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Interdisciplinary Toxicology
The Journal of Institute of Experimental Pharmacology of Slovak Academy of Sciences
Open access
Novel pentacyclic triterpene isolated from seeds of Euryale Ferox Salisb. ameliorates diabetes in streptozotocin induced diabetic rats

streptozotocin induced diabetic rats. Springer Plus. 4 : 1059–67. Ahmed D, Sharma M, Kumar V, Bajaj HK, Verma A. (2015 b ). 2β-hydroxybetulinic acid 3β-caprylate: an active principle from Euryale ferox salisb. seeds with antidiabetic, antioxidant, pancreas & hepatoprotective potential in streptozotocin induced diabetic rats. Journal of Food Science and Technology . 52 : 5427–5441. Ahmed D, Khan MI, Kaithwas G, Roy S, Gautam S, Singh M, Devi U, Yadav, R, Rawat J, Saraf S. (2017). Molecular docking Analysis and Antidiabetic activity of Rifabutin against STZ

Open access
Insights on the relationship between structure vs. toxicological activity of antibacterial rhodamine-labelled 3-hydroxy-4-pyridinone iron(III) chelators in HepG2 cells

Mycobacterium avium infection. J Inorg Biochem 121 : 156–166. Moniz T, Silva D, Silva T, Salomé Gomes M, Rangel M. (2015). Antimycobacterial activity of rhodamine 3,4-HPO iron chelators against Mycobacterium avium: analysis of the contribution of functional groups and of chelator's combination with ethambutol. MedChemComm 6 : 2194–2203. Moreira AC. (2013). Phytoestrogens as Alternative to the Hormone Replacement Therapy: Mitochondrial and Cellular Interactions. PhD thesis in Bio-Sciences, Faculty of Sciences and Technology, University of Coimbra. Nunes

Open access
Alteration in MDA, GSH level and hematological changes due to thiamine deficiency in Mus musculus

-yielding dairy cows. Czech Journal of Animal Science-UZPI 47 (8): 309–318. Kronfeld DS, Medway W. (1969). In A textbook of veterinary clinical pathology. Edited by W. Medway, J. E. Prier, and J. S. Wilkinson. The Williams and Wilkins Co., Baltimore. Lakshmanan SA, Rajendran CS. (2013). Impact of Dichlorvos on tissue glycogen and protein content in freshwater fingerlings, Oreochromismossambicus (Peters). International Journal of Research in Environmental Science and Technology 3 (1): 19–25. Liu D, Ke Z, Luo J. (2017). Thiamine deficiency and

Open access
Review Article. Technical aspects of oxygen level regulation in primary cell cultures: A review

Abstract

Oxygen (O2) is an essential element for aerobic respiration. Atmospheric concentration of O2 is approximately 21%. Mammalian cells, however, are generally adapted to O2 levels much lower than atmospheric conditions. The pericellular levels of O2 must also be maintained within a fairly narrow range to meet the demands of cells. This applies equally to cells in vivo and cells in primary cultures. There has been growing interest in the performance of cell culture experiments under various O2 levels to study molecular and cellular responses. To this end, a range of technologies (e.g. gas-permeable technology) and instruments (e.g. gas-tight boxes and gas-controlled incubators) have been developed. It should be noted, however, that some of these have limitations and they are still undergoing refinement. Nevertheless, better results should be possible when technical concerns are taken into account. This paper aims to review various aspects of O2 level adjustment in primary cell cultures, regulation of pericellular O2 gradients and possible effects of the cell culture medium.

Open access
Skeletal fluorosis from the point of view of an occupational exposure to fluorides in former Czechoslovakia

Skeletal fluorosis from the point of view of an occupational exposure to fluorides in former Czechoslovakia

Electrolytic production of aluminium in former Czechoslovakia started in the year 1953 in the Žiar valley in the central Slovakia. However, till 1995 the hygienic conditions for health protection were not met in the factory. It underwent a reconstruction afterwards. The authors demonstrate cases of occupational skeletal fluorosis (currently rare in Europe) in 14 metallurgists which were all disclosed in foundry workers in Žiar nad Hronom as to the year 2005. The occupational disease was diagnosed after 17.7 ± 7.67 years (x ± SD) of exposure in the foundry.

The authors describe the clinical conditions, haematological and biochemical tests (decreased level of ionising calcium was found in serum). The content of fluorides in urine was increased (254.4 ± 130.95 μmol/l). The average age of patients at the time of recognition of the professional etiology of the disease was 57.93 ± 7.95 years. Eight patients were older than 60 years. Skeletal abnormalities were evaluated by using X-ray skiagraphy, estimating the Stage I-III of the skeletal fluorosis. Typically an increase of bone density was found, the compact part of long bones was coarsed, there were calcifications of the interosseous membrane between radius and ulna and some ossifications of the sacrospinal and sacrotuberous ligaments. Twelve patients suffered sensorimotor polyneuropathy of extremities, chronic bronchitis was found in 6 patients (two of them were smokers).

The last occupational case was registered in the year 2001. The authors assume that aluminium production with modern technology of better safety and protection of health of workers is the key which will make the skeletal fluorosis the history in the Czech and Slovak Republic.

Open access
Toxicity of perfluorinated carboxylic acids for aquatic organisms

-5836. Herzke D, Schlabach M, Mariussen E, Uggerud H, Heimstad E. (2007). A literature survey on selected chemical compounds. TA-2238/2007. http://www.sft.no/publikasjoner/2238/ta2238.pdf Broxterman HJ, Georgopapadakou NH. (2005). Anticancer Therapeutics: "Addictive" multi-targeted drugs, new drug combinations. Drug Resistance Updates   8 : 183-197. Houde M, Martin JW, Letcher RJ, Solomon KR, Muir DCG. (2006). Biological monitoring of polyfluoroalkyl substances: A review. Environmental Science & Technology   40 : 3463

Open access
Cholinesterase based amperometric biosensors for assay of anticholinergic compounds

: 795-798. Pohanka M, Kuca K, and Kassa J. (2008a). New performance of biosensor technology for Alzheimer's disease drugs: in vitro comparison of tacrine and 7-methoxytacrine. Neuroendocrinol Lett   29 : 755-758. Pohanka M, Musilek K, and Kuca K. (2009a). Progress of biosensors based on cholinesterase inhibition. Curr Med Chem   16 : 1790-1798. Pohanka M, Dobes P, Drtinova L, and Kuca K. (2009b). Nerve agents assay using cholinesterase based biosensor. Electroanalysis DOI: 10.1002/elan

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Toluene abuse markers in marginalized populations

, Gecková AM, Halánová M, HepaMeta Team. (2014). Higher Prevalence of Nephropathy in Young Roma Females Compared with Non-Roma Females. Cent Eur J Public Health. S2014 : S28–S31. Važan P, Khan MR, Poduška O, Stastná L, Miovský M. (2011). Chronic toluene misuse among Roma youth in Eastern Slovakia. Subst Use Misuse 46 : 57–61. Yacob AR, Zinalibdin MR. (2010). High Performance Liquid Chromatography Determination of Urinary Hippuric Acid and Benzoic Acid as Indices for Glue Sniffer urine. World Academy of Science Engineering and Technology International

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Original Article. Toxicity of Glandularia selloi (Spreng.) Tronc. leave extract by MTT and neutral red assays: influence of the test medium procedure

C, Duez P. (2014). Methods applied to the in vitro primary toxicology testing of natural products: State of the art, strengths, and limits. Planta Med [Epub in print] Butler M. (2004). Animal cell culture and technology. 2a Ed. London, England: Taylor & Francis. Česen MH, Pegan K, Spes A, Turk B. (2012). Lysosomal pathways to cell death and their therapeutic applications. Exp Cell Res, 318, 1245-51. Fotakis G, Timbrell JA. (2006). In vitro cytotoxicity assays: comparison of LDH, neutral red, MTT and protein assay in

Open access