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. Research on genetic disorders such as LPLD and ADA-SCID aim to develop treatments for these kinds of genetic diseases that have high rates of morbidity and mortality. Alipogene tiparvovec (brand name Glybera), is a gene therapy product indicated for the treatment of LPLD, which was approved for use in the EuropeanUnion on March 8, 2004 [ 1 ], and to date has only successfully treated one patient. After Glybera, Strimvelis was the second gene therapy approved by European Medicines Agency (EMEA) for the treatment of ADA-SCID [ 2 ]. It was the first instance of marketing
DS Minchev, NT Popov, SI Naimov, IN Minkov and TI Vachev
Professor I. Ivanov (Department of Pediatrics and Medical Genetics, Medical University of Plovdiv, Plovdiv, Bulgaria) for their technical insights and support of this study.
Declaration of Interest . The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.
Funding . This project received funding from the EuropeanUnion's Horizon 2020 research and innovation program under grant agreement No. 739582 (Project PlantaSYST).
1 Leonard LB. Children with specific language
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Lachenmeier DW, Schoeberl K, Kanteres F, Kuballa T, Sohnius E-M, Rehm J. Is contaminated unrecorded alcohol a health problem in the Europeab Union? A review of existing and methodological outline for future sdudies. Addiction 2011;106(Suppl 1):20-30.
Jendral JA, Monakhova YB
Ivica Prlić, Ana Mostečak, Marija Surić Mihić, Želimir Veinović and Luka Pavelić
The ERICA project (Environmental Risk from Ionising Contaminants: Assessment and Management) was co-funded by the European Union as part of the 6th Framework Programme (FP EURATOM). The project was carried out between 2004 and 2007 as the collective work of 15 organisations in seven European countries. Two significant outputs of the project are the ERICA Integrated Approach and the ERICA Tool. The ERICA Integrated Approach consists of three elements: assessment, risk characterisation and management. The ERICA Tool is a practical implementation of the assessment component of the ERICA Integrated Approach and has a three-tier structure. The aim of this review paper is to give a concise overview of ERICA project outputs and their structure, updates done since their first release in 2007, as well as to provide a context for their practical application in environmental radiation protection and radiological risk assessments for various engineering scenarios.
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