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Damian Borys, Katarzyna Szczucka-Borys and Kamil Gorczewski

References Autret, D., Bitar, A., Ferrer, L., Lisbona, A. and Bardies, M. (2005). Monte Carlo modeling of gamma cameras for I-131 imaging in targeted radiotherapy, Cancer Biotherapy and Radiopharmaceuticals   20 (1): 77-84. Borys, D., Panek, R., Gorczewski, K., d'Amico, A., Steinhof, K. and Psiuk-Maksymowicz, K. (2006). Evaluation of SPECT-CT image fusion quality control, Biocybernetics and Biomedical Engineering   26 (4): 79-90. Bruyant, P. P. (2002). Analytic and iterative

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Baiba Līcīte, Arvīds Irmejs, Jeļena Maksimenko, Pēteris Loža, Genādijs Trofimovičs, Edvīns Miklaševičs, Jurijs Nazarovs, Māra Romanovska, Justīne Deičmane, Gunta Purkalne and Jānis Gardovskis

the contemporary management of patients with breast cancer. Surgery , 154 (4), 831–840. Johnson, J., Barmparas, G., Chung, A., Giuliano, A., Amersi, F. (2016). Predictors of complete response to neoadjuvant chemotherapy in breast cancer. Ann. Surg. Oncol. , 23 (3), 378–379. Koolen, B. B., Donker, M., Straver, M. E., van der Noordaa, M. E. M., Rutgers, E. J. T., Valdés Olmos, R. A., Vrancken Peeters, M. J. T. F. D. (2017). Combined PET-CT and axillary lymph node marking with radioactive iodine seeds (MARI procedure) for tailored axillary treatment

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Víctor M. Pérez-García, Susan Fitzpatrick, Luis A. Pérez-Romasanta, Milica Pesic, Philippe Schucht, Estanislao Arana and Pilar Sánchez-Gómez

interesting concept for the future, intratumor heterogeneity cannot be still fully sampled with most updated biopsies, even with genomic analysis [ 52 ] and in any case this would still provide static snapshots that may not describe real dynamics. Non-invasive imaging (mainly CT, MRI and PET) fulfill this gap with temporal resolution. However, spatial resolution in clinical imaging is approximately 1 mm, that may be enough for studying certain aspects of tumoral heterogeneity [ 53 ]. For the applied mathematician images are numbers and contain a great deal of