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, insufficient antibody response against infections leads to diagnostic problems in these patients. Early diagnosis is important to identify nosocomial transmission and damage to the liver can be prevented by early treatment of acute infection.
Since 1982, we have an effective vaccine for HBV, yet over 350 million people worldwide are estimated to be chronic HBV carriers. The majority of these carriers live in undeveloped or developing countries [ 13 ]. Chronic HBV infection is seen as highly endemic (>8%) in Southeast Asia, Sub-Saharan Africa, Central Asia, and some Eastern
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oocysts were identified in 7.4% and more frequently in children with consistent diarrhea (16.5%), than in those with acute (8.4%) or no (4.0%) diarrhea ( P < 0.001) [ 89 ].
According to the European Centre for Disease Prevention and Control (ECDC), there was an unprecedented increase in cryptosporidiosis in the United Kingdom, The Netherlands, and Germany in late summer/autumn of 2012. In the same year, 2173 cases of cryptosporidiosis were reported in England and Wales, which was 1.5 fold higher than in the previous year and is the greatest since 2003