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A hypothetical approach on gender differences in cancer diagnosis

health belief model to explore why women decide for or against the removal of their ovaries to reduce their risk of developing cancer BMC Womens Health 2018 18 184 4 Pardoll D. Cancer and the immune system: Basic concepts and targets for intervention. Semin Oncol 2015; 42: 523–38. 10.1053/j.seminoncol.2015.05.003 26320058 Pardoll D Cancer and the immune system: Basic concepts and targets for intervention Semin Oncol 2015 42 523 38 5 Klein G. Toward a genetics of cancer resistance. Proc. Natl Acad Sci U S A 2009; 106: 859–63. 10.1073/pnas

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Endoscopic Ultrasound-guided Gastroenterostomy: A Promising Alternative to Surgery

. Endoscopic therapy with lumen-apposing metal stents is safe and effective for patients with pancreatic walled-off necrosis. Clin Gastroenterol Hepatol 2016;14:1797–803. 27189914 10.1016/j.cgh.2016.05.011 Sharaiha RZ Tyberg A Khashab MA Kumta NA Karia K Nieto J et al Endoscopic therapy with lumen-apposing metal stents is safe and effective for patients with pancreatic walled-off necrosis Clin Gastroenterol Hepatol 2016 14 1797 803 33 Siddiqui AA, Adler DG, Nieto J, Shah JN, Binmoeller KF, Kane S, et al. EUS-guided drainage of

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Effect of weight reduction on histological activity and fibrosis of lean nonalcoholic steatohepatitis patient

were screened subsequently according to the inclusion and exclusion criteria. Patients with history of alcohol consumption (≥ 20 g/day in men or ≥ 10 g/day in women), positive viral makers (hepatitis B, hepatitis C), or known case of secondary fatty liver ( e.g ., use of systemic drugs including anabolic steroids, tamoxifen, anticonvulsant, antiarrhythmic drugs, etc .), chronic liver disease (CLD) with known etiology, pregnant women or suffering from any kind of malignancies before baseline were excluded. Moreover, patients with known contraindications to liver

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Treatment of ventilator-associated pneumonia with high-dose colistin under continuous veno-venous hemofiltration

DC, Camus C, Bauer TT, et al. Attributable mortality of ventilator-associated pneumonia: a meta-analysis of individual patient data from randomised prevention studies. Lancet Infect Dis 2013; 13: 665-71. 10.1016/S1473-3099(13)70081-1 23622939 Melsen WG Rovers MM Groenwold RH Bergmans DC Camus C Bauer TT et al Attributable mortality of ventilator-associated pneumonia: a meta-analysis of individual patient data from randomised prevention studies Lancet Infect Dis 2013 13 665 71 2 Bercault N, Boulain T. Mortality rate

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Increase in albumin by daclatasvir/asunaprevir therapy is correlated with decrease in aspartate transaminase

. All the patients ( n = 125) SVR patients ( n = 108) non-SVR patients ( n = 11) P -Value (SVR patients vs . non-SVR patients Group A ( n = 64) Group B ( n = 28) Group C ( n = 16) P -Value (A vs . B) P -Value (A vs . C) P -Value (B vs . C) Gender (male : female) 55 : 70 48 : 60 3 : 8 NS 28:36:00 9:19 11:05 NS NS 0.019 Age (years) 68.1 ± 9.4 67.6 ± 8.9 70.7 ± 10.8 NS 65.9 ± 9.4 68.3 ± 7.5 72.8 ± 6.8 NS 0.0081 NS History of past IFN-based therapy (none : relapse : breakthrough

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The relation of anthropometric measurements and insulin resistance in patients with polycystic kidney disease

.26 ± 45.26 121.09 ± 27.95 b Student’s t -test; 0.001 ** **P < 0.01. HOMA-IR (μU/mmol) 2.89 ± 1.88 (2.58) 2.59 ± 1.84 (1.97) a Mann-Whitney U test; 0.209 HbA1c(%) 5.53 ± 0.39 5.49 ± 0.40 b Student’s t -test; 0.627 Glucose (mg/dL) 95.93 ± 10.41 93.93 ± 9.43 b Student’s t -test; 0.246 Urea (mg/dL) 42.79 ± 25.05 (33.55) 27.49 ± 8.19 (26.20) a Mann-Whitney U test; 0.001 ** **P < 0.01. Creatinine (mg/dL) 1.23 ± 0.95 (0.93) 0.73 ± 0.15 (0.72) a Mann-Whitney U test; 0.001 ** **P < 0.01. Uric acid (mg

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Does hepatic impairment influence renal function parameters in liver cirrhosis?

level cystatin C was an independent predictor of mortality and development of HRS-1.[ 8 ] Serum β 2 microglobulin is another renal function parameter that correlates with glomerular filtration rate. A study showed that serum β 2 microglobulin concentration was significantly increased in patients with liver cirrhosis (especially non-alcoholic cirrhosis).[ 9 ] Serum β 2 microglobulin level was elevated in HCV-related chronic liver disease, and may also be used as a marker for progression towards liver cirrhosis and hepatocellular carcinoma.[ 10 ] Herein, we

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Exploring patient characteristics and barriers to Hepatitis C treatment in patients on opioid substitution treatment attending a community based fibro-scanning clinic

.0 (43.7, 90.0) 0.251 Alcohol /drug unstable (self-declared) % ( n ) 70.5 (48) 70.0 (35) 72.2 (13) 0.913 Values are median (25 th –75 th percentile) or % ( n ). Continuous variables assessed by independent T -test; Categorical variables assessed by Chi-square analysis. MMT: methadone maintenance treatment. P <0.05 were considered statistically significant. On an average, the study population was diagnosed with Hepatitis C for 10.5 years, with just less than half (47%) describing having symptoms related to HCV infection. Over half

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Favorable outcome in a patient with systemic BCGitis after intra-bladder instillation of Calmette-Guerin Bacillus highlighting the importance of making the correct diagnosis in this rare form of sepsis

to the intensive care unit (ICU) and amoxicillin-clavulanic acid was initiated. Blood testing highlighted an inflammatory syndrome [C-reactive protein (CRP) between 70 and 90 mg/L, < 10] and hepatic cytolysis and cholestasis evoking liver involvement. Sediment and urinary cultures were negative. Blood cultures for mycobacteria were done after nightly fever peaks. Empirical anti-tuberculous treatment was started associating isoniazid, rifampicin and vitamin B6 in the event of a BCGitis. Chest X-Ray ( Figure 1 ) showed an interstitial syndrome. Figure 1 Chest X

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NPS2390, a selective calcium-sensing receptor antagonist controls the phenotypic modulation of hypoxic human pulmonary arterial smooth muscle cells by regulating autophagy

. HPASMCs cells were cultured in SMCM in complete medium (89% DMEM + 10% fetal calf Serum + 1% growth factor), and 100 U/mL was added to the medium Cyan-streptomycin. The cells were placed at 37°C, 21% O 2 , 5% CO 2 , 74% subculture in N 2 , incubator under saturated humidity, take within 6 generations counting cells in experiments. Hypoxia treatment of HPASMCs The original medium of HPASMCs was discarded and 1% fetal bovine serum was added to DMEM. The culture was incubated for 12 h for synchronization and then changed to SMCM culture. The cells were placed in a

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