Search Results

1 - 10 of 77 items :

  • Clinical Medicine x
Clear All
Increase in albumin by daclatasvir/asunaprevir therapy is correlated with decrease in aspartate transaminase

. All the patients ( n = 125) SVR patients ( n = 108) non-SVR patients ( n = 11) P -Value (SVR patients vs . non-SVR patients Group A ( n = 64) Group B ( n = 28) Group C ( n = 16) P -Value (A vs . B) P -Value (A vs . C) P -Value (B vs . C) Gender (male : female) 55 : 70 48 : 60 3 : 8 NS 28:36:00 9:19 11:05 NS NS 0.019 Age (years) 68.1 ± 9.4 67.6 ± 8.9 70.7 ± 10.8 NS 65.9 ± 9.4 68.3 ± 7.5 72.8 ± 6.8 NS 0.0081 NS History of past IFN-based therapy (none : relapse : breakthrough

Open access
The relation of anthropometric measurements and insulin resistance in patients with polycystic kidney disease

.26 ± 45.26 121.09 ± 27.95 b Student’s t -test; 0.001 ** **P < 0.01. HOMA-IR (μU/mmol) 2.89 ± 1.88 (2.58) 2.59 ± 1.84 (1.97) a Mann-Whitney U test; 0.209 HbA1c(%) 5.53 ± 0.39 5.49 ± 0.40 b Student’s t -test; 0.627 Glucose (mg/dL) 95.93 ± 10.41 93.93 ± 9.43 b Student’s t -test; 0.246 Urea (mg/dL) 42.79 ± 25.05 (33.55) 27.49 ± 8.19 (26.20) a Mann-Whitney U test; 0.001 ** **P < 0.01. Creatinine (mg/dL) 1.23 ± 0.95 (0.93) 0.73 ± 0.15 (0.72) a Mann-Whitney U test; 0.001 ** **P < 0.01. Uric acid (mg

Open access
Does hepatic impairment influence renal function parameters in liver cirrhosis?

level cystatin C was an independent predictor of mortality and development of HRS-1.[ 8 ] Serum β 2 microglobulin is another renal function parameter that correlates with glomerular filtration rate. A study showed that serum β 2 microglobulin concentration was significantly increased in patients with liver cirrhosis (especially non-alcoholic cirrhosis).[ 9 ] Serum β 2 microglobulin level was elevated in HCV-related chronic liver disease, and may also be used as a marker for progression towards liver cirrhosis and hepatocellular carcinoma.[ 10 ] Herein, we

Open access
Exploring patient characteristics and barriers to Hepatitis C treatment in patients on opioid substitution treatment attending a community based fibro-scanning clinic

.0 (43.7, 90.0) 0.251 Alcohol /drug unstable (self-declared) % ( n ) 70.5 (48) 70.0 (35) 72.2 (13) 0.913 Values are median (25 th –75 th percentile) or % ( n ). Continuous variables assessed by independent T -test; Categorical variables assessed by Chi-square analysis. MMT: methadone maintenance treatment. P <0.05 were considered statistically significant. On an average, the study population was diagnosed with Hepatitis C for 10.5 years, with just less than half (47%) describing having symptoms related to HCV infection. Over half

Open access
Favorable outcome in a patient with systemic BCGitis after intra-bladder instillation of Calmette-Guerin Bacillus highlighting the importance of making the correct diagnosis in this rare form of sepsis

to the intensive care unit (ICU) and amoxicillin-clavulanic acid was initiated. Blood testing highlighted an inflammatory syndrome [C-reactive protein (CRP) between 70 and 90 mg/L, < 10] and hepatic cytolysis and cholestasis evoking liver involvement. Sediment and urinary cultures were negative. Blood cultures for mycobacteria were done after nightly fever peaks. Empirical anti-tuberculous treatment was started associating isoniazid, rifampicin and vitamin B6 in the event of a BCGitis. Chest X-Ray ( Figure 1 ) showed an interstitial syndrome. Figure 1 Chest X

Open access
NPS2390, a selective calcium-sensing receptor antagonist controls the phenotypic modulation of hypoxic human pulmonary arterial smooth muscle cells by regulating autophagy

. HPASMCs cells were cultured in SMCM in complete medium (89% DMEM + 10% fetal calf Serum + 1% growth factor), and 100 U/mL was added to the medium Cyan-streptomycin. The cells were placed at 37°C, 21% O 2 , 5% CO 2 , 74% subculture in N 2 , incubator under saturated humidity, take within 6 generations counting cells in experiments. Hypoxia treatment of HPASMCs The original medium of HPASMCs was discarded and 1% fetal bovine serum was added to DMEM. The culture was incubated for 12 h for synchronization and then changed to SMCM culture. The cells were placed in a

Open access
Hepatitis C virus exposure rate among health-care workers in rural Lower Egypt governorates

challenges. Am J Infect Control 2006; 34: 193-200. 10.1016/j.ajic.2005.05.028 Talaat M Kandeel A Rasslan O Hajjeh R Hallaj Z El-Sayed N Mahoney FJ. Evolution of infection control in Egypt: achievements and challenges Am J Infect Control 2006 34 193 200 15 Miller FD, Elzalabany MS, Hassani S, Cuadros DF. Epidemiology of hepatitis C virus exposure in Egypt: Opportunities for prevention and evaluation. World J Hepatol 2015; 7: 2849-58. 10.4254/wjh.v7.i28.2849 Miller FD Elzalabany MS Hassani S Cuadros DF. Epidemiology of hepatitis C virus exposure in Egypt

Open access
A single-step multiplex quantitative real time polymerase chain reaction assay for hepatitis C virus genotypes

and serotyping J Virol Methods 1997 65 9 17 11 Nguyen MH, Keeffe EB. Prevalence and treatment of hepatitis C virus genotypes 4, 5, and 6. Clin Gastro Hep 2005; 3: S97–101. 10.1016/S1542-3565(05)00711-1 Nguyen MH Keeffe EB. Prevalence and treatment of hepatitis C virus genotypes 4, 5, and 6 Clin Gastro Hep 2005 3 S97 101 12 Cai Q, Zhao Z, Liu Y, Shao X, Gao Z. Comparison of three different HCV genotyping methods: core, NS5B sequence analysis and line probe assay. Int J Mol Med 2013; 31: 347-52. 10.3892/ijmm.2012.1209 Cai Q Zhao Z Liu Y

Open access
Hepatitis C in Cameroon: What is the progress from 2001 to 2016?

[ 10 ] , 1.3% in Douala [ 11 ] , to 3.2–4.8% in Yaoundé [ 12 , 13 ] . In addition, several cases of coinfection with HIV and HBV were reported [ 11 , 14 , 15 ] . Health Care Workers Health care workers (HCW) represent an important risk group in HCV transmission. However, HCV infection in this population was poorly studied in Cameroon. Regular screening is therefore necessary to avoid patient’s contamination. Birguel et al . evaluated the viral markers of hepatitis C in 93 HCW in the Sahelian district of Tokombere (Far North Cameroon). About 6.3% were HCV

Open access
Metabolic acidosis status and mortality in patients on the end stage of renal disease

(mmHg) 96.5 ± 12.5 100.25 ± 13.5 98.7 ± 9.6 c-f PWV (m/s) 12.3 ± 1.6 10.9 ± 1.5 * p < 0.05. 9.3 ± 1.04 * p < 0.05. AIx (%) 25.2 ± 2.1 23.7 ± 1.98 * p < 0.05. 22.4 ± 1.3 * p < 0.05. PP (mmHg ) 60.45 ± 21.3 57.9 ± 19.01 51.1 ± 10.2 Hemoglobin (g/dL) 11.8 ± 1.58 11.7 ± 0.96 12.5 ± 1.5 FRS (%) 13.5 ± 9.6 11.2 ± 9.05 6.4 ± 7.6 * p < 0.05. BMI: body mass index, nPCR: normalized protein catabolic rate, SBC: serum bicarbonate concentrations, HDL: high density lipoproteins, LDL: low density

Open access