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disability, diabetes mellitus, diabetes insipidus and psychosis itself. Only Long et al. (2015) attempted to explore the alternative causes of new incontinence. Clozapine associated nocturnal enuresis should only be considered once the mentioned have been excluded. – The diagnostic tool was used to determine the presence of nocturnal enuresis. Those studies that relied solely on patient recall had less power than those that used a validated questionnaire during the interview setting. – The temporal relationship between clozapine initiation and the timing of NE

temporality, and the use of self-administered questionnaires may introduce recall bias. Use of questionnaire can add recall bias in measurement of mental health indicators. Important variables such as use of pharmacological or psychological treatments among the respondents were not known, which can add bias in the study. Acknowledgements None. Ethical approval Ethical approval for this study was received from Ethical Review Board of CMH Lahore Medical College & Institute of Dentistry, Lahore Cantt, Pakistan. Informed consent Written informed consent was obtained from all

usually found at low concentrations in energy drinks and is thought to enhance the stimulating properties of caffeine. Studies made on guarana show that the herb improves decision-making performance ( Pomportes et al., 2014 ), temporal performance ( Pomportes et al., 2017 ), task performance ( Kennedy et al., 2004 ), working memory and attentional processing ( Scholey et al., 2013 ). Promising effects in some cognitive domains were found by Haskell et al. (2007) , Kennedy et al. (2004) , Scholey et al. (2013) and Nehlig (2010) . We decided to perform this