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Wang Zhen-fei, Liu Li, Liang Lin and Hao Qin

”, “softening hardness and loosing knot”, and so on. Some low-toxic and nontoxic Chinese herbs have played a role in tumor treatment [ 4 ]. Radix Glehniae is a commonly used nontoxic herb with the functions of “Yang yin qing fei”, promoting the secretion of saliva or body fluid, and “expelling phlegm and arresting cough”. It is useful for treating lung diseases and has been widely used in prescriptions against lung cancer [ 5 ]. Here, for the first time, we investigated the effect of Radix Glehniae on the migration and invasion abilities of lung cancer cells, as well as

Open access

Muyao Zhang, Xing Wei and Zhenfei Wang

cell cycle progression and cell growth. After transfection into hepatocytes, HBx protein upregulates the expression of c-myc, which downregulates the expression of miR-16/15 and then induces a series of malignant behaviors, such as proliferation, migration, and invasion of hepatocytes [ 8 ]. It can be seen that changing miRNA expression is an important mechanism by which HBx protein promotes the malignant transformation of hepatocytes. Alpha-fetoprotein (AFP) is a protein expressed early in HCC. Xia et al. [ 9 ] found that in the HBx-induced hepatocyte malignant

Open access

Yu Zhao

, cancer cells have signaling molecules similar to those of the innate immune system, such as chemokines and cytokines. It has been accepted that inflammation cells have strong effects on cancer development [ 2 , 4 , 5 ]. The inflammatory cells, and the chemokines and cytokines that they produce, influence the whole tumor organ, regulating the growth, differentiation, and migration of all cells in the cancer microenvironment, including neoplastic cells, endothelial cells, and fibroblasts [ 6 , 7 ]. In the tumorigenic process, neoplastic cells also divert inflammatory

Open access

Ren-wen Zhang, Yong Qiao, Xiao-hua Hao, Hong-min Li, Hui Ren, Xiao-jing Zhang, Hong-shan Wei and Xiao-yuan Xu

L, You H, Zhang P, Du W, et al. Role of hepatitis B virus X protein in regulating LIM and SH3 protein 1 (LASP-1) expression to mediate proliferation and migration of hepatoma cells. Virol J 2012; 9:163. 5. Guidotti LG, Chisari FV. Immunobiology and pathogenesis of viral hepatitis. Annu Rev Pathol 2006; 1:23-61. 6. Li GL, Wei HS, Song SJ. The effect of angiotensin II on the gene expression of hepatic stellate cells. Zhonghua Gan Zhang Bing Za Zhi (Chin) 2006; 14(12):914-919. 7. Feng JY, Shao JG. The current state on

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Shujun Ma

Microbiol, 2002, 10(6):293-299. 29 Shah AA, Mayank M, Mulla AF. Evolving role of bacteria in oral cancer. Univer Res J Dent, 2012, 2(3):103. 30 Park JH, Yoon HE, Kim DJ, et al . Toll-like receptor 5 activation promotes migration and invasion of salivary gland adenocarcinoma. J Oral Pathol Med, 2011, 40(2):187-193. 31 Kauppila JH, Mattila AE, Karttunen TJ, et al . Toll-like receptor 5 and the emerging role of bacteria in carcinogenesis. Oncoimmunology, 2013, 2(4): e23620. 32 Ancelle-Park R. Expanded European AIDS case definition. Lancet, 1993, 341

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Su-zhen Jiang, Jia-jia Zheng, Xiang-Mei Chen, Ting Zhang, Qiang Xu, Hui Zhuang and Fengmin Lu

and calreticulin prevent oxidative stress, Ca2+ disturbances, and cell death in renal epithelial cells. J Biol Chem 1997;272:21751-21759. 38 Lu HH, Chen HA, et al. Survivin-mediated cancer cell migration through GRP78 and epithelial-mesenchymal transition (EMT) marker expression in mahlavu cells. Ann Surg Oncol 2012;19:336-343. 39 Cohen M, Petignat P. Purified autoantibodies against glucoseregulated protein 78 (GRP78) promote apoptosis and decrease invasiveness of ovarian cancer cells. Cancer Lett 2011;309:104-109. 40

Open access

Sheng Hao

metastasis of tumor cells and promote the epithelial–mesenchymal transition that further promotes the development and invasion of tumor [ 16 , 17 ]. ROS produced by NOX4 activates STAT3/5 and promotes the HIF-1α/HIF-2α expression and then the development of tumor [ 18 , 19 ]. In summary, NADPH and NADPH oxidase are closely related to colonization, invasion, metastasis and apoptosis of tumor cells. 3 NADPH promotes tumor cell proliferation and migration ROS regulates HIF-1α by signal transducer and activator of transcription 3 (STAT3) signal pathway, a member of the

Open access

Hua Feng

L., Abdi Y., Graham JY, Hardie JM, Feldman RA, Migration and Helicobacter pylori seroprevalence: Bangladeshi migrants in the UK, J. Infect., 1995, 31, 133-135. 10.1016/S0163-4453(95)92135-4 Banatvala N. Clements L. Abdi Y. Graham JY Hardie JM Feldman RA Migration and Helicobacter pylori seroprevalence: Bangladeshi migrants in the UK J. Infect. 1995 31 133 135 [7] Mégraud F., Epidemiology of Helicobacter pylori infection, Gastroenterol. Clin. North Am., 1993, 22, 73-88. Mégraud F. Epidemiology of Helicobacter pylori infection Gastroenterol. Clin. North Am

Open access

Zhi-Jian Li, Xing-Ling Sui, Xue-Bo Yang and Wen Sun

significantly enriched in immune response ( P =1.59E–21), leukocyte activation ( P = 4.67E–18), and cell activation ( P =8.94E–18). In experiment 2, DEGs mainly participated in defense response ( P =7.44E–10), leukocyte migration ( P =5.86E–09), and immune response ( P =5.88E–09). In experiment 3, the results showed that the biological functions enriched by DEGs were related to immune response ( P =2.98E–21), leukocyte activation ( P =1.34E–14), and cell activation ( P = 6.33E–13). In experiment 4, we concluded that the biological terms were associated with chromosome

Open access

Zhe An

. The initiation of signaling in endothelial cells requires PDZK1, an adapter protein containing four PDZ domains that recognize the C-terminal domain of SR-BI [ 7 ]. The interaction of PDZK1 with SR-BI in the liver significantly affects the metabolism and structure of plasma HDL. PDZK1 is crucial for the activation of many downstream signaling pathways of HDL-mediated Src phosphorylation and SR-BI-mediated HDL stimulation, such pathways include Src activation, eNOS phosphorylation, cell migration, and carotid artery reendothelialization after perivascular electrical