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, autoregulation is lost in severe head injury or acute ischemic stroke, leaving surviving brain tissue unprotected against the potentially harmful effect of blood pressure changes. Likewise, autoregulation may be lost in the surroundings of a space-occupying brain lesion, be it a tumor or a hematoma [ 70 ]. Below and above this limit or in pathological cases, CBF passively follows systemic arterial pressure. Beyond the lower limit of autoregulation, vessels passively collapse, and ischemia results. Beyond the upper limit of autoregulation or the “breakthrough zone”, increased