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Edyta Klimczak-Jajor, Joanna Skulimowska, Anna Ejduk, Katarzyna Guz, Małgorzata Uhrynowska and Ewa Brojer

evidence of iron deficiency. She had been given oral iron suplementation several times. Family history of hereditary anemia is unavailable. Biochemical analysis for quantization of HbA 2 and HbF was normal but band migration with HbS position on alkaline electrophoresis and additional band on acid electrophoresis suggest that the patient has hemoglobinopathy. It is noteworthy that the presence of band migration at the HbS position on alkaline agarose gel can lead to misdiagnosis in the diagnostic schedules for thalassemia/hemoglobinopathy. We performed the sequencing

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Samia Abd El-Moneim Ebied, Nadia Aly Sadek, Nadia El-Sayed Zaki, Samir Ali Abd El- Kaream and Heba Khafagui Ahmed El Kashif

binds to either Ang II-type 1 receptors (AGTR1) or Ang II-type 2 receptors (AGTR2). The AGTR1 and AGTR2 can act as antagonists, and mediate effects on cell migration and proliferation of metastatic cancer cells and hemopoietic stem-progenitor cells [ 7 ]. Components of the RAS are frequently differentially expressed in various cancers in comparison with their corresponding non-malignant tissue. In particular, over-expression of AGTR1 [ 3 ]. Studies of knockout mice for ACE as well as other RAS components such as angiotensinogen, renin, AGTR1 and AGTR2 have further

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Mateusz Nowicki, Piotr Stelmach and Anna Szmigielska-Kapłon

tumor development by promoting vascular and lymphatic angiogenesis [ 10 ]. PGF stimulates angiogenesis in physiological condition and during cancer development [ 11 ]. VEGF-A (hereafter referred to as VEGF) binds to vascular endothelial growth factor receptor 1 and 2 (VEGFR-1, VEGFR-2) and is a key regulator of EC proliferation, migration, and adherence [ 8 ]. Other important receptors for VEGF are neuropilin 1 and 2 receptors (NRP1 and NRP2). This cytokine stimulates angiogenesis via binding with NRP1 and enhances VEGF/VEGFR2 activation [ 12 ]. In epidermal cancer