3. Rahimi R, Nikfar S, Larijani B, Abdollahi M. A review on the role of antioxidants in the management of diabetes and its complication. Biomed Pharmacother 59: 365-373, 2005.
4. Dakhale GN, Cahudhari HV, Shrivastava M. Supplementation of vitaminC reduces blood glucose and improves Glycosylated haemoglobin in type 2 diabetes mellitus: A randomized, double blind study. Advances in Pharmacological Sciences Article ID 195271: 1-5, 2011.
5. Bhatt JK, Thomas S, Nanjan MJ. Effect of oral supplementation of
Patrick M. Honore, David De Bels, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani and Herbert D. Spapen
To the editor
Pharmacokinetic and dose-response data suggest a vitaminC (vit C) dose largely exceeding 3 g daily in critically ill patients. We recently proposed higher vit C dosing in cardiac arrest patients who require continuous renal replacement therapy (CRRT).[ 1 ] In a reaction, Spoelstra-de Man et al . rebutted that increasing the vit C dose above 2 g/day during continuous veno-venous hemofiltration (CVVH) was unnecessary when normal plasma vit C concentrations are targeted. They based their standpoint on calculating less vit C removal during CVVH
1. Laires MJ, Monteiro CP, Bicho M . Role of cellular magnesium in health and human disease. Front Biosci 9: 262-276, 2004.
2. Houston DK, Johnson MA . Does vitaminC intake protect against lead toxicity? Nutr Rev 58(3 Pt 1): 73-75, 2000.
3. Van der Velden U, Kuzmanova D, Chapple IL . Micronutritional approaches to periodontal therapy. J Clin Periodontol 38: 142-158, 2011.
4. Pendyala G, Thomas B, Kumari S. The challenge of antioxidants to free radicals in periodontitis. J Indian Soc Periodontol 12: 79-83, 2008
syndrome without an established genetic background. It is well known that malignant neoplasms occur in some families more often than it would be expected by chance and reasons for this phenomenon have mostly remained unknown.
In addition, it is possible that findings about suppressive activities of vitaminC in carcinogenesis might mainly reflect the restrictive effects of this natural compound on the activity and expression of MMPs, thereby suppressing invasion, migration and metastasis, as it is well known that vitaminC is a strong inhibitor for both MMP-2 and MMP-9
Background and Aims To document the nutritional content of food intake in overweight and obese people, in order to change dietary habits for acquiring the normal weight. Material and methods We assessed the nutritional content of food intake (kilocalories, vitamins and minerals) in a sample of 124 overweight and obese people and 33 subjects with normal weight. We also measured abdominal circumference, percent of body fat and resting metabolic rate. Results Overweight and obese patients, compared to normal weight, have a significant increased intake of vitamin A (p=0.002), vitamin B1 (p=0.037), vitamin B5 (p=0.047), vitamin C (p=0.029) and vitamin D (p=0.015), sodium (p=0.036), iron (p=0.032) and selenium (p=0.007). The percent of body fat in obese persons is increased (p=0.00001) and very close to abnormal in patients with no weight problems. An increased food intake, above the calculated resting metabolic rate, is associated with a slower metabolism and a rapid resting metabolic rate is often associated with food intake below resting metabolic rate (p=0.002). Conclusions All subjects had imbalanced intake of vitamins and minerals. The normal weight group didn’t achieve the dietary recommendations for vitamins and minerals and we found that these subjects had risk factors for cardiac diseases like increased abdominal circumference, body fat and sodium intake.
Nasr-Eddine Kebir, Ahmed Aichouni and Touria Zahzeh
functional foods, Nutraceuticals, and food supplements in intestinal health. Nutrients 2: 611–625, 2010.
18. Althnaian T, Albokhadaim I, El-Bahr SM . Biochemical and histopathological study in rats intoxicated with carbontetrachloride and treated with camel milk. Springerplus 2: 57, 2013.
19. Konuspayeva G, Faye B, Loiseau G. Variability of vitaminC content in camel milk from Kazakhstan. Journal of Camelid Science: 4: 63–69, 2011.
20. Elagamy EI, Ruppanner R, Ismail A, Champagne CP, Assaf R. Purification and characterization of lactoferrin
, Shimojo N, Suzuki Y et al. Maternal intake of Natto, a Japan's traditional fermented soybean food, during pregnancy and the risk of eczema in Japanese babies. Allergol Int 63: 261-266, 2014.
30. Wijaya-Erhardt M, Muslimatun S, Erhardt JG . Fermented soyabean and vitaminC-rich fruit: a possibility to circumvent the further decrease of iron status among iron deficient pregnant women in Indonesia. Public Health Nutr 14: 2185-2196, 2011.
-implantation embryos through cell death effector pathways. Nature Med 4(12): 1421-1424, 1998.
7. Chi MM, Pingsterhouse J, Carayannopoulos M, Moley KH. Decrease glucose transporter expression triggers Bax-dependent apoptosis in the murine blatocysts. J Biol Chem 275(51): 40252-40257, 2000.
8. Zaken V, Kohen R, Ornoy A. VitaminsC and E improve rat embryonic antioxidant defense mechanism in diabetic culture medium. Teratology 64(1): 33-44, 2001.
9. Jauniaux E, Hempstock J, Greenwold N. Trophoblastic oxidative stress in relation to
histochemistry and ultrastructure of microglial response to monosodium glutamate-mediated neurotoxicity in the arcuate nucleus. Histol histopathol 14: 165-174, 1999.
29. Hashem HE, El-Din Safwat MD, Algaidi S. The effect of monosodium glutamate on the cerebellar cortex of male albino rats and the protective role of vitaminC (histological and immunohistochemical study). J Molec Histol 43: 179-186, 2012.
30. Andulla B, Varadacharyulu NCh. Antioxidant role of mulberry leaves in streptozotocin-diabetic rats. Clin Chim Acta 338: 3-10, 2003.
31. Divi SM
Compared with other types of tea, green tea is unfermented and contains the highest concentration of catechins, in which EGCG accounts for as much as 50% of its total polyphenols and has been reported to possess antioxidative, antiinflammatory, and anticarcinogenic effects [6, 16] . EGCG is estimated to be 25 times more potent than vitamin E and 100 times more potent than vitaminC [ 17 ] .
The kidney is essential in blood filtration, excretion of waste products, regulating the balance of electrolytes, along with maintaining homeostatic conditions, and thus at high