Alenka Franko, Nika Kotnik, Katja Goricar, Viljem Kovac, Metoda Dodic-Fikfak and Vita Dolzan
and catalase genetic polymorphism. Arh Hig Rada Toksikol 2008; 59 : 233-40. 10.2478/10004-1254-59-2008-1907 Franko A Dolžan V Arnerić N Dodič-Fikfak M. Asbestosis and catalase genetic polymorphism Arh Hig Rada Toksikol 2008 59 233 40 10.2478/10004-1254-59-2008-1907
17 Chuang T-C, Liu J-Y, Lin C-T, Tang Y-T, Yeh M-H, Chang S-C, et al. Human manganese superoxide dismutase suppresses HER2/neu-mediated breast cancer malignancy. FEBS Lett 2007; 581 : 4443-9. 10.1016/j.febslet.2007.08.021 Chuang T-C Liu J-Y Lin C-T Tang Y-T Yeh M-H Chang S-C Human manganese
Ana Lina Vodusek, Katja Goricar, Barbara Gazic, Vita Dolzan and Janez Jazbec
antioxidant enzymes such as superoxide dismutase (SOD), glutathione peroxidase (GPX) and catalase (CAT). Manganese superoxide dismutase (SOD2) is the major antioxidant in mitochondria, catalysing the dismutation of superoxide anion to H 2 O 2 , which is then reduced to water by CAT or GPX. 20 , 21 Many studies have investigated genetic variability in genes coding for antioxidant enzymes and their relationship to cancer risk, however the results were inconclusive 22 and the data on thyroid cancer risk are lacking. 23
The most common polymorphism in the gene coding for
Blaz Krhin, Katja Goricar, Barbara Gazic, Vita Dolzan and Nikola Besic
, complex defence mechanisms including many enzymes, proteins and antioxidants are involved. Antioxidant enzymes such as manganese superoxide dismutase (Mn-SOD), glutathione peroxidase (GPX) and catalase (CAT) directly eliminate ROS, while glutathione-S-transferases (GSTs) detoxify cytotoxic secondary metabolites. Numerous functional polymorphisms in the genes coding for antioxidant enzymes have been described that may also modify their ROS detoxification capacity. 17
Oxidative stress and ROS have been associated with several cancers and also many complex diseases like
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Alexiou C, Jurgons R. Magnetic drug
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Kiss B, Biro T, Czifra G, Toth BI