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Rasha Hamdy Hamed

randomized controlled trial is warranted; however, the indolent nature of thyroid cancer and the high costs of conducting such study have made this difficult in the past. Conclusion This representative study addresses the survival benefit of RAI for patients with intermediate-risk PTC, but conducting of large prospective randomized controlled trial is still warranted. References [1] American Cancer Society. ‘Cancer facts, figures2013. http://www.cancer.org/acs/groups/content/@epidemiologysurveilance/documents/document/acspc-036845.pdf Accessed’ November

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Anna F. Delgado, Markus Fahlström, Markus Nilsson, Shala G. Berntsson, Maria Zetterling, Sylwia Libard, Irina Alafuzoff, Danielle van Westen, Jimmy Lätt, Anja Smits and Elna-Marie Larsson

Introduction Gliomas are neoplasms arising from neuroglial or precursor cells. Neuropathological classification is based on dominant cell type, malignancy grade atypia (I–IV), cell density, mitosis, endothelial proliferation, necrosis and genetic tumor properties. 1 , 2 Astrocytomas (ACs) and oligodendrogliomas (ODs) are the most prevalent histological glioma subtypes. Neuropathologically glioma grade II differs from grade III primarily based on cell density and proliferation and may present with similar imaging patterns on morphological Magnetic resonance

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Nina Trost, Peter Juvan, Gregor Sersa and Natasa Debeljak

. Oncogene 2003; 22 : 7265-79. Acs G, Acs P, Beckwith SM, Pitts RL, Clements E, Wong K, et al. Erythropoietin and erythropoietin receptor expression in human cancer. Cancer Res 2001; 61 : 3561-5. Cui X, Schiff R, Arpino G, Osborne CK, Lee AV. Biology of progesterone receptor loss in breast cancer and its implications for endocrine therapy. J Clin Oncol 2005; 23 : 7721-35. Larsson AM, Jirstrom K, Fredlund E, Nilsson S, Ryden L, Landberg G, et al. Erythropoietin receptor expression and

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Andrej Vranic

-50. Yang SY, Park CK, Park SH, Kim DG, Chung YS, Jung HW. Atypical and anaplastic meningiomas: prognostic implications of clinicopathological features. J Neurol Neurosurg Psychiatry 2008; 79: 574-80. Nordqvist ACS, Smurawa H, Mathiesen T. Expression of matrix metalloproteinases 2 and 9 in meningiomas associated with different degrees of brain invasiveness and edema. J Neurosurg 2001; 95: 839-84. Strojnik A. Search of the shortest regimen: fractionation of a fully isoeffective combination of hyperfractionated and

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Nina Trost, Tina Stepisnik, Sabina Berne, Anja Pucer, Toni Petan, Radovan Komel and Natasa Debeljak

renal carcinoma cells. Kidney Int 2000; 58: 647-57. 8. Kumar SM, Acs G, Fang D, Herlyn M, Elder DE, Xu XW. Functional erythropoietin autocrine loop in melanoma. Am J Pathol 2005; 166: 823-30. 9. Selzer E, Wacheck V, Kodym R, Schlagbauer-Wadl H, Schlegel W, Pehamberger H, et al. Erythropoietin receptor expression in human melanoma cells. Melanoma Res 2000; 10: 421-6. 10. Ludwig H. rHuEPO and treatment outcomes: the preclinical experience. Oncologist 2004; 9 (Suppl 5): 48-54. 11. Nakamura Y

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Branka Strazisar and Nikola Besic

. Anesth Analg 1998; 86: 86-9. 16. Liu SS, Kehlet H. Clinical approach to the patient with postoperative pain. ACS surgery: principles and practice . Hamilton: BC Decker Inc.; 2009. 17. Kay B. A clinical investigation of piritramide in the treatment of postoperative pain. Brit J Anesth 1971; 43: 1167-71. 18. Chernik DA, Gillings D, Laine H, Hendler J, Silver JM, Davidson AB, et al. Validity and Reliability of the Observer’s Assessment of Alertness/Sedation Scale: study with intravenous midazolam. J Clin

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Tomaz Makovec

with a unique mode of action. Bioconjugate Chem 2016; 27: 2132-48. 10.1021/acs.bioconjchem.6b00353 Huang X Huang R Gou S Wang Z Liao Z Wang H Combretastatin A-4 analogue: a dual-targeting and tubulin inhibitor containing antitumor Pt(IV) moiety with a unique mode of action Bioconjugate Chem 2016 27 2132 48 10.1021/acs.bioconjchem.6b00353 68 Ishikawa T, Ali-Osman F. Glutathione-associated cis-diamminedichloro-platinum(II) metabolism and ATP-dependent efflux from leukaemia cells. Molecular characterization of glutathione

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Matej Skocaj, Metka Filipic, Jana Petkovic and Sasa Novak

microscopic techniques. Environ Sci Technol 2006; 40 : 4353-9. Kocbek P, Teskac K, Kreft ME, Kristl J. Toxicological aspects of long-term treatment of keratinocytes with ZnO and TiO2 nanoparticles. Small 2010; 6 : 1908-17. Xia T, Kovochich M, Liong M, Madler L, Gilbert B, Shi HB, et al. Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties. Acs Nano 2008; 2 : 2121-34. Donaldson K, Stone V, Clouter A

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Simona Kranjc, Maja Cemazar, Gregor Sersa, Janez Scancar and Sabina Grabner

and hydroxymethylpyridine Eur J Med Chem 2010 45 134 41 10.1016/j.ejmech.2009.09.035 15 Coluccia M, Natile G. Trans-platinum complexes in cancer therapy. Anticancer Agents Med Chem 2007; 7 : 111-23. 10.2174/187152007779314080 Coluccia M Natile G. Trans-platinum complexes in cancer therapy Anticancer Agents Med Chem 2007 7 111 23 16 Johnstone TC, Suntharalingam K, Lippard SJ. The next generation of platinum drugs: targeted Pt (II) agents, nanoparticle delivery, and Pt (IV) prodrugs. Chem Rev 2016; 116 : 3436-86. 10.1021/acs

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Milos Vittori, Barbara Breznik, Tajda Gredar, Katja Hrovat, Lilijana Bizjak Mali and Tamara T Lah

regulatory and functional linkages: application to cell proliferation and invasion networks in glioblastoma. J Proteome Res 2015; 14 : 5017-27 10.1021/acs.jproteome.5b00765 Gupta MK Jayaram S Reddy DN Polisetty RV Sirdeshmukh R. Transcriptomic and proteomic data integration and two-dimensional molecular maps with regulatory and functional linkages: application to cell proliferation and invasion networks in glioblastoma J Proteome Res 2015 14 5017 27 4 Klekner Á, Hutóczki G, Virga J, Reményi-Puskár J, Tóth J, Scholtz B, et al. Expression pattern of invasion