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Yasemin Ustundag, lknur Aykurt Karlıbel, Murat Sambel, Murat Ozturk, Atilla Satır, Elif Yolgosteren, Salim Neselioglu and Ozcan Erel

malondialdehyde levels in women with overactive bladder. Investig Clin Urol 2018; 59: 252-6. 10. Üstünda Y, Demirci H, Balık R, Erel O, Özaydın F, Kücük B, et al. Thiol/disulfide homeostasis in pregnant women with obstructive sleep apnea syndrome. J Matern Fetal Neonatal Med 2017; 27: 1-6. 11. Polat M, Ozcan O, Sahan L, Üstündag-Budak Y, Alisik M, Yilmaz N, et al. Changes in thiol-disulfide homeostasis of the body to surgical trauma in laparoscopic cholecystectomy patients. J Laparoendosc Adv Surg Tech A 2016; 26(12): 992-6. 12

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Xiao-yan Zhang, Lin Wang, Yuhuan Qiao and Ruixia Guo

Expressions of sFRP1 and β-Catenin in Cervical Cancer

This study aimed to investigate the expressions of secreted frizzled-related protein 1 (sFRP1) and β-catenin in cervical cancer and cervical intraepithelial neoplasia (CIN), and to explore the relationship between both proteins and the prognosis of cervical cancer. Immunohistochemistry was performed to detect the protein expressions of sFRP1 and β-catenin in cervical cancer (n=78), CIN (n=30) and normal cervical tissues (n=20), and the relationships of sFRP1 and β-catenin with the clinicopathological characteristics and prognosis of cervical cancer were analyzed. The positive rate of sFRP1 was 100%, 70% and 33.3% in the normal cervical tissues, CIN and cervical cancer, respectively (P<0.05). The sFRP1 expression was positively correlated with the stage of cervical cancer and lymphatic metastasis (P<0.05). The 5-year survival rate was significantly higher in patients positive for sFRP1 than in those negative for sFRP1 (P<0.05). The rate of abnormal β-catenin expression in the normal cervical tissues, CIN and cervical cancer was 5%, 43.3% and 70.5%, respectively (P<0.05). The abnormal β-catenin expression was positively correlated with the stage of cervical cancer, lymphatic metastasis and pathological grade (P<0.05). The 5-year survival rate was markedly higher in patients with normal β-catenin expression than in those with abnormal β-catenin expression (P<0.05). The sFRP1 expression was negatively related to the β-catenin expression in cervical cancer (r = -0.557, P<0.001). Both sFRP1 and β-catenin play important roles in the initiation and development of cervical cancer, and both proteins can be used as indicators predicting the prognosis of cervical cancer.

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Zoran Mijušković, Ljiljana Rackov, Janko Pejović, Sandra Živanović, Jelica Stojanović and Zoran Kovačević

-6. Girbal-Neuhauser E, Durieux J, Arnaud M, et al. The epitopes targeted by the rheumatoid arthritis-associated antifilaggrin autoantibodies are post-translationally generated on various sites of (pro)filaggrin by deimination of arginine residues. J Immunol 1999; 162: 585-94. Menard H, Boire G, Lopez-Longo F, Lapointe S, Larose A. Insights into rheumatoid arthritis derived from the Sa immune system. Arthritis Res 2000; 2: 429-32. Vossenaar ER, Despres N, Lapointe E, Van der Heijden A, Lora M, Senshu T, Van Verooij WJ

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Sol Green

References Plebani M, Carraro P. Mistakes in a stat laboratory: Types and frequency. Clin Chem 1997; 43: 1348-51. Dale JC, Novis DA. Outpatient phlebotomy success and reasons for specimen rejection: A Q-Probes study. Arch Pathol Lab Med 2002; 126: 416-9. Data submitted for publication by Dr. Tester Ashavid. Lippi G, Guidi GC. Risk management in the preanalytic phase of laboratory testing. Clin Chem Lab Med 2007; 45: 720

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Mustafa Kaplan, Ihsan Ates, Mahmut Yüksel, Yasemin Ozderin Ozin, Muhammed Yener Akpinar, Canan Topcuoglu and Ertuğrul Kayaçetin

, Weissen-Plenz G, Schmitz M, Wieser H, et al. Endocytotic segregation of gliadin peptide 31-49 in enterocytes. Gut 2010; 59: 300–10. 12. Stojiljkovic V, Todorovic A, Radlovic N, Pejic S, Mladenovic M, Kasapovic J, et al. Antioxidant enzymes, glutathione and lipid peroxidation in peripheral blood of children affected by coeliac disease. Ann Clin Biochem 2007; 44: 537–43. 13. Odetti P, Valentini S, Aragno I, Garibaldi S, Pronzato MA, Rolandi E, et al. Oxidative stress in subjects affected by celiac disease. Free Radic Res 1998; 29: 17–24. 14. Szaflarska

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Olga A. Baturina, Alexey E. Tupikin, Tatyana V. Lukjanova, Svetlana V. Sosnitskaya and Igor V. Morozov

References 1. Guldberg P, Rey F, Zschocke J, Romano V, Francois B, Michiels L, et al. A European multicenter study of phenyl-alanine hydroxylase deficiency: classification of 105 mutations and a general system for genotype-based prediction of metabolic phenotype. Am J Hum Genet 1998; 63: 71–9. 2. Blau N, van Spronsen FJ, Levy HL. Phenylketonuria. Lancet 2010; 376: 1417–27. 3. DiLella AG, Kwok SC, Ledley FD, Marvit J, Woo SL. Molecular structure and polymorphic map of the human phenylalanine hydroxylase gene. Biochemistry 1986; 25: 743–9. 4. Lee YW

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Jelena Ćulafić, Jovanka Kolarović, Lato Pezo, Velibor Čabarkapa, Stanislava Nikolić, Aleksandra Stojadinović and Marija Bodroža Solarov

N. Iron deficiency. Pediatrics and Child Health 2011; 21(8): 339–43. 5. Peirano PD, Algarin CR, Chamorro RA, Reyes SC, Duran SA, Garrido MI et al. Sleep alterations and iron deficiency anemia in infancy. Sleep Med 2010; 11: 637–42. 6. Stoffman N, Brugnara C, Woods ER. An algorithm using reticulocyte hemoglobin content (CHr) measurement in screening adolescents for iron deficiency. J Adolescent Health 2005; 36: 529.1–6. 7. Kolarović J, Ćulafić J, Čabarkapa V, Vučković N, Vučković D, Bodroža-Solarov M. The incidence of anemia in the adult working

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Ivana Novaković, Nela Maksimović, Aleksandra Pavlović, Milena Žarković, Branislav Rovčanin, Duško Mirković, Tatjana Pekmezović and Dragana Cvetković

References 1. Khoury M, McCabe L, McCabe E. Population screening in the age of genomic medicine. N Engl J Med 2003; 348: 50-8. 2. Burke W. Genetic testing. N Engl J Med 2003; 347: 1867-75. 3. Novaković I, Maksimović N, Cvetković S, Cvetković D. Gene polymorphisms as markers of disease susceptibility. J Med Biochem 2010; 29(3): 1-5. 4. Todorović Z, Džoljić E, Novaković I, Mirković D, Stojanović R, Nešić Z, Krajinović M, Prostran M, Kostić V. Homocysteine serum levels and MTHFR C677T

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Velibor Čabarkapa, Mirjana Đerić and Zoran Stošić

References Lalić N, Ilić M. Klinički značaj analize urina: atlas sedimenta urina. Beograd: Društvo medicinskih biohemičara Srbije i Crne Gore, 2005: 5 pp. Kouri TT, Gant VA, Fogazzi GB. Towards European urinanalysis guidelines: introduction of a project under European Confederation of Laboratory Medicine. Clin Chim Acta 2000; 297: 305-11. Diendoerfer FH, Gangwer JR, Laird CW, Ringold RR. The &Gt;Yellow IRIS&Lt; urinalysis workstation: the first commercial application of &Gt

Open access

Vera Lukić

and responsibilities of laboratory medicine specialists in the verification of metrological traceability of in vitro medical diagnostics. J Med Biochem 2015; 34: 282–7. 5. Simundic AM. Nikolac N, Ivankovic V, Ferenec-Ruzic D, Kvaternik M, Topic E. Comparison of visual vs. automated detection of lipemic, icteric and hemolyzed specimens: can we rely on a human eye? Clin Chem Lab Med 2009; 47(11): 1361–5. 6. Dolci A, Panteghini M. Harmonization of automated hemolysis index assessment and use: Is it possible? Clin Chim Acta 432 (2014) 38–43. 7. Plebani