, Bacchi D. Cooper, zinc, manganese, niacin and pridoxine in the schizophrenias. Appl Nutr. 1975; 27: 9-39. 9. Wolf TL, Kotun J, Meador-Woodruff JH. Plasma copper, iron, ceruloplasmin and ferroxidase activity in schizophrenia. Schizophr Res. 2006; 86: 167-71. 10. Herran A. Higher levels of serum copper in schizophrenic patients treated with depot neuroleptics. Psychiatry Res. 2000; 94: 51-58. 11. Yanik M, Kocyigit A, Tutkun H. Plasma manganese, selenium, zinc, copper, and iron concentrations in patients with schizophrenia
George A. Asare, Ruth Tetteh, Elsie Amedonu, Bernice Asiedu and Derek Doku
Maha I. A. Moaty, Salwa M. El Shebini, Nihad H. Ahmed, Ahmed M. S. Hussein, Magda S. Mohamed, Salwa T. Tapozada and Laila M. Hanna
cholesterol. Clin Chemo. 1974; 20:470- 75. 14. Wornick DF, Albers JJ. A comprehensive evaluation of the heparin-manganese precipitation procedure for estimating high density lipoprotein cholesterol. J Lipid Res.1978; 19:65-76. 15. Seidel J, Klos S, Ziegenhorn T. AACC Meeting Abstract 34.Clin Chem. 1993; 39:1127. 16. Friedewald WI, Levy RI, Fredrickson DS. Estimation of the concentration of low density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem.1972; 18
Mostafa Saadat, Samane Safaie and Iraj Saadat
correlated to blood catalase levels. Free Radic Biol Med. 2001;30:500-505. 4. Ambrosone CB, Ahn J, Singh KK, Rezaishiraz H, Furberg H, Sweeney C, Coles B, Trovato A. Polymorphisms in genes related to oxidative stress ( MPO , MnSOD , CAT ) and survival after treatment for breast cancer. Cancer Res. 2005;65:1105-1111. 5. Tefik T, Kucukgergin C, Sanli O, Oktar T, Seckin S, Ozsoy C.Manganese superoxide dismutase Ile58Thr, catalase C-262T and myeloperoxidase G-463A gene polymorphisms in patients with prostate cancer: relation to advanced and
Maha I. A. Moaty, Salwa M. El Shebini, Magda S. Mohamed, Nihad H. A. El-Arabi, Salwa T. Tapozada and Laila M. Hanna
micro-column procedure. Diabetes. 1978;27:931-937. 24. Barham D, Trinder P. An improved color reagent for determination of blood glucose by oxidase system. Analyst. 1972; 97:142-145. 25. Allain CC, Poon LS, Chan CS, Richmond W, Fu PC Enzymatic determination of total serum cholesterol. Clin Chemo. 1974;20:470- 475. 26. Wornick DF, Albers JJ. A comprehensive evaluation of the heparin-manganese precipitation procedure for estimating high density lipoprotein cholesterol. J Lipid Res.1978;19:65-76. 27. Seidel
Mihaela Posea, Andreea Dragomir and Gabriela Radulian
Background and Aims: The aim of this study was to document the eating habits of normal weight and obese patients in order to implement a new and healthier lifestyle. Material and Methods: We evaluated the intake of energy and that of vitamins and minerals in a sample of 199 normal weight and obese subjects. We also performed anthropometric's measurements, paraclinic’s and laboratory’s tests. Results: The mean intake of vitamins and minerals is significantly different for B1 and B3 vitamins and for iron, phosphorus, copper and selenium. Vitamins like B1, B2, B3, B6, B12, C and A vitamin and minerals like, zinc, manganese, phosphorus and selenium are over consumed in both groups. Regarding the sodium’s intake, only 37.04% of normal weight patients fulfill the recommendations of less than 2 g/day. The prevalence of a high fat diet is about 59.29% in normal weight people and 60.69% among obese ones. Only 25% of normal weight patients had normal abdominal circumference and 58.47% of obese subjects had normal HDL-cholesterol levels. Conclusions: Regardless the body mass index (BMI) status, neither normal weight subjects nor the obese ones' had an adequate micronutrient intake. Also, there is a high prevalence of high sodium’s intake and a high fat diet among the normal weight patients.
Hajar Negahdar, Seyed Reza Hosseini, Hadi Parsian, Farzan Kheirkhah, Abbas Mosapour, Soraya Khafri and Asefeh Hagh Haghighi
Introduction. Mild cognitive impairment (MCI) is the prodromal stage of Alzheimer’s disease (AD), so identification of the related risk factors can be helpful. There are controversial data regarding the serum oxidant/antioxidant status, trace elements and homocysteine (Hcy) as effective parameters in this disease, therefore the status of these factors was determined in this study.
Methods. One hundred-twenty elderly persons with cognitive impairment and 120 elderly healthy persons who were differentiated using Mini-mental state examination (MMSE) participated in this study. The patients were divided into mild and moderate-to-severe cognitive impairment group. Serum antioxidant/oxidant, copper (Cu), manganese (Mn), zinc (Zn) and Hcy concentrations were measured using routine methods.
Results. Oxidant and antioxidant levels increased and decreased based on the severity of the disease and were higher and lower in patients than in control group, respectively (p<0.001). With adjusting for age, gender and education, significant difference in Hcy levels was not observed. There was no significant difference in trace elements levels among groups.
Conclusions. Results confirmed the association between oxidative damage with increasing the severity of cognitive impairment. These factors may be involved in the etiology of cognitive impairment and AD. Identification of such biomarkers is important to select appropriate treatment goals before the onset of irreversible clinical signs.
Alenka Franko, Nika Kotnik, Katja Goricar, Viljem Kovac, Metoda Dodic-Fikfak and Vita Dolzan
and catalase genetic polymorphism. Arh Hig Rada Toksikol 2008; 59 : 233-40. 10.2478/10004-1254-59-2008-1907 Franko A Dolžan V Arnerić N Dodič-Fikfak M. Asbestosis and catalase genetic polymorphism Arh Hig Rada Toksikol 2008 59 233 40 10.2478/10004-1254-59-2008-1907 17 Chuang T-C, Liu J-Y, Lin C-T, Tang Y-T, Yeh M-H, Chang S-C, et al. Human manganese superoxide dismutase suppresses HER2/neu-mediated breast cancer malignancy. FEBS Lett 2007; 581 : 4443-9. 10.1016/j.febslet.2007.08.021 Chuang T-C Liu J-Y Lin C-T Tang Y-T Yeh M-H Chang S-C Human manganese
Ana Lina Vodusek, Katja Goricar, Barbara Gazic, Vita Dolzan and Janez Jazbec
antioxidant enzymes such as superoxide dismutase (SOD), glutathione peroxidase (GPX) and catalase (CAT). Manganese superoxide dismutase (SOD2) is the major antioxidant in mitochondria, catalysing the dismutation of superoxide anion to H 2 O 2 , which is then reduced to water by CAT or GPX. 20 , 21 Many studies have investigated genetic variability in genes coding for antioxidant enzymes and their relationship to cancer risk, however the results were inconclusive 22 and the data on thyroid cancer risk are lacking. 23 The most common polymorphism in the gene coding for
Blaz Krhin, Katja Goricar, Barbara Gazic, Vita Dolzan and Nikola Besic
, complex defence mechanisms including many enzymes, proteins and antioxidants are involved. Antioxidant enzymes such as manganese superoxide dismutase (Mn-SOD), glutathione peroxidase (GPX) and catalase (CAT) directly eliminate ROS, while glutathione-S-transferases (GSTs) detoxify cytotoxic secondary metabolites. Numerous functional polymorphisms in the genes coding for antioxidant enzymes have been described that may also modify their ROS detoxification capacity. 17 Oxidative stress and ROS have been associated with several cancers and also many complex diseases like
Farid Berroukeche, Nassima Mokhtari-Soulimane, Asmahan Imessaoudene, Ahmed Sabri Cherrak, Pascale Ronot, Anne Boos, Amina Belhandouz, Hafida Merzouk and Mourad Elhabiri
overload on manganese, zinc, and copper concentration in rat tissues in vivo: study of liver, spleen, and brain. Int J Clin Lab Res 28: 183-186, 1998. 45. SandstroÈm B . Micronutrient interactions: effects on absorption and bioavailability. Br J Nutr 85: S181-S185, 2001. 46. Johnson WT, Evans GW . Effects of the interrelationship between dietary protein and minerals on tissue content of trace metals in streptozotocin-diabetic rats. J Nutr 114: 180-190, 1984. 47. Raz I, Adler J, Havivi E . Altered tissue content of trace metals in diabetic