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Associations of vascular calcification, calcium phosphate disturbances, FGF 23 and Matrix Gla protein with mortality of hemodialysis patients: one center cohort study

Abstract

Background and objectives: Vascular calcification (VC) is one of the factors associated with mortality in hemodialysis (HD) patients. The purpose of the study was to assess associations between prevalent VC and disturbances of calcium-phosphate metabolism as well as changes in vitamin D (25(OH)D), FGF 23 and MGP levels and to evaluate the possible impact of VC and changes of these biomarkers on survival in HD patients.

Methods: The study population consisted of 81 prevalent patients in the hemodialysis unit of Hospital of Lithuanian University of Health Sciences Kaunas Clinics. A simple vascular calcification score (SVCS) was evaluated as it is described by Adragao et al. 25(OH)D (nmol/L), FGF 23 (ng/L) and MGP (ng/mL) were measured and analysed.

Results: Patients were divided into two groups: SVCS<3 (31 patient (38.3%) and SVCS ≥3 (50 patients (61.7%)). In multivariate logistic regression, age (odds ratio 1.062, 95% CI [1.024-1.1] p=0.001) and diabetes (odds ratio 6.9, 95% CI [1.5-31], p=0.012) were associated with SVCS ≥3. The multivariate logistic regression revealed the highest negative impact of SVCS ≥3, age and 25(OH)D level for death risk.

Conclusion: VC in HD patients is highly influenced by age and presence of diabetes and associated with higher risk of death. No significant association was found between MGP and FGF 23 and VC as well as between these two biomarkers and risk of death. Lower 25(OH)D levels were associated with mortality in this dialysis patients cohort.

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Is new spread of the European beaver in Pannonian basin an evidence of the species recovery?

-introduction in Hungary. Pp. 211–215. In: Soorae PS, editor. Global re-introduction perspectives: 2016. Case-studies from around the globe, Publisher: IUCN/SSC Re-introduction Specialist Group, Gland, Switzerland & Environment Agency-Abu Dhabi, Abu-Dhabi, UAE. Balčiauskas, L. & Ulevičius, A. (1995) Semi-aquatic mammal environment correlates in South Lithuanian river valleys. Ekologija, 2, 37–44. Bera, M. (2007) Eurázsiaihód (Castor fiber Linnaeus, 1758). In: Bihari, Z., Csorba, G. & Heltai, M.(eds.) Magyarország emlőseinek atlasza. Kossuth Kiadó, Budapest, pp. 152–154. (in

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Occurrence and dynamics of Impatiens parviflora depending on various environmental conditions in the protected areas in Slovakia

–117. Pimentel, D., Lach, L., Zuniga, R. & Morrison, D. (2000) Environmental and economic costs of nonindigenous species in the United States. Bioscience, 50, 53–65. Piskorz, R. (2005) The effect of oak-hornbeam diversity on flowering and fruiting of Impatiens parviflora DC. Roczniky Akademii Rolniczej w Poznaniu, 9, 187–196. Renčo, M. & Baležentiené, L. (2015) An analysis of soil free-living and plant-parasitic nematode communities in three habitats invaded by Heracleum sosnowskyi in central Lithuania. Biol Invasions, 17(4), 1025–1039. Richardson, D

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