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Ana Testen, Miha Plevnik, Bogdan Štefane and Irena Kralj Cigić

. Ramakrishna and V. Srinivasarao, Method development and validation by GC-MS for quantification of 1-chloroethyl cyclohexyl carbonate as a genotoxic impurity in candesartan cilexetil drug substance, Int. J. Pharm. Pharm. Sci. 6 (2014) 370–372. 10. D. Henschler, Toxicity of chlorinated organic compounds: effects of the introduction of chlorine in organic molecules, Angew. Chem. Int. Ed. 33 (1994) 1920–1935; https://doi.org/10.1002/anie.199419201 11. J.-P. Senet, G. Sennyey and G. P. Wooden, A convenient new route to 1-haloalkyl carbonates, Synthesis 5

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Mohammed Abonassif, Mohammed Hefnawy, Mohamed Kassem and Gamal Mostafa

References H. Sugimoto, Y. Tsuchiya, H. Sungmi, K. Higurahi, N. Karibe, Y. Iimur, A. Sasaki, Y. Kawakami, T. Nakamura, S. Araki, Y. Yamanishi and K. Yamatssu, Novel piperidine derivatives. Synthesis and anti-acetylcholinesterase activity of 1-benzyl-4-[2-(N-benzoylamino)ethyl]piperidine derivatives, J. Med. Chem.   33 (1990) 1880-1887. I. T. Lott, K. Osann, E. Dorn and L. Nelson, Down syndrome and Alzheimer disease: response to donepezil, Arch. Neurol.   59 (2002) 1133-1136. S

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Mariusz Stolarczyk, Anna Apola, Anna Maślanka, Anna Kwiecień and Włodzimierz Opoka

Bossche, Optimization and validation of a micellar electrokinetic chromatographic method for the analysis of several angiotensin-II-receptor antagonists, J. Chromatogr. A 984 (2003) 135-146; https://doi.org/10.1016/S0021-9673(02)01832-0 12. S. Zargar and T. A. Wani, New UPLC-MS/MS method for simultaneous determination of telmisartan and hydrochlorthiazide in human plasma, Lat. Am. J. Pharm. 33 (2014) 432-440. 13. E. Şatana, S. Altinay, N. G. Göger, S. A. Özkan and Z. Şentürk, Simultaneous determination of valsartan and

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J. Rovenský, T. Urbánek and R. Imrich

pigmentation associated with the use of atabrine. Illinois Med J 1946; 89: 234-242. [31] Suwannarat P, O'Brien K, Perry MB, et al. Use of nitisinone in patients with alkaptonuria. Metabolism 2005; 54: 719-728. [32] Trnavská Z. Amino-acids in alkaptonuia. In: Congres-sus rheumatologicus checoslovacus in Thermis Piešt'any 1960. Lenoch F, et al (eds). SzdN, Praha 1962; 99-104. [33] Turgay E, Canat D, Gurel MS, el al. Endogenous ochrono-sis. Clin Exp Dermatol 2009; 34: 865-868. [34] Urbánek T, Sit'aj Š. Súčasný výskyt alkaptonúrie, ochro-notickej artropatie a choroby

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Ana Budimir

. Markesbery, Copper, iron, and zinc imbalances in severely degenerated brain regions in Alzheimer's disease: possible relation to oxidative stress, J. Neurol. Sci.   143 (1996) 137-142; DOI: 10.1016/S0022-510X(96)00203-1. M. C. Boll, M. Alcaraz-Zubeldia, S. Montes and C. Rios, Free copper, ferroxidase and SOD1 activities, lipid peroxidation and NO(x) content in the CSF. A different marker profile in four neurodegenerative diseases, Neurochem. Res.   33 (2008) 1717-1723; DOI: 10.1007/s11064-008-9610-3. I. Maurer, S

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Ajit A. Patil, Sachin S. Bhusari, Devanand B. Shinde and Pravin S. Wakte

pyrolyser-gas chromatography-mass spectrometry, Environ. Res . 104 (2007) 209-215; DOI: 10.1016/j.envres. 2004.06.008. 27. A. A. Patil, B. S. Sachin, D. B. Shinde and P. S. Wakte, Supercritical CO2 assisted extraction and LC-MS identification of picroside I and picroside II from Picrorhiza kurroa, Phytochem. Anal. 24 (2013) 97-104; DOI: 10.1002/pca.2383. 28. A. Erkucuk, I. H. Akgun and O. Yesil-Celiktas, Supercritical CO2 extraction of glycosides from Stevia rebaudiana leaves: Identification and optimization, J. Supercrit. Fluids

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Ziyaur Rahman, Sohail Akhtar, Akhtar Siddiqui, Anthony B. Ciavarella, Agnes Nguyenpho, Patrick J. Faustino and Mansoor A. Khan

. 3. US Food&Drug Administration, CFR - Code of Federal Regulations, Title 21 - Food and Drugs, Chapter I - Food and Drug Administration, Subchapter D - Drugs for Human Use, Part 320 - Bioavailability and Bioequivalence Requirements, Subpart B - Procedures for Determining the Bioavailability or Bioequivalence of Drug Products, Sec. 320.33 - Criteria and Evidence to Assess Actual or Potential Problems, Department of Health and Human Services, Silver Spring (MD) 2017, Vol. 5; https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=320.33; last acces

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Senar Aydin, Mehmet Emin Aydin, Fatma Beduk, Arzu Tekinay and Havva Kilic

REFERENCES 1. N. A. Alygizakis, P. Gago-Ferrero, V. L. Borova, A. Pavlidou, I. Hatzianestis and N. S. Thomaidis, Occurrence and spatial distribution of 158 pharmaceuticals, drugs of abuse and related metabolites in offshore seawater, Sci. Total Environ . 541 (2016) 1097–1105; https://doi.org/10.1016/j.scitotenv.2015.09.145 2. J. Martín, M. D. Camacho-Muñoz, J. L. Santos, I. Aparicio and E. Alonso, Distribution and temporal evolution of pharmaceutically active compounds alongside sewage sludge treatment. Risk assessment of sludge application onto

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Olajumoke A. Oyebode, Ochuko L. Erukainure, Neil A. Koorbanally and Md. Shahidul Islam

.3 13. J. C. Ikewuchi, E. N. Onyeike, A. A. Uwakwe and C. C. Ikewuchi, Effect of aqueous extract of the leaves of Acalypha wilkesiana ‘Godseffiana’ Muell Arg (Euphorbiaceae) on the hematology, plasma biochemistry and ocular indices of oxidative stress in alloxan induced diabetic rats, J. Ethnopharmacol. 137 (2011) 1415-1424; https://doi.org/10.1016/j.jep.2011.08.015 14. U. Odoh, R. I. Ndubuokwu, S. I. Inya-Agha, P. O. Osadebe, P. F. Uzor and M. Ezejiofor, Antidiabetic activity and phytochemical screening of Acalypha wilkesiana (Euphorbiaceae) Mull Arg

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Milan Grundmann, Ivana Kacirova and Romana Urinovska

References 1. M. Grundmann and I. Kacirova, Significance of TDM, phenotyping and genotyping for the correct drug dosage, Cas. Lek. Ces. 149 (2010) 482-487. 2. M. Grundmann, I. Kacirova and R. Urinovska, Therapeutic monitoring of psychoactive drugs - antidepressants: A review, Biomed. Pap. Med. Fac. Univ. Palacky Olomouc Czech Repub. (2013) in press; DOI: 10.5507/bp.2013.020. 3. I. Kacirova, M. Grundmann and R. Urinovska, General principles of therapeutic monitoring of psychoactive drugs, Klin. Farmakol. Farm. 26