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Goran Pavlisa, David Ozretic, Marko Rados and Gordana Pavlisa

Migration of Enterprise stent in treatment of intracranial aneurysms: a report of two cases

Background. We present two patients with acutely ruptured complex aneurysms of the internal carotid artery, arising at the origin of the posterior communicating artery (PComA).

Case reports. The aneurysms in both patients had a wide neck and the closed-cell stent (Enterprise) was delivered to assist in aneurysm coiling. In both patients an inadvertent migration of stent occurred, without periprocedural complications. Aneurysms were successfully embolized by endovascular coils.

Conclusions. These cases highlight the flexibility of the stent, as well as the likelihood of stent migration in the setting of immediate coiling after the placement of stent, or in adverse anatomic relations.

Open access

Lin Fang, Hai-Bing Zhang, Hua Li, Yong Fu and Guang-Shun Yang

miR-548c-5p inhibits proliferation and migration and promotes apoptosis in CD90+ HepG2 cells

Background. Since the introduction of the theory of tumour stem cells (TSCs), the liver cancer stem cell (LCSC)-like cells have become one of the focuses in the research on liver cancer.

Materials and methods. In this study, CD90+ cells were applied as the possible LCSC-like cells, and the miRNA and gene expression were analyzed in the CD90+ HepG2 cells. The pilot study showed miR-548c-5p exerted potential effect on the CD90+ HepG2 cells and was thereafter applied for the further study. CD90+ HepG2 cells were assigned to miR-548c-5p mimic transfection group and control group. MTT assay was performed to detect the proliferation of CD90+ HepG2 cells. The migration and invasion abilities were examined by wound healing assay and transwell migration assay, respectively. A detection of apoptosis was performed by fluorescence microscopy.

Results. Our results showed that caspase-3 and bcl-2 were down-regulated while caspase-8 was up-regulated in the CD90+ HepG2 cells. Moreover, the miR-548c-5p transfection could down-regulate the expression of β-catenin, Tg737, bcl-2, bcl-XL, and caspase-3, inhibit the proliferation, migration and invasion and promote the apoptosis of the CD90+ HepG2 cells.

Conclusions. Our findings indicate the imbalance between apoptosis and anti-apoptosis in the LCSC-like cells, which influence the biological features of LCSC-like cells. miRNA plays a regulatory role in the LCSC-like cells among which miR-548c-5p might be a suppressor.

Open access

Zoran Vulićević, Miloš Beloica, Dušan Kosanović, Ivana Radović, Jelena Juloski and Dragan Ivanović


Premature loss of teeth in children may lead to both functional and esthetic problems. Missing teeth in both anterior and posterior regions may cause malfunctions in mastication and proper pronunciation. If the missing teeth are not replaced, further complications may occur, including adjacent tooth migration, loss of alveolar bone, and irregular occlusion. Considering the sensitive nature of children, loss of teeth may cause the development of insecurities and low self esteem problems. Due to dynamic nature of growth in children and adolescents, prosthetic appliances must not hinder development of orofacial system, and must meet adequate esthetic and functional standards. Dental prosthetic appliances in paediatrics must be planned with respect to the special conditions that led to tooth loss or damage. Multi-disciplinary approach is needed, under constant supervision of paediatric dentist and orthodontist, as well as regular checkups with clinical and radiographical examinations.

Open access

Bosiljka Djuricic

Brucellosis in the Republic of Serbia - The Epizootiological Situation

Aim. To present seroprevalence data of the brucellosis in livestock in Serbia.

Methods. The classical serological diagnostic methods were used: Rose Bengal (RB) for screening, Complement Fixation Test (CFT) and Indirect ELISA as confirmatory tests.

Results. Brucellosis in livestock is present in some regions in Serbia. During the period from 2003 to 2007, the prevalence of brucellosis in sheep was 19.5%-73% (26.8%), in goats 0%-67.1% (35%), in cattle 0%-36.1% (4.8%), and in pigs 0%-16.4% (5.8%). During 2004 new foci of brucellosis in livestock and humans were discovered in the territories of Srednjebanatski and Zapadnobacki counties. By the end of 2004, new foci were registered on the territory of 10 communities from five counties and brucellosis cases were diagnosed in 12 settlements. Actual epizootiological situation during the period from 2007 to 2009 in Serbia was additionally complicated both by the increased number of registered cases and remarcable number of newly affected areas.

Conclusion. Brucellosis in Serbia during the last decade shows some specific characteristics such as rapid spread and easy transmission, and persistence. Outbreaks in new localities and increase of human cases were observed. The increase of brucellosis in the southern part of Serbia was facilitated by the border porosity and lack of control of animal movements toward Kosovo and Metohia territories and migration of infected sheep.

Open access

J Stilla, D Statelova, M Janickova, I Malachovsky, P Gengelova, J Jurkemik and K. Adamicova

tooth extraction socket, inhibits oral epithelial cell migration and promotes proliferation and adhesion to hydroxyapatite of oral bacteria, withou causing osteonecrosis, in mice. J Bone Miner Metab 2010 (28):165-175. 20. Hansen T, Kunkel M, Springer E, Walter C, Weber A, Siegel E, Kirkpatrick CJ. Actinomycosis of the jaws - histopathological study of 45 patients shows involvement in bisphophonate-associated osteonecrosis and infected osteoradionecrosis. Virchows Arch. 451:1009-1017, 2007 21. Gliklich R, Wilson J. Epidemiology of

Open access

Wafaa M. Ezzat, Halla M. Ragab, Nabila Abd El Maksoud, Nour A. Abdulla and Yasser A. Elhosary

B, Westermann AM, et al. Plasma lysophosphatidic acid concentration and ovarian cancer. JAMA : the journal of the American Medical Association. 2002;287(23):3081-2. 31. Li H, Wang D, Zhang H, Kirmani K, Zhao Z, Steinmetz R, et al.Lysophosphatidic acid stimulates cell migration, invasion, and colony formation as well as tumorigenesis/metastasis of mouse ovarian cancer in immunocompetent mice. Molecular cancer therapeutics. 2009;8(6):1692-701. 32. Stracke ML, Clair T, Liotta LA. Autotaxin, tumor motilitystimulating

Open access

I. Zila and A. Calkovska

, Mortola JP. Hering-Breuer reflex in conscious newborn rats: effect of changes in ambient temperature during hypoxia. J Appl Physiol 1999; 87(5): 1656-61. Werner MF, Fraga D, Melo MC, Souza GE, Zampronio AR. Importance of the vagus nerve for fever and neutrophil migration induced by intraperitoneal LPS injection. Inflamm Res 2003; 52: 291-6. Schoener EP, Frankel HM. Effect of hyperthermia and PaCO 2 on the slowly adapting pulmonary stretch receptor. Am J Physiol 1972; 222(1):68-72. Žila I

Open access

George Fotopoulos, Ioannis Vathiotis, George C. Nikou and Konstantinos Syrigos

NETs and tumorigenesis is not well established but one could argue that the interaction with the homolog acting as tumor suppression is altered thus leading to tumorigenesis. In the same region lies the ZNF322A gene encoding a classical Cys2His2 zinc finger transcription factor. Although it has been associated with lung cancer formation, evidence remains controversial. ZNF322A gene upregulation boosted cell proliferation, migration and invasion. Furthermore, its knockdown diminished cell growth, invasion and also metastasis both in vitro and in vivo. Alpha

Open access

R. Sklavenitis-Pistofidis, T. Koletsa, A. Lazaridou and A. Goulas

-cell migration and adhesion.[ 21 , 22 ] Figure 2 B-cell Receptor (BCR) signalling pathway. Lyn, Syk: Src-family tyrosine kinases. PI3K: Phosphoinositide 3-kinase. PIP 2 : Phosphatidylinositol 4,5-biphosphate. PIP 3 : Phosphatidylinositol 3,4,5-triphosphate. BLNK: B-cell linker protein. PLCγ2: Phospholipase C γ-2. DAG: Diacylglycerol. PKC: Protein kinase C. NF-κB: Nuclear factor kappa B. BCR consists of a membrane immunoglobulin (mIg), noncovalently associated with Ig-α (CD79a) and Ig-β (CD79b), which contain immunoreceptor tyrosine-based activation motif

Open access

E. Veniou, I. Sofatzis, I. Kalantzis, M. Karakosta, M. Logothetis, E. Lianos and N. Ziras

breast and colon cancers. However, it is not clear if the antioxidant effect itself is sufficient to justify their anti-cancer properties. AGEs have a receptor (RAGE), belonging to the superfamily of immunoglobulins and can bind multiple ligands, including AGEs as well as amphoterin, an important protein involved in the regulation of inflammation, oncogenesis and cellular differentiation and migration. The receptor is expressed in many cancers such as colon, pancreatic and prostate cancer, but not in lung and esophageal cancer. Binding of AGEs causes genotoxic effect