Nataša Ristić, Vladimir Ajdžanović, Dragana Petrović-Kosanović, Marko Miler, Gordana Ušćebrka and Verica Milošević
, I. (2004). Polymorphisms in androgen and estrogen receptor genes: effects on male aging. Exp Gerontol. 39, 603-611. https://doi.org/10.1016/j.exger.2004.06.017 PMid:15582276
5. Wang, X.J., Stocco, D.M. (2005). The decline in testosterone biosynthesis during male aging: A consequence of multiple alterations. Mol Cell Endocrinol. 238, 1-7. https://doi.org/10.1016/j.mce.2005.04.009 PMid:15939533
6. Bonavera, J.J., Swerdloff, R.S., Leung, A., Lue, Y.H., Baravarian, S., Superlano, L., Sinha-Hikim, A.P., Wang, C. (1997). In the male brown-Norway (BN
Barbara Woźniak, Iwona Matraszek-Żuchowska, Sebastian Witek and Andrzej Posyniak
1. Angeletti R., Contiero L., Gallina G., Montesissa C.: The urinary ratio of testosterone to epitetosterone: a good marker of illegal treatment also in cattle? Vet Res Comm 2006, 30, 127–131.
2. Antignac J.P., De Wasch K., Monteau F., De Brabander H., Andre F., Le Bizec B.: The ion suppression phenomenon in liquid chromatography–mass spectrometry and its consequences in the field of residue analysis. Anal Chim Acta 2005, 529, 129–136.
3. ARO SOP 475B, Method validation using ResVal®. Validation according to EC/2002/657. National
Barbara Woźniak, Sebastian Witek, Iwona Matraszek-Żuchowska, Alicja Kłopot and Andrzej Posyniak
1. Angeletti R., Contiero L., Gallina G., Montesissa C.: The urinary ratio of testosterone to epitetosterone: a good marker of illegal treatment also in cattle? Vet Res Comm 2006, 30, 127-131.
2. Chen Y., Yazdanpanah M., Hoffman B.R., Diamandis E.P., Wong P-Y.: Rapid determination of serum testosterone by liquid chromatography-isotope dilution tandem mass spectrometry and a split sample comparison with three automated immunoassays. Clin Biochem 2009, 42, 484-490.
3. Council Directive 88/146/EEC. 1988
Boric acid administration has a detrimental effect on reproductive organs, livers, and kidneys in rats. In the present study, male Wistar rats were orally fed with boric acid at a dose regimen of 350 mg/kg bodyweight for a period of 30 days, followed by oral administration of hydroalcoholic extract of Eclipta alba at a dose regimen of 500 mg/kg body weight orally for 60 days. The boric acid treated group showed signs of toxicity, such as liver damage, nephropathy, and complete damage to the testis, as early as 15 days which became aggravated by 30 days of the boric acid study period. Oxidative stress in all of the vital organs showed a significant increase. Following the plant extract treatment, complete reversal in reproductive toxicity was observed. The hormonal levels viz., testosterone, estrogen, and FSH returned to normal ranges after the 60 days of plant extract treatment. Significant reversal comparable to the control groups was observed in oxidative stress in the vital tissues. The fertility of the rats was found to be restored. The altered tissue morphology showed significant signs or recovery as observed under light microscopic examination. Thus, overall recovery was observed in the boric acid treated rats which received treatment with the plant extract. It can be concluded that Boric acid definitely has detrimental effects on the male reproductive system and the plant extract showed promising results. However, the mode of action and the active components for the same needs to be further investigated.
Radosław Kujawski, Joanna Bartkowiak-Wieczorek, Anna Bogacz, Monika Karasiewicz, Przemysław Ł. Mikołajczak, Bogusław Czerny and Przemysław M. Mrozikiewicz
The aim of this study was to investigate the influence of standardized crude aqueous Epilobium angustifolium L. extract [100 mg/kg/day, p.o.] on the expression level of SRC kinase mRNA - a representatives of non-genomics xenobiotics signaling pathway in prostate ventral lobes of testosterone-induced, castrated rats. We have shown that in all analyzed groups induced by testosterone an elevation of SRC kinase mRNA transcription was observed, in comparison to control animals (not receiving the testosterone), (p<0.05). Finasteride in rats induced by testosterone caused the strongest inhibition of SRC mRNA transcription (p<0.05). In rats receiving testosterone and the plant extract a ca. 90% decrease of mRNA level was observed vs. testosterone-induced animals (p<0.05), while in testosterone-induced animals receiving concomitantly E. angustifolium extract and finasteride the observed reduction reached 87.3% (p<0.05).
We did not observed, however, any positive feedback between studied plant extract and finasteride in the inhibitory activity (p<0.05). Further experimental studies should be performed in order to the understanding the molecular basis of interactions, the efficacy and safety of tested plant extract.
Nóra Boross, Gábor Markó, Miklós Laczi, László Zsolt Garamszegi, Gergely Hegyi, Márton Herényi, Dorottya Kiss, Gergely Nagy, Balázs Rosivall, Eszter Szöllősi and János Török
Boiesmenu, C., Gauthier, G. & Larochelle, J. 1992.Phisiology of prolonged fasting in Greater Snow Geese (Chen caerulescens atlantica). - Auk 109: 501-521.
Carpenter, F. L. 1975. Bird hematocrits: effect of high altitude and strength of flight. - Comparative Biochemistry and Physiology 12: 415-417. doi: 10.1016/0300-9629(75)90035-3
Cecil, H. C. & Bakst, M. R. 1991. Correlations of organ weights, hematocrit and testosterone with sexual maturity of the male Turkey. - Poultry Science 70: 1252-1257. doi
Gábor Markó, Manuel Azcárate, Gergely Hegyi, Gábor Herceg, Miklós Laczi, Gergely Nagy, Juan Carlos Señar, János Török and László Zsolt Garamszegi
, P. J., Hurley, L. L., Fokidis, H. B., Lerbour, B., Silverin, B., Silverin, B., Sabo, J. & Sharp, P. J. 2010. Acute stress rapidly decreases plasma testosterone in a free-ranging male songbird: Potential site of action and mechanism. - General and Comparative Endocrinology 169: 82-90. doi: 10.1016/j.ygcen.2010.07.009
Eilam, D. 2005. Die hard: A blend of freezing and fleeing as a dynamic defense - implications for the control of defensive behavior. - Neuroscience and Biobehavioral Reviews 29: 1181-1191. doi: 10.1016/j.neubiorev.2005
Atefe Maghsoudlou, Alireza Sadeghi Mahoonak, Hossein Mohebodini and Fidel Toldra
Royal jelly (RJ) has been known for centuries, but in the last 5-6 decades its systematic production and consumption has increased. RJ is secreted by the hypopharyngeal and mandibular glands of worker honeybees (Apis mellifera). This thick and milky substance contains water, proteins, carbohydrates, lipids, minerals, vitamins and such bio-active compounds as acetylcholine, peptides, the hormones testosterone, progesterone, prolactin, estradiol, (hydroxydecanoic acid) (HAD), adenosine monophosphate (AMP)-N1Oxide, polyphenols, flavonoids and adenosine. Because of its bioactive compounds, RJ can be considered as a functional and nutraceutical food. The main goal of this review is to summarize and update its physicochemical properties, bio-active ingredients, storage stability and shelf life. The functional properties are antioxidative activity, insulin-like action, improvement against diabetes, liver protection, antitumoral action, neurotrophic action, antibiotic effect, anti-inflammatory action and wound healing, hypotensive effect and blood regulatory actions, anti-aging effect and skin protection, effects on the reproductive system and fertility and also fortifying, tonic action and immunomodulating and anti-alergic activity. RJ may cause allergic reactions, asthma and even fatal anaphylaxis in some humans. Therefore, RJ should be orally ingested as nutreaceutical agent or food-ingredient only after an allergy test.
Iwona Matraszek-Żuchowska, Barbara Woźniak, Katarzyna Sielska and Andrzej Posyniak
testosterone propionate), Deca-Durabolin (with nandrolone decanoate), Durabolin (with nandrolone phenylpropionate), Boldane, Equipoise, Parenabol, and Vebonol (all with boldenone undecylenate), as well as a wide range of other products.
The hormones present in animal tissues may be of endogeneous origin or may have been illegally administered. The concentration of hormones occurring naturally in living organisms differs from animal to animal depending on the species, sex, age, normality of physiological and individual development, and the state of health and acquired
Abdolmajid Valipour, Behrooz Heidari, Mahvash Hadavi and Ayub Yousefi
tilapias - J. Fish Biol. 37: 249-255.
Nash J.P., Davail-Cuisset B., Bhattacharyya S., Suter H.C., Le Menn F., Kime D.E. 2000 - An enzyme linked immunosorbant assay (ELISA) for testosterone, estradiol, and 17,20â-dihydroxy-4-pregenen-3-one using acetylcholinesterase as tracer: application to measurement of diel patterns in rainbow trout (Oncorhynchus mykiss) - Fish Physiol. Biochem. 22: 355-363.
Olsen Y.A., Press C.Mc.L. 1997 - Degradation kinetics of immunoglobulin in the egg, alevin and fry of Atlantic salmon, Salmo salar L, and the