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Aleksandra Świercz, Sylwia Lewandowska, Krzysztof Szaflik, Adam Oleś, Anna Piaseczna-Piotrowska and Maria Respondek Liberska


Shunt implantation in utero being a life-saving procedure, may be connected with a wide range of complications. One of them is catheter dislocation, a side effect which may impair the state of the fetus and child. We present a case of a boy with Congenital Adenomatoid Lung Malformation (CALM) type II. Invasive prenatal therapy, complicated by shunt migration did not influence our patient’s health. Moreover, the abnormally located shunt stayed within the child’s chest up to the age of 6 years. No symptoms linked to foreign body presence were observed. Although similar cases were published, we report a situation, in which the catheter was left in the patient’s body for 6 years, for the first time.

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Tetsuya Goto, Chika Ndubuisi, Tatsuya Kobayashi, Takafumi Kiuchi, Kunihiko Kodama, Keiichi Sakai and Kazuhiro Hongo

. In the present case, the NIRS was only used after the fifth surgery. However, it is possible that if the NIRS was used earlier around the third or fourth perioperative period, with a reliable confirmation of migration of the right motor function to opposite side, the option of a more aggressive tumor removal may have been attempted at that time. Further clinical studies are required for better understanding of the clinical relevance of NIRS investigation in the pre-operative monitoring for areas of eloquence and the concept of brain plasticity. 4 Conclusion

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Edyta Klimczak-Jajor, Joanna Skulimowska, Anna Ejduk, Katarzyna Guz, Małgorzata Uhrynowska and Ewa Brojer

evidence of iron deficiency. She had been given oral iron suplementation several times. Family history of hereditary anemia is unavailable. Biochemical analysis for quantization of HbA 2 and HbF was normal but band migration with HbS position on alkaline electrophoresis and additional band on acid electrophoresis suggest that the patient has hemoglobinopathy. It is noteworthy that the presence of band migration at the HbS position on alkaline agarose gel can lead to misdiagnosis in the diagnostic schedules for thalassemia/hemoglobinopathy. We performed the sequencing

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Samia Abd El-Moneim Ebied, Nadia Aly Sadek, Nadia El-Sayed Zaki, Samir Ali Abd El- Kaream and Heba Khafagui Ahmed El Kashif

binds to either Ang II-type 1 receptors (AGTR1) or Ang II-type 2 receptors (AGTR2). The AGTR1 and AGTR2 can act as antagonists, and mediate effects on cell migration and proliferation of metastatic cancer cells and hemopoietic stem-progenitor cells [ 7 ]. Components of the RAS are frequently differentially expressed in various cancers in comparison with their corresponding non-malignant tissue. In particular, over-expression of AGTR1 [ 3 ]. Studies of knockout mice for ACE as well as other RAS components such as angiotensinogen, renin, AGTR1 and AGTR2 have further

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Mateusz Nowicki, Piotr Stelmach and Anna Szmigielska-Kapłon

tumor development by promoting vascular and lymphatic angiogenesis [ 10 ]. PGF stimulates angiogenesis in physiological condition and during cancer development [ 11 ]. VEGF-A (hereafter referred to as VEGF) binds to vascular endothelial growth factor receptor 1 and 2 (VEGFR-1, VEGFR-2) and is a key regulator of EC proliferation, migration, and adherence [ 8 ]. Other important receptors for VEGF are neuropilin 1 and 2 receptors (NRP1 and NRP2). This cytokine stimulates angiogenesis via binding with NRP1 and enhances VEGF/VEGFR2 activation [ 12 ]. In epidermal cancer