease

pentoxifylline administration. Am J Nephrol. 2006;26(6):562–70. 4. Fogo AB. Mechanisms of progression of chronic kidney disease. Pediatr Nephrol. 2007;22(12):2011–22. 5. Snaedal S, Heimbürger O, Qureshi AR, et al. Comorbidity and acute clinical events as determinants of C-reactive protein variation in hemodialysis patients: implications for patient survival. Am J Kidney Dis. 2009;53(6):1024-33. 6. Turkmen K, Guney I, Yerlikaya FH, Tonbul HZ. The relationship between neutrophil-to-lymphocyte ratio and inflammation in end-stage renal disease patients. Ren Fail

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A model of experimental acute hematogenous pyelonephritis in the rat

References 1. Yagmurlu A, Boleken ME, Ertoy D, et al. Preventive effect of pentoxifylline on renal scarring in rat model of pyelonephritis. Urology 2003;61(5):1037-41. 2. Li ML, Liang B, Tang JW, et. al. Pharmacodynamic study of Relinqing granules on bacterial pyelonephritis model in rats. Zhongguo Zhongyao Zazhi 2006;31(2):153-5. 3. Emamghorashi F, Owji SM, Kohanteb J, et al. Every other day gentamicin injection in experimental pyelonephritis in rats: risk of scar formation. Iran J Med Sci 2007

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Morpho-Pathological Review on the Healing of Synthetic Vascular Grafts

by different graft materials In Vitro are affected by pentoxifylline and iloprost. J Biomed Master Res. 1997;36:400. 7. Raiter A, Bechor Z, Kleiman M, et al. Angiogenic peptides improve blood flow and promote capillary growth in a diabetic and ischaemic mouse model. Eur J Vasc Endovasc Surg. 2010;40(3):381-388. 8. Alobaid N, Salacinski HJ, Sales KM, et al. Nanocomposites containing bioactive peptides promote endothelialisation by circulating progenitor cells: An In Vitro evaluation. Eur J Vasc Endovasc Surg. 2006

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A Triad of Exophtalmos, Pretibial Myxedema and Acropachy in a Patient With Graves’ Disease / Egzoftalmus, pretibijalni miksedem i akropatija − trijada prisutna kod obolelog od Grejsove bolesti

Reconstr Surg l999;15(4):260-71. 23. Weetman AP. Graves’ disease. N Engl J Med 2000;26:1236-48. 24. Pineda AMM, Tianco EAV, Tan JB, Casintahan FA, Beloso MB. Oral pentoxifylline and topical clobetasol propionate ointment in the treatment of pretibial myxedema, with concomitant improvement of Graves’ ophthalmopathy. J Eur Acad Dermatol Venereol 2007;21:1441-2. 25. Susser WS, Heermans AG, Chapman MS, Baughman RD. Elephantiasic pretibial myxedema: A novel treatment for an uncommon disorder. J Am Acad Dermatol 2002

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Biochemical Changes in Experimental Rat Model of Abdominal Compartment Syndrome

;43(5):852-5. 10. Eğin S, Açıksarı K, Ercan G, et al. Effects of pentoxifylline on oxidative stress in rats with abdominal compartment syndrome model. Int J Surg Open 2016;5:5-10. 11. Bloomfield GL, Ridings PC, Blocher CR, et al. A proposed relationship between increased intraabdominal, intrathoracic, and intracranial pressure. Crit Care Med 1997;25(3):496-503. 12. Kovacheva N, Ardasheva RG, Marchev V, et al. Experimental model of abdominal compartment syndrome. International Turkish Medical Student Congress (IMESCON), 6-8 May 2011, Samsun

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Demographic and Comorbidity Pattern of Patients with Critical Limb Ischemia

critical limb ischemia? J Vasc Surg 2003;37:704-8. 24. Norwegian Pentoxifyllin Multicenter Trial Group. Efficacy and clinical tolerance of parenteral pentoxifylline. Int Angiol 1996;15:75-80. 25. Brock FE, Abri O, Baitsch G, et al. [Iloprost in the treatment of ischemic tissue lesions in diabetics. Results of a placebo-controlled multicenter study with a stable prostacyclin derivative.] Schweiz Med Wochenschr 1990;120:1477-82 [German]. 26. Brass EP, Anthony R, Dormandy J, et al. Parenteral therapy with lipo-ecraprost, a

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Beneficial Effect of Chronic Treatment with Extracts from Rhodiola Rosea L. and Curcuma Longa L. on the Immunoreactivity of Animals Subjected to a Chronic Mild Stress Model

chronic mild stress protocol introduces a combined model of depression in rats: Reversibility by imipramine and pentoxifylline. Pharmacol Biochem Behav 2014;126:152-62. 13. Konsman JP, Veeneman J, Combe C, et al. Central nervous action of interleukin-1 mediates activation of limbic structures and behavioural depression in response to peripheral administration of bacterial lipopolysaccharide. Eur J Neurosci 2008;28(12):2499-510. 14. Mattioli L, Funari C, Perfumi M. Effects of Rhodiola rosea L. extract on behavioural and physiological

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Effect of weight reduction on histological activity and fibrosis of lean nonalcoholic steatohepatitis patient

management of NASH. [ 22 ] Among different drugs tested, [ 23 ] vitamin E, [ 24 , 25 ] pioglitazone, [ 25 ] liraglutide, [ 26 ] telmisartan, [ 27 ] pentoxifylline [ 28 ] were found to improve histological activity and fibrosis in different degrees. But these must be balanced with their potential adverse effects. Therefore, diet and lifestyle modification, with weight reduction remains the mainstay of treatment in these patients. [ 16 , 22 ] Previous studies testing the effectiveness of lifestyle modification in NAFLD have found that 7 to 10% weight loss is

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