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Stefan Janssen, Heinke C Hansen, Liesa Dziggel, Steven E Schild and Dirk Rades

latter group will likely live long enough to experience WBRT-associated late toxicities including neuro-cognitive impairment, WBRT should be given with doses per fraction of less than 3.0 Gy. 6 In addition, hippocampal sparing and administration of memantine are helpful in preserving cognition. 7 , 8 , Thus, it is important to be able to judge an individual patient’s OS prognosis to select the optimal WBRT-regimen. Several scoring systems were developed for patients to be treated for cerebral metastases. To go one step further and allow for even better

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Dimitrij Kuhelj, Anita Dobrovolec and Igor Jozef Kocijancic

Introduction Number of adults burdened by acute and chronic back pain is rising in prevalence in the industrialized Western societies lately. 1 Disability with physical and cognitive consequences of the back pain usually leads to long-lasting treatment span, along with the cost of lost productivity, resulting in a substantial societal cost. Deterioration of the intervertebral disk quality with decrease in disc hydration and height reduction with eventual disk bulging, which further affects spatial relationship of the surrounding anatomic structures

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Sati Akbaba, Jan Tobias Oelmann-Avendano, Tilman Bostel, Harald Rief, Nils Henrik Nicolay, Juergen Debus, Katja Lindel and Robert Foerster

.0 Emotional functioning  Reference 1309 83.2 19.3 0.001  Patients 31 65.1 26.7 Cognitive functioning  Reference 1309 93.4 14.6 < 0.001  Patients 31 73.2 28.4 Social functioning  Reference 1309 93.3 17.1 < 0.001  Patients 31 69.9 29.0 Fatigue  Reference 1309 16.4 21.4 < 0.001  Patients 31 51.6 28.0 Nausea / Vomiting  Reference 1309 2.4 9.6 0.030  Patients 31 11.3 21