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Zeynep Yildiz, Abdulkadir Koçer, Şahin Avşar and Göksel Cinier

:329-65. 5. Hamm Cw., Bassand Jp., Agewall S., Bax J. Esc Committee For Practice Guidelines. Esc Guidelines For The Management Of Acute Coronary Syndromes In Patients Presenting Without Persistent St-Segment Elevation: The Task Force For The Management Of Acute Coronary Syndromes (Acs) In Patients Presenting Without Persistent St-Segment Elevation Of The European Society Of Cardiology (Esc). Eur Heart J. 2011; 32:2999-3054. 6. Kerr G., Ray G., Wu O., Stott Dj., Langhorne P. Elevated Troponin After Stroke: A Systematic Review. Cerebrovasc Dis. 2009; 28

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Anca Bălănescu, Paul Bălănescu, Valentina Comănici, Iustina Stan, Beata Acs, Laura Prisăcariu, Florin Brezan, Tatiana Ciomârtan and Ioan Gherghina

Abstract

Background and aims. The aim of this study is to assess the lipid profile pattern of pediatric overweight and/or obese patients with Non-Alcoholic Fatty Liver Disease (NAFLD) in relation to IDF Consensus Criteria for Metabolic Syndrome (MetS).

Material and Methods. We conducted a cross-sectional preliminary study on 45 consecutive pediatric patients. Overweight or obese children aged from 3 to 18 years were included. Standardized measurement of blood pressure and anthropometric parameters were performed. Biological evaluation included inflammatory status, lipid profile, glycemic profile, full blood count and liver function tests. Abdominal ultrasound was performed in all patients.

Results. Prevalence of MetS was 44.4%. A number of 21 patients (46.7%) had NAFLD. MetS patients had higher risk for NAFLD (OR = 9.5, 95% CI = 2.42-37.24). Also patients with positive familial history of type 2 diabetes had a 6.61 fold higher risk for NAFLD (OR = 6.61, 95% CI = 1.74-25.1). We performed a subgroup analysis in patients under ten years old. Patients under the age of ten which had both NAFLD and MetS met more frequently the hypertriglyceride criterion. After adjusting for age and MetS presence, triglyceride levels independently associated with NAFLD (adjusted R square = 0.46, unstandardized B coefficient = 34.51, 95% CI = 4.01-65.02, p = 0.02).

Conclusion. NAFLD obese patients had higher prevalence of MetS, higher BMI and particular lipid profile pattern. Triglyceride levels independently associated with NAFLD after adjusting for age and MetS presence. According to our findings we suggest early triglyceride testing (even below the age of ten) in selected patients.