Introduction Acute coronary syndrome (ACS) encompasses unstable angina (UA), non-ST-segment elevation myocardial infarction (NSTEMI), and ST-segment elevation myocardial infarction (STE-MI). UA and NSTE-MI are classified as non-ST-segment elevation acute coronary syndrome (NSTE-ACS). Life-threatening NSTE-ACS is a leading cause of emergency and hospitalization in the United States. [ 1 ] It causes a lot of public expenditures. Its cost might account for a large proportion of worldwide health care expenditures in the future. [ 2 ] The basic medicine for
Xiao-huan Gong, Jin-ming Yu, Yong Mao and Da-yi Hu
Mehmet Can Ugur, Ferhat Ekinci, Utku Erdem Soyaltın and Harun Akar
Introduction. Contrast-induced nephropathy (CIN) is associated with increased morbidity and mortality after percutaneous coronary intervention (PCI). On the other hand, CIN is a serious complication in patients with diabetes or renal impairment undergoing percutaneous coronary intervention (PCI). CIN after PCI may be associated with prolonged hospitalization, increased rates of kidney injury, and short- and long-term mortality. Factors that have been associated with CIN include: diabetes mellitus, congestive heart failure, recent acute myfocardial infarction, cardiogenic shock, and pre-existing renal impairment. In this study, we investigated contrast nephropathy development after coronary angiography (CAG) in patients presenting with acute coronary syndrome, who were hospitalized initially in the Coronary Care Unit and subsequenttly referred to the Internal Medicine Clinic in a tertiary care hospital.
Methods. We’ve analyzed 335 patients’ records retrospectively in 1 year that were followed-up with acute coronary syndrome (ACS) in the Coronary Care Unit (CCU) and transferred to the Internal Medicine Clinic (IMC). The following parameters were evaluated: age, gender, chronic disease and drug history, biochemical values evaluated before hospitalization to CCU, ejection fraction (EF) and left atrium diameter (LA), with or without previous CAG; values of serum creatinine (sCr) levels before CAG and after 48 hours. Values of p <0.05 were considered to be significant.
Results. 126 of 335 patients were female and 209 were male. The average age of patients was 64.2 years. 122 patients used angiotensin converting enzyme inhibitor (ACEI), 54 patients used furosemide. CIN development rate of CAG patients was 22.8% (n=54). There was no significant relationship with age, gender and chronic disease history in CIN patients. When laboratory findings were compared, there was no significant relationship except for potassium value before CAG. However, potassium values were significantly higher in CIN patients (p=0.001). When drug usage of patients was compared, 48.1% (n=26) of CIN patients used ACEI and there was a significant relationship between ACEI use and CIN development (p=0.026).
Conclusions. CIN development rate was 22.8% and it was relatively high when compared with literature data. Awareness about contrast nephropathy develepment risk and assessment of risk factors before the procedure should be increased in our Center.
Justin S. Michael, Bong-Seop Lee, Miqin Zhang and John S. Yu
T, Wang HQ, Pantoja JL, Yoon CW, Hanson CJ, et al . Reactive oxygen species responsive nanoprodrug to treat intracranial glioblastoma. ACS Nano 2013;7:3061-77. 10.1021/nn400347j Lee BS Amano T Wang HQ Pantoja JL Yoon CW Hanson CJ et al Reactive oxygen species responsive nanoprodrug to treat intracranial glioblastoma ACS Nano 2013 7 3061 – 77 41 Parsons DW, Jones S, Zhang X, Lin JC, Leary RJ, Angenendt P, et al . An integrated genomic analysis of human glioblastoma multiforme. Science 2008;321:1807-12. 10.1126/science.1164382 Parsons DW
Konstantinos V. Voudris and Mladen I. Vidovich
the impact of practicing “defensive medicine” is considered, the economic costs are even higher both for the health system as well as for medical services consumers who face increased medical care costs. [ 18 ] In this setting, TRA has emerged as a reliable alternative to the traditional femoral approach. TRA has been shown to reduce mortality both in ST-segment elevation myocardial infarction [ 19 ] and non-ST-segment elevation acute coronary syndrome (NSTE ACS) [ 20 ] . Equally important, in patients with acute coronary syndromes, TRA and TRA PCI have been
Hongting Wang, Zuan-tao Lin, Yulin Yuan and Tianfu Wu
-14. 10.1021/acs.jproteome.5b00905 Wu T Ding H Han J Arriens C Wei C Han W et al. Antibody-Array-Based Proteomic Screening of Serum Markers in Systemic Lupus Erythematosus: A Discovery Study J Proteome Res 2016 15 2102 14 41 Wu T, Xie C, Wang HW, Zhou XJ, Schwartz N, Calixto S, et al . Elevated urinary VCAM-1, P-selectin, soluble TNF receptor-1, and CXC chemokine ligand 16 in multiple murine lupus strains and human lupus nephritis. J Immunol 2007; 179: 7166-75. 10.4049/jimmunol.179.10.7166 Wu T Xie C Wang HW Zhou XJ Schwartz N Calixto S et al. Elevated urinary VCAM-1