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Interdisciplinary Toxicology
The Journal of Institute of Experimental Pharmacology of Slovak Academy of Sciences
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Damage of testicular cell macromolecules and reproductive capacity of male rats following co-administration of ethambutol, rifampicin, isoniazid and pyrazinamide

of pyrazinamide in mice. Mutat Res   32 1(1-2): 1-5. Arinaminpathy N, Due C. (2010). Health in financial crises: economic recession and tuberculosis in Central and Eastern Europe. J R Soc Interface 7(52): 1559-1569. Asole A, Panu R, Palmieri G. (1976). Effects of ethambutol on the seminal epitheliun of the rat and chicken. Boll Soc Ital Biol Sper   52 (12): 846-848. Bansal AK, Bilaspuri GS. (2011). Impacts of oxidative stress and antioxidants on semen functions. Vet Med Int   7 : 1

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Glyphosate, pathways to modern diseases II: Celiac sprue and gluten intolerance

-1339. Hardell L, Eriksson M. (1999). A casecontrol study of non-Hodgkin lymphoma and exposure to pesticides. Cancer 85(6): 1353-1360. Hernanz, A, Polanco I. (1991). Plasma precursor amino acids of central nervous system monoamines in children with coeliac disease. Gut 32: 1478-1481. Herrmann W, Obeid R. (2012). Cobalamin defi ciency. Subcell Biochem 56: 301-22. Hershko C, Patz J. (2008). Ironing out the mechanism of anemia in celiac disease. Haematologica 93(12): 1761-1765. Hietanen E, Linnainmaa

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Editorial

Editorial

Communication - Dialogue - Co-operation - Solving problems. These are the words of nowadays Europe. Such approaches should be used in broad spectrum of life as well as in toxicology. It is therefore admirable that EUROTOX commissars, mainly past-president Prof. Liesivuori, invited all heads of European toxicological societies to discuss current issues of toxicology in Europe during IUTOX meeting held in Barcelona in July 2010. Renowned scientists and regulatory officers from Government, Industry and Academia made appearance and talked about contribution of toxicological research to society, importance of communication and education. The strategic meeting was successful. Prof. Liesivuori expressed gratitude to all delegates for the great suggestions and key findings resulting from the brainstorming sessions conducted during the meeting. Majority of delegates agreed that education in toxicology and related fields is the top priority for future. Communication towards society, in the sense of explaining possible risks, should be an important concern as well. Taking a good example from EUROTOX, on the verge of summer the Slovak Toxicology Society SETOX organizes meeting of the toxicological societies from the Central Europe, i.e. Slovak, Czech, Polish, Austrian and Hungarian societies of toxicology. First positive step was done by Visegrad Fund and Federation of European Toxicologists & European Societies of Toxicology, which supported this meeting. It is essential for successful co-operation to establish strong connections, which can be further crucial for meaningful and highly profitable information to society.

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Skeletal fluorosis from the point of view of an occupational exposure to fluorides in former Czechoslovakia

Skeletal fluorosis from the point of view of an occupational exposure to fluorides in former Czechoslovakia

Electrolytic production of aluminium in former Czechoslovakia started in the year 1953 in the Žiar valley in the central Slovakia. However, till 1995 the hygienic conditions for health protection were not met in the factory. It underwent a reconstruction afterwards. The authors demonstrate cases of occupational skeletal fluorosis (currently rare in Europe) in 14 metallurgists which were all disclosed in foundry workers in Žiar nad Hronom as to the year 2005. The occupational disease was diagnosed after 17.7 ± 7.67 years (x ± SD) of exposure in the foundry.

The authors describe the clinical conditions, haematological and biochemical tests (decreased level of ionising calcium was found in serum). The content of fluorides in urine was increased (254.4 ± 130.95 μmol/l). The average age of patients at the time of recognition of the professional etiology of the disease was 57.93 ± 7.95 years. Eight patients were older than 60 years. Skeletal abnormalities were evaluated by using X-ray skiagraphy, estimating the Stage I-III of the skeletal fluorosis. Typically an increase of bone density was found, the compact part of long bones was coarsed, there were calcifications of the interosseous membrane between radius and ulna and some ossifications of the sacrospinal and sacrotuberous ligaments. Twelve patients suffered sensorimotor polyneuropathy of extremities, chronic bronchitis was found in 6 patients (two of them were smokers).

The last occupational case was registered in the year 2001. The authors assume that aluminium production with modern technology of better safety and protection of health of workers is the key which will make the skeletal fluorosis the history in the Czech and Slovak Republic.

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Unrecorded alcohol consumption in Russia: toxic denaturants and disinfectants pose additional risks

. (2007). Comparing alcohol consumption in central and eastern Europe to other European countries. Alcohol Alcohol   42 : 465-473. Pridemore WA, Tomkins S, Eckhardt K, Kiryanov N and Saburova L. (2010). A case-control analysis of socio-economic and marital status differentials in alcohol- and non-alcohol-related mortality among working-age Russian males. Eur J Public Health   20 : 569-575. Razvodovsky Y. (2009). Alcohol poisoning and cardiovascular mortality in Russia 1956-2005. Alcoholism   45 : 27

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Anxiolytic activity of pyridoindole derivatives SMe1EC2 and SMe1M2: behavioral analysis using rat model

, Jansák J. (1999). Evaluation of long-term administration of the antioxidant stobadine on exploratory behavior in rats of both genders. J Appl Toxicol   19 (6): 431-436. Dubovický M, Ujházy E, Kovačovský P, Rychlík I, Kalnovičová T, Navarová J, Turčáni P, Durišová M, Gajdošík A. (1997a). Effect of long-term administration of stobadine on exploratory behaviour and on striatal levels of dopamine and serotonin in rats and their off spring. J Appl Toxicol.   17 : 63-70. European Commission. (2005). Improving the mental

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Plasma and whole brain cholinesterase activities in three wild bird species in Mosul, IRAQ: In vitro inhibition by insecticides

-664. Claudie R, Grolleau G, Chamoulaud S and Riviere J. (2005). Plasma B-esterase activities in European raptors. J Wildlife Dis   41 : 184-208. Clegg DJ and van Gemert M. (1999). Determination of the reference dose for chlorpyrifos: proceedings of an expert panel. J Toxicol Environ Health, Part B   2 : 211-255. Cocker J, Mason HJ, Garfitt SJ and Jones K. (2002). Biological monitoring of exposure to organophosphate pesticides. Toxicol Lett   134 : 97-103. Coggon D. (2002). Work with pesticides

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Chronic social stress increases nitric oxide-dependent vasorelaxation in normotensive rats

, Lemaire V, Ely D, Hendley ED. (1993). Psychosocial stress can induce chronic hypertension in normotensive strains of rats. Hypertension   21 : 714-723. Hu ML, Frankel EN, Leibovitz BE, Tappel AL. (1989). Effect of dietary lipids and vitamin E on in vitro lipid peroxidation in rat liver and kidney homogenates. J Nutr   119 : 1574-1582. Kopp MS, Rethelyi J. (2004). Where psychology meets physiology: chronic stress and premature mortality - the Central-Eastern European health paradox. Brain Res Bull   62 : 351

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Impact of pesticides use in agriculture: their benefits and hazards

Information: Indian Labour Statistics. (1994). Chandigarh: Labour Bureau, Ministry of Labour, 1996. Environews Forum. (1999). Killer environment. Environ Health Perspect   107 : A62 Estok D, Freedman B and Boyle D. (1989). Effects of the herbicides 2,4-D, glyphosate, hexazinone, and triclopyr on the growth of three species of ectomycorrhizal fungi. Bull Environ Contam Toxicol   42 : 835-839. European Commission. (1998). Monitoring of Pesticide Residues in Products of Plant Origin in the European

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