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Quantification of ascorbic acid and sodium ascorbate in powder blends for tableting and in vitamin C chewable tablets by NIR-chemometry

Abstract

The paper proposes a near infrared method able to directly and simultaneously quantify ascorbic acid and sodium ascorbate in powder blends for tableting and in vitamin C chewable tablets without any sample preparation. In the first step, calibration models for the quantification of ascorbic acid and sodium ascorbate in powder blends for tableting and subsequently in chewable vitamin C tablets (corresponding to 80-120 % active substance) were developed according to an experimental design with 2 variables and 5 levels. Then, using the best calibration models, the methods were fully validated in terms of recovery, precision and accuracy for both powder blends and vitamin C chewable tablets. The validated concentration range was 15.14-18.51 % for ascorbic acid and 12.06-14.49 % for sodium ascorbate in powder blends and 91.85-111.03 mg per tablet for ascorbic acid and 71.01-84.50 mg per tablet for sodium ascorbate in tablets. Validation results showed good precision and accuracy.

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Antioxidant supplementation and serum lipids in patients with Graves' disease: Effect on LDL-cholesterol

-8981(96)06415-7. A. Seven, E. Taşan, F. Inci, H. Hatemi and G. Burçak, Biochemical evaluation of oxidative stress in propylthiouracil treated hyperthyroid patients. Effects of vitamin C supplementation, Clin. Chem. Lab. Med.   6 (1998) 767-770; DOI: 10.1515/CCLM.1998.136. V. B. Vrca, F. Skreb, I. Cepelak, Z. Romic and Lj. Mayer, Supplementation with antioxidants in the treatment of Graves' disease; the effect on glutathione peroxidase activity and concentration of selenium, Clin. Chim. Acta   341 (2004) 55-63; DOI: 10.1016/j.cccn.2003

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Antithrombotic activity of flavonoids and polyphenols rich plant species

. J. Health Syst. Pharm. 65 (2008) 1134–1143; https://doi.org/10.2146/ajhp060662 6. A. Algra and J. van Gijn, Is clopidogrel superior to aspirin in secondary prevention of vascular disease? Curr. Control Trials Cardiovasc. Med. 1 (2000) 143–145; https://doi.org/10.1186/cvm-1-3-143 7. A. Grzybowski and K. Pietrzak, Albert Szent-Györgyi (1893-1986): the scientist who discovered vitamin C, Clin. Dermatol. 31 (2013) 327–331; https://doi.org/10.1016/j.clindermatol.2012.08.001 8. B. Havsteen, Flavonoids, a class of natural products of high

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eNOS Promoter Activation by Red Wine Polyphenols: an Interaction Study

endothelial nitric oxide synthase by apigenin. Life Sci. 2010;87:743–749. [7] Chou TC. Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Pharmacol Rev. 2006; 58:621–681. [8] Edgell CJ, McDonald CC, Graham JB. Permanent cell line expressing human factor VIII-related antigen established by hybridization. Proc Natl Acad Sci USA. 1983;80:3734–3737. [9] Han D, Yi OS, Shin HK. Solubilization of vitamin C in fish oil and

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The efficacy of newly synthesised agent and natural antioxidant treatment in diabetic and hypertensive rats

References HAMDEN, K. - BOUJBIHA, M. A. - MASMOUDI, H. - AYADI, F. M. - JAMOUSSI, K. - ELFEKI, A. Combined vitamins (C and E) and insulin improve oxidative stress and pancreatic and hepatic injury in alloxan diabetic rats. Biomed Pharmacother. 63, 2009, p. 95-109. INOGUCHI, T. - SONTA, T. - TSUBOUCHI, H. - ETOH, T. - KAKIMOTO, M. - SONODA, N. a kol. Protein kinase C-dependent increase in reactive oxygen species (ROS) production in vascular tissues of diabetes role of vascular NAD(P)H oxidase. J Am Nephrol

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Nitrones: not only extraordinary spin traps, but also good nitric oxide sources in vivo

for cardioprotection, Heart Fail. Rev. 12 (2007) 217-234; DOI: 10.1007/s10741-007-9026-1. 7. R . Rodrigo, J. C. Prieto and R. Castillo, Cardioprotection against ischaemia/reperfusion by vitamins C and E plus n-3 fatty acids: molecular mechanisms and potential clinical applications, Clin. Sci. (Lond). 124 (2013) 1-15; DOI : 10.1042/CS20110663. 8. R . Rodrigo, J. Vinay, R. Castillo, M. Cereceda, R. Asenjo and J. Zamorano, Use of vitamins C and E as a prophylactic therapy to prevent postoperative atrial fibrillation, Int. J. Cardiol. 138

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Development of Novel Formulations to Enhance in Vivo Transdermal Permeation of Tocopherol

influence of colloidal silica on skin deposition of vitamins C and E simultaneously incorporated in topical microemulsions, Drug Dev. Ind. Pharm. 36 (2010) 852-860; DOI: 10.3109/03639040903541187. 26. A. Nada, Y. S. R. Krishnaiah, A. Zaghloul and I. Khattab, Analysis of vitamin E in commercial cosmetic preparations by HPLC, J. Cosmet. Sci. 61 (2010) 353-365; PMID 20939975. 27. K. Zhao and J. Singh, In vitro percutaneous absorption enhancement of propranolol hydrochloride through porcine epidermis by terpenes/ethanol, J. Control. Release 62

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The Evaluation of Efficacy of Pycnogenol® Fractions on Endothelial Dysfunction

. Combined vitamins (C and E) and insulin improve oxidative stress and pancreatic and hepatic injury in alloxan diabetic rats. Biomed Pharmacother. 2009;63(2):95-9. [16] Hlavačková L et al. The Effect of Indapamide on Development of Myocardial Hypertrophy and Fibrosis in L-NAME-Induced Hypertension in Rat. Physiol. Res. 2011;60:845-852. [17] Jankyova S et al. Glucose and blood pressure lowering effects of Pycnogenol® are inefficient to prevent prolongation of QT interval in experimental diabetic cardiomyopathy. Pathol

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Anticholinesterase and antioxidant activities of foliar extract from a tropical species: Psidium guajava L. (Myrtaceae) grown in Algeria

;76(4):899-905. 21. Apak R, Güçlü K, Ozyürek M, Karademir SE. Novel total antioxidant capacity index for dietary polyphenols and vitamins C and E, using their cupric ion reducing capability in the presence of neocuproine: CUPRAC method. J Agric Food Chem . 2004;52 (26):7970-81. 22. Marco GJ. A rapid method for evaluation of antioxidants. J Am Oil Chem Soc . 1968;45, 594-8. 23. Ellman GL, Courtney D, Andies V, Featherstone RM. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol . 1961;7, 88-95. 24. Xiaoyong S, Luming C

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In vitro propagated Mentha rotundifolia (L.) Huds and antioxidant activity of its essential oil

Wiss Technol . 1995;28:25-30. 9. Barkat M, Laib I. Chemical composition and antioxidant activity of the essential oil of dry flowers of Lavandula officinalis . Ind Eng J. 2011;6:46-54. 10. Re R, Pellegrini N, Proteggente A, Pannala A, Yang M, Rice-Evans C. Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radic Bio Med . 1999;26:1231-7. 11. Apak R, Güçlü K, Özyürek M, Karademir SE. Novel total antioxidant capacity index for dietary polyphenols and vitamins C and E, using their cupric ion reducing capability

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