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Alenka Franko, Nika Kotnik, Katja Goricar, Viljem Kovac, Metoda Dodic-Fikfak and Vita Dolzan

and catalase genetic polymorphism. Arh Hig Rada Toksikol 2008; 59 : 233-40. 10.2478/10004-1254-59-2008-1907 Franko A Dolžan V Arnerić N Dodič-Fikfak M. Asbestosis and catalase genetic polymorphism Arh Hig Rada Toksikol 2008 59 233 40 10.2478/10004-1254-59-2008-1907 17 Chuang T-C, Liu J-Y, Lin C-T, Tang Y-T, Yeh M-H, Chang S-C, et al. Human manganese superoxide dismutase suppresses HER2/neu-mediated breast cancer malignancy. FEBS Lett 2007; 581 : 4443-9. 10.1016/j.febslet.2007.08.021 Chuang T-C Liu J-Y Lin C-T Tang Y-T Yeh M-H Chang S-C Human manganese

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Ana Lina Vodusek, Katja Goricar, Barbara Gazic, Vita Dolzan and Janez Jazbec

antioxidant enzymes such as superoxide dismutase (SOD), glutathione peroxidase (GPX) and catalase (CAT). Manganese superoxide dismutase (SOD2) is the major antioxidant in mitochondria, catalysing the dismutation of superoxide anion to H 2 O 2 , which is then reduced to water by CAT or GPX. 20 , 21 Many studies have investigated genetic variability in genes coding for antioxidant enzymes and their relationship to cancer risk, however the results were inconclusive 22 and the data on thyroid cancer risk are lacking. 23 The most common polymorphism in the gene coding for

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Blaz Krhin, Katja Goricar, Barbara Gazic, Vita Dolzan and Nikola Besic

, complex defence mechanisms including many enzymes, proteins and antioxidants are involved. Antioxidant enzymes such as manganese superoxide dismutase (Mn-SOD), glutathione peroxidase (GPX) and catalase (CAT) directly eliminate ROS, while glutathione-S-transferases (GSTs) detoxify cytotoxic secondary metabolites. Numerous functional polymorphisms in the genes coding for antioxidant enzymes have been described that may also modify their ROS detoxification capacity. 17 Oxidative stress and ROS have been associated with several cancers and also many complex diseases like

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Sara Prijic and Gregor Sersa

-434. Auffan M, Rose J, Bottero JY, Lowry GV, Jolivet JP, Wiesner MR. Towards a definition of inorganic nanoparticles from an environmental, health and safety perspective. Nat Nanotechnol 2009; 4: 634-41. Gubin S. Introduction. In: Gubin S, editor. Magnetic nanoparticles. Weinheim: Wiley-VCH; 2009. p. 1-24. Bondi JF, Oyler KD, Ke X, Schiffer P, Schaak RE. Chemical synthesis of air-stable manganese nanoparticles. J Am Chem Soc 2009; 131: 9144-5. Alexiou C, Jurgons R. Magnetic drug

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Matej Skocaj, Metka Filipic, Jana Petkovic and Sasa Novak

-35. Wakefield G, Lipscomb S, Holland E, Knowland J. The effects of manganese doping on UVA absorption and free radical generation of micronised titanium dioxide and its consequences for the photostability of UVA absorbing organic sunscreen components. Photochem Photobiol Sci 2004; 37 : 648-52. Pan Z, Lee W, Slutsky L, Clark RA, Pernodet N, Rafailovich MH. Adverse effects of titanium dioxide nanoparticles on human dermal fibroblasts and how to protect cells. Small 2009; 54 : 511-20. Kiss B, Biro T, Czifra G, Toth BI