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Salih Macin, Meral Akarca, Burcin Sener and Yakut Akyon

early Pseudomonas aeruginosa infection. J Cyst Fibros. 2005 Aug;4(2):49-54. DOI: 10.1016/j.jcf.2005.05.018 12. Islan GA, Tornello PC, Abraham GA, Duran N, Castro GR. Smart lipid nanoparticles containing levofloxacin and DNase for lung delivery. Design and characterization. Colloids Surf B Biointerfaces. 2016 Jul;143(1):168-76. DOI: 10.1016/j.colsurfb.2016.03.040 13. Çıragil P, Söyletir G. Alginate, elastase and alkaline protease product,on of Pseudomonas aeruginosa strains isolated from various body sites. Mikrobiyol Bul. 2004 Oct;38

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Ana Irina Mereuţă, Aida Corina Bădescu, Olivia Simona Dorneanu, Luminiţa Smaranda Iancu and Cristina Gabriela Tuchiluş

References 1. Gupta V. Metallo beta lactamases in Pseudomonas aeruginosa and Acinetobacter species. Expert Opin Investig Drugs. 2008 Feb; 17(2):131-43. 2. Walsh TR, Toleman MA, Poirel L, Nordmann P. Metallo- β-lactamases: the quiet before the storm? Clin Microbiol Rev. 2005 Apr; 18:306-325. 3. Walsh F, Amyes SG. Carbapenem resistance in clinical isolates of Pseudomonas aeruginosa . J Chemother. 2007 Aug; 19:376-381. 4. Cornaglia G, Giamarellou H, Rossolini GM. Metallo- β

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Yi-hai Gu, Xiao Zhu, Jing-yun Li, Jun Zhang, Qing-yuan Zhou, Yue Ma, Chang-qin Hu, Shao-hong Jin and Sheng-hui Cui

References 1. Strateva T, Yordanov D. Pseudomonas aeruginosa - a phenomenon of bacterial resistance. J Med Microbiol 2009;58:1133-1148. 2. McGowan JE Jr. Resistance in nonfermenting gram-negative bacteria: multidrug resistance to the maximum. Am J Infect Control 2006;34:s29-s37; discussion s64-s73. 3. Mesaros N, Nordmann P, Plesiat P, Roussel-Delvallez M, Van Eldere J, Glupczynski Y, et al. Pseudomonas aeruginosa: resistance and therapeutic options at the turn of the new millennium. Clin Microbiol Infect 2007

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Luminița Matroș, Tibor Ludovic Krausz, Stanca Lucia Pandrea, Monica Ioana Ciontea, Erica Chiorean, Lia Sorina Pepelea, Antonela Marcela Berar and Lia Monica Junie

.1093/jac/dki130. 6. Marsik FJ, Nambiar S. Review of Carbapenemases and AmpC-beta lactamases. Pediatr Infect Dis J. 2011;30(12):1094-5. DOI: 10.1097/ INF.0b013e31823c0e47. 7. Meletis G, Exindari M, Vavatsi N, Sofianou D, Diza E. Mechanisms responsible for the emergence of carbapenem resistance in Pseudomonas aeruginosa. Hippokratia. 2012 Oct;16(4):303-7. 8. Cuzon G, Naas T, Villegas M-V, Correa A, Quinn JP, Nordmann P. Wide dissemination of Pseudomonas aeruginosa producing beta-lactamase blaKPC-2 gene in Colombia. Antimicrob

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Bianca-Simona Trușcă, Irina Gheorghe, Luminita Marutescu, Carmen Curutiu, Florica Marinescu, Camelia Mihaela Ghiță, Elvira Borcan, Liliana Țuică, Vali Minciuna, Hilda-Edit Gherghin, Mariana Carmen Chifiriuc and Veronica Lazar

;3(1):48-54. 8. Naas T, Philippon L, Poirel L, Ronco E, Nordmann P. An SHV-derived extended spectrum β-lactamase in Pseudomonas aeruginosa. Antimicrob Agents Chemother. 1999;43:1281-4. 9. Israil A, Chifiriuc C, Palade G, Cotar A. Clinical and bacteriological aspects of bacterial infections associated to abdominal surgical emergencies. Ars Docenti Publ. House. 2013:150. 10. Poirel L, Walsh TR, Cuvillier V, Nordmann P. Multiplex PCR for detection of acquired carbapenemase genes. Diagn Microbiol Infect Dis. 2011;70(1):119-23. DOI: 10.1016/j

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Wei Guo, Jie Zhang, Jing-yun Li, Yue Ma and Sheng-hui Cui

References 1 A, Díaz E, et al. Patterns of colonization by Pseudomonas aeruginosa in intubated patients: a 3-year prospective study of 1,607 isolates using pulsed-field gel electrophoresis with implications for prevention of ventilator-associated pneumonia. Intensive Care Med 2004;30:1768-1775, 2 American Thoracic Society; Infectious Diseases Society of America. Guidelines for the management of adults with hospitalacquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med 2005

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Adrian Man, Andrei Şerban Gâz, Anca Delia Mare and Lavinia Berţa

References 1. Kampf G, Löffler H, Gastmeier P. Hand Hygiene for the Prevention of Nosocomial Infections. Dtsch Ärztebl Int. 2009 Oct;106(40):649-55. 2. Mathur P. Hand hygiene: Back to the basics of infection control. Indian J Med Res. 2011 Nov;134(5):611-20. DOI: 10.4103/0971-5916.90985 3. AFE14 - 148to158.pdf [Internet]. Available from: http:// www.who.int/water_sanitation_health/medicalwaste/ 148to158.pdf 4. Tutelcă

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Agnieszka Noszczyk-Nowak, Marcin Nowak, Urszula Pasławska and Józef Nicpoń

References 1. Danner R.L., Natanson C., Hosseini J.M., Banks S., MacVittie T.J., Parrillo J.E.: Pseudomonas aeruginosa compared with Escherichia coli produces less endotoxaemia but more cardiovascular dysfunction and mortality in canine model of septic shock. Chest 1990, 98 , 1480-1487. 2. Hagman R., Lagerstedt A.-S., Fransson B.A., Bergstrom A., Haggstrom J.: Cardiac troponin I level in canine pyometra. Acta Vet Scand 2007, 49 , 6-14. 3. Hagman R., Kindahl H., Lagerstedt A.-S.: Pyometra in bitches

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Yuchi Jia

-N-acetylglucosamine transferase (MurA) and inhibit MurA activity irreversibly, thus blocking the first step of bacterial cytoderm synthesis effectively and then destroying the bacteria [ 2 ]. Fosfomycin is a rapid bactericide for the bacterial breeding season; it has excellent antibacterial activity against Gram-positive bacteria (such as Staphylococcus aureus and Enterococcus ) and Gram-negative bacteria (such as Enterobacteriaceae , Haemophilus , Pseudomonas aeruginosa , and so on). In addition, fosfomycin also has good antibacterial effects on methicillin-resistant Staphylococcus

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Chang-Liang He, Qiong Yi, Yuan-Fang Li, Hang Yang and Lu Wang

References 1. Akira S., Takeda K.: Toll-like receptor signalling. Nat Rev Immunol 2004, 4 , 499-511. 2. Akira S., Takeda K., Kaisho T.: Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol 2001, 2 , 675-680. 3. Bannerman D.D., Chockalingam A., Paape M.J., Hope J.C.: The bovine innate immune response during experimentally-induced Pseudomonas aeruginosa mastitis. Vet Immunol Immunopathol 2005, 107 , 201-215. 4. Beutler B., Hoebe K., Du X., Ulevitch R