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The beneficial effect of long-term supplementation of vitamin C on renal mitochondrial disturbances in streptozotocin-induced diabetic rats

-7. 6. de Cavanagh EMV, Ferder L, Toblli JE, Piotrkowski B, Stella I, Fraga CG, et al. Renal mitochondrial impairment is attenuated by AT1 blockade in experimental Type I diabetes. Am J Physiol Heart Circ Physiol 2008; 294: H456-65. 7. Przedborski S, Jackson-Lewis V, Fahn S. Antiparkinsonian therapies and brain mitochondrial complex I activity. Mov Disord. 1995; 10:312-7. 8. Rosa EF, Ribeiro RF, Pereira FMT, Freym­ller E, Aboulafia J, Nouailhetas VLAS. Vitamin C and E supplementation prevents mitochondrial damage of ileum myocytes

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Vitamin C pretreatment protects from nickel-induced acute nephrotoxicity in mice

. BiochemPharmacol 1999;58:1501-10. doi: 10.1016/S0006-2952(99)00232-4 13. Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 2007;39:44-84. doi: 10.1016/j.biocel.2006.07.001 14. Ariharan VN, Kalirajan K, Meena Devi VN, Prasad NP. An exotic fruit which forms the new natural source for vitamin-C. Rasayan J Chem 2012;5:356-9. 15. Cathcart RF. Vitamin C: the nontoxic, nonrate-limited, antioxidant free radical

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Protective effects of quercetin and vitamin C against nicotine-induced toxicity in the blood of Wistar rats

toxicity, oxidative damage, histological changes and haematotoxicity in male rats: the protective effects of green tea extract. Exp Toxicol Pathol 2015;67:253-9. doi: 10.1016/j.etp.2015.01.001. 4. Ahmed MA, Hassan KH, Hassanein KM, Waly H. Role of vitamin C and selenium in attenuation of nicotine induced oxidative stress, P53 and Bcl2 expression in adult rat spleen. Pathophysiology 2014;21:211-7. doi: 10.1016/j. pathophys.2014.07.003. 5. Li Y, Yu C, Shen G, Li G, Shen J, Xu Y, Gong J. Sirt3- MnSOD axis represses nicotine

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In Vivo Protective Effects of Gallic Acid Isolated from Peltiphyllum Peltatum Against Sodium Fluoride-Induced Oxidative Stress in Rat Erythrocytes

Abstract

Gallic acid has been identified as an antioxidant component of the edible and medicinal plant Peltiphyllum peltatum. The present study examined its potential protective role against sodium fluoride (NaF)-induced oxidative stress in rat erythrocytes. Oxidative stress was induced by NaF administration through drinking water (1030.675 mg m-3 for one week). Gallic acid at 10 mg kg-1 and 20 mg kg-1 and vitamin C for positive controls (10 mg kg-1) were administered daily intraperitoneally for one week prior to NaF administration. Thiobarbituric acid reactive substances, antioxidant enzyme activities (superoxide dismutase and catalase), and the level of reduced glutathione were evaluated in rat erythrocytes. Lipid peroxidation in NaF-exposed rats significantly increased (by 88.8 %) when compared to the control group (p<0.05). Pre-treatment with gallic acid suppressed lipid peroxidation in erythrocytes in a dose-dependent manner. Catalase and superoxide dismutase enzyme activities and glutathione levels were reduced by NaF intoxication by 54.4 %, 63.69 %, and 42 % (p<0.001; vs. untreated control group), respectively. Pre-treatment with gallic acid or vitamin C significantly attenuated the deleterious effects. Gallic acid isolated from Peltiphyllum peltatum and vitamin C mitigated the NaF-induced oxidative stress in rat erythrocytes.

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Antihaemolytic activity of thirty herbal extracts in mouse red blood cells

Abstract

Reactive oxygen species (ROS) can lead to haemolysis and eventually to diseases such as thalassemia and sickle cell anaemia. Their action can be counteracted by the antihaemolytic activity of therapeutic agents. The aim of our study was to identify plants that most efficiently counteract ROS-caused haemolysis. From ten plants known for their antioxidant activity (Orobanche orientalis G. Beck, Cucumis melo L., Albizzia julibrissin Durazz, Galium verum L., Scutellaria tournefortii Benth, Crocus caspius Fischer & Meyer, Sambucus ebulus L., Danae racemosa L., Rubus fruticsos L., and Artemisia absinthium L.) we prepared 30 extracts using three extraction methods (percolation, Soxhlet, and ultrasound-assisted extraction) to see whether the extraction method affects antihaemolytic efficiency, and one extraction method (polyphenol extraction) to see how much of this action is phenol-related. Extract antihaemolytic activity was determined in mice red blood cells and compared to that of vitamin C as a known antioxidant. Nine of our extracts were more potent than vitamin C, of which G. verum (aerial parts/percolation) and S. tournefortii (aerial parts/polyphenol) extracts were the most potent, with an IC50 of 1.32 and 2.08 μg mL-1, respectively. Haemolysis inhibition depended on extract concentration and the method of extraction. These plants could provide accessible sources of natural antioxidants to the pharmaceutical industry

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Liver Aspartate Transaminase Isoenzymes as Biomarkers of Chronic Exposure to Chromium(VI)

, Rosen C, Crawford GC, Wergedal J, Baylink Dj. Spontaneous fractures in the mouse mutant sfx are caused by deletion of the gulonolactone oxidase gene, causing vitamin C defi ciency. J Bone Miner Res 2005;20:1597-610. doi: 10.1359/JBMR.050406 19. Hemmati AA, Nazari Z, Ranjbari N, Torfi A. Comparison of the preventive effect of vitamin C and E on hexavalent chromium induced pulmonary fibrosis in rat. Inflammopharmacology 2008;16:195-7. doi: 10.1007/ s10787-008-7004-4 20. Wang XF, Lou XM, Shen Y, Xing mL, Xu LH. Apoptoticrelated protein

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Antioxidants in Organophosphorus Compounds Poisoning

dimethoate in female adult rats. Ecotoxicol Environ Saf 2011;74:811-9. 40. Dwivedia N, Flora SJS. Concomitant exposure to arsenic and organophosphates on tissue oxidative stress in rats. Food Chem Toxicol 2011;49:1152-9. 41. Dirican EK, Kalender Y. Dichlorvos-induced testicular toxicity in male rats and the protective role of vitamins C and E. Exp Toxicol Pathol 2012;64:821-30. 42. Ojha A, Yaduvanshi SK, Pant SC, Lomash V, Srivastava N. Evaluation of DNA damage and cytotoxicity induced by three commonly used organophosphate

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Protective Effects of Selenium, Calcium, and Magnesium Against Arsenic-Induced Oxidative Stress in Male Rats

, Kaushik P, Flora SJS. Co-administration of α-lipoic acid and vitamin C protects liver and brain oxidative stress in mice exposed to arsenic contaminated water. Water Quality Environ Health 2009;1:135-44. Berlin A, Schaller KH. European standardized method for the determination of delta-aminolevulinic acid dehydratase activity in blood. Z Klin Chem Klin Biochem 1974;12:389-90. Jollow DJ, Mitchell JR, Zamppaglione Z, Gillette JR. Bromobenzene induced liver necrosis. Protective role of glutathione and evidence for 3

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Redox imbalance caused by pesticides: a review of OPENTOX-related research

. Durak D, Uzun FG, Kalender S, Ogutcu A, Uzunhisarcikli M, Kalender Y. Malathion-induced oxidative stress in human erythrocytes and the protective effect of vitamins C and E in vitro . Environ Toxicol 2009;24:235-42. doi: 10.1002/tox.20423 33. Al-Sarar AS, Abobakr Y, Bayoumi AE, Hussein HI. Cytotoxic and genotoxic effects of abamectin, chlorfenapyr, and imidacloprid on CHO K1 cells. Environ Sci Pollut R 2015;22:17041-52. doi: 10.1007/s11356-015-4927-3 34. Bal R, Türk G, Tuzcu M, Yilmaz O, Kuloglu T, Gundogdu R, Gür S, Agca A, Ulas M, Cambay Z, Tuzcu Z

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Prostate-Specific Antigen (PSA) in Serum in Relation to Blood Lead Concentration and Alcohol Consumption in Men

. Lancet 2000;356:233-41. Brooks JD, Metter EJ, Chan DW, Sokoll LJ, Landis P, Nelson WG, Muller D, Andres R, Carter HB. Plasma selenium level before diagnosis and the risk of prostate cancer development. J Urol 2001;166:2034-8. Hoenjet KM, Dagnelie PC, Delaere KP, Wijckmans NE, Zambon JV, Oosterhof GO. Effect of a nutritional supplement containing vitamin E, selenium, vitamin C and coenzyme Q10 on serum PSA in patients with hormonally untreated carcinoma of the prostate: a randomised placebo-controlled study. Eur

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