Sanja Ledinski Ficko, Vlatko Pejsa and Vesna Zadnik
on comparable and standardized measures and that can be used to improve the health care system. Conducting studies using various health-related quality of life measures is a basis for improvement of health care delivery. 6 In the last decades, the measurement of health-related quality of life has gained acceptance as a primary or secondary endpoint in cancer research worldwide. 7
Evaluation of quality of life is conducted by using standardized questionnaires. 8 European Organization for Research and Treatment of Cancer (EORTC) has purposed a development of an
as to the lymph node status. 2 , 8 All multigene signatures are recommended for use in HR+HER2- lymph node negative or positive BC by the European Group on Tumor Markers (EGTM), except for BCI. 6 Oncotype DX is the only multigene signature assigned with NCCN category of preference as preferred in lymph node negative patients (category 1 evidence) and is the only signature with predictive value, MammaPrint has category 1 recommendation as prognostic for lymph node negative and positive patients. 9 ASCO guidelines strongly recommend the use of Oncotype DX and
Mojca Jensterle, Soncka Jazbinsek, Roman Bosnjak, Mara Popovic, Lorna Zadravec Zaletel, Tina Vipotnik Vesnaver, Barbara Faganel Kotnik and Primoz Kotnik
) deficiency follow in decreasing order. Central diabetes insipidus resulting from anti-diuretic hormone (ADH) deficiency occurs almost twice more frequently in children than in adults, can be transient after the procedure and it persists in 65–96% of childhood-onset CP subjects. 8 , 18 , 21 Substitution therapy with hr-GH is safe, effective and does not affect relapse and progression rates. 67 In patients with GH substitution, a better QoL has been reported. 11 In children after the surgery, despite their GH deficiency, a normal or accelerated growth pattern has been
Maja Brloznik, Nina Boc, Gregor Sersa, Jan Zmuc, Gorana Gasljevic, Alenka Seliskar, Rok Dezman, Ibrahim Edhemovic, Nina Milevoj, Tanja Plavec, Vladimira Erjavec, Darja Pavlin, Masa Bosnjak, Erik Brecelj, Ursa Lampreht Tratar, Bor Kos, Jani Izlakar, Marina Stukelj, Damijan Miklavcic and Maja Cemazar
irreversible electroporation (IRE) ablation and electrochemotherapy (ECT), are advantageous for patients with unresectable hepatic neoplasia adjacent to major bile ducts and vessels. 1 , 2 , 3 , 5 ECT is a method for the delivery of chemotherapeutic drugs by reversible electroporation, which enables the entry of otherwise poorly or nonpermeant exogenous molecules into cells by the application of short high-intensity electric pulses that induce reversible cell membrane permeabilization. 6 , 7 , 8 ECT is nowadays widely used in European centers for the treatment of
Vincenza Granata, Roberta Fusco, Sergio Venanzio Setola, Elisabetta de Lutio di Castelguidone, Luigi Camera, Salvatore Tafuto, Antonio Avallone, Andrea Belli, Paola Incollingo, Raffaele Palaia, Francesco Izzo and Antonella Petrillo
neuroendocrine tumour and the availability of specialized imaging techniques and expertise. 8
A 45 yrs old female: CEUS study of inhomogeneous pancreatic lesion (A) , with necrotic central area (arrow). CT (B) , during late arterial phase of contrast study shows the same vascular profile (arrow) seeing during CEUS study.
Anatomical and functional imaging
Imaging modalities can be anatomic, which assess the physical characteristics of the tissue, or functional, which assess the biochemical characteristics. 7 The increase of knowledge about these
stereotactic body radiotherapy (SBRT). 3 - 5 SBRT can also be used for inoperable patients, and several studies have also demonstrated that SBRT is as effective for stage I lung cancer as lung resection. 5 , 6 However, SBRT for centrally located lung cancer has been reported to cause more toxicity than for peripheral lung cancer. 7
An increasing number of patients with lung cancer, including those with locally advanced lung cancer, have been treated using proton beam therapy (PBT) with or without chemotherapy. 8 - 12 The advantage of PBT is that it can shape the dose
1. Nichols M, Townsend N, Luengo-Fernandez R, Leal J, Gray A, Scarborough P, Rayner M. European Cardiovascular Disease Statistics 2012. European Heart Network, Brussels: European Society of Cardiology, Sophia Antipolis. 2012.
2. Benedek I, Gyongyosi M, Benedek T. A prospective regional registry of ST-elevation myocardial infarction in Central Romania: impact of the Stent for Life Initiative recommendations on patient outcomes. Am Heart J 2013;166:457-465.
1. Rhudy JP, Bakitas MA, Hyrkäs K, et al. Effectiveness of regionalized systems for stroke and myocardial infarction. Brain Behav. 2015;5:e00398. doi:10.1002/brb3.398.
2. Smith FG, Brogan RA, Alabas O, et al. Comparative care and outcomes for acute coronary syndromes in Central and Eastern European Transitional countries: A review of the literature. Eur Heart J Acute Cardiovasc Care. 2015;4:537-554. doi: 10.1177/2048872614551545.
3. Benedek I, Gyongyosi M, Benedek T. A prospective regional registry of ST-elevation myocardial
Denis Kachanov, Konstantin Dobrenkov, Tatyana Shamanskaya, Ruslan Abdullaev, Evgueniya Inushkina, Rimma Savkova, Svetlana Varfolomeeva and Alexander Rumyantsev
Pastore G, Znaor A, Spreafico F, Graf N, Pritchard-Jones K, Steliarova-Foucher E. Malignant renal tumours incidence and survival in European children (1978-1997): report from the Automated Childhood Cancer Information System project. Eur J Cancer 2006; 42: 2103-14.
Peris-Bonet R, Martinez-Garcia C, Lacour B, Petrovich S, Giner-Ripoll B, Navajas A, et al. Childhood central nervous system tumours - incidence and survival in Europe (1978-1997): report from Automated Childhood Cancer Information System project. Eur J Cancer 2006; 42: 2064-80.