Guntis Gerhards, Elīna Pētersone-Gordina and Zita Krūmiņa
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Imanta Ozola-Zālīte, Anda Vīksna, Jeļena Ivanova, Agnese Ūdre and Aldis Puķītis
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Tālis Kauliñš, Natālija Proñina, Henrik Rüffert, Markus Wehner, Māris Mihelsons, Oksana Osipova and Aleksejs Miščuks
Identification of A Novel Mutation in RYR1 Gene in Malignant Hyperthermia-Like Patient's Family Members
Malignant hyperthermia (MH) is a rare pharmacogenetic disorder with an autosomal dominant inheritance that presents as a hypermetabolic response in skeletal muscle to volatile anaesthetic (halothane, isoflurane, desflurane, sevoflurane) and the depolarising muscle relaxant succinil-choline and rarely to stresses such as vigorous exercise and heat. We investigated the relatives of an individual with suspected MH and found a novel mutation in RYR1 gene. The molecular analysis of RYR1 gene revealed a novel nucleotide substitution in exon 6 - G528T (Glu-176-Asp) in four family members of the patient. The in vitro contracture test (IVCT) according to the European Malignant Hyperthermia Group (EMHG) guidelines showed a MH susceptible phenotype in two tested family members.
Maija Dzintare, Larisa Baumane, Dainuvīte Meirena, Jeļena Šaripova, Lāsma Ļauberte, Ivars Kalviņš and Nikolajs Sjakste
Modifications of nitric oxide production in rat tissues by ellagic acid, ipriflavone and resveratrol: a comparative study
When administered as drugs or consumed as food components, polyphenolic compounds synthesised in plants interfere with intracellular signal transduction pathways, including pathways of nitric oxide (NO) synthase (NOS) expression. However, the effects of these compounds in vivo do not always correlate with NOS-inhibiting activities, as revealed in experiments with cultured cells. The goal of this work was to compare the effects of resveratrol, ellagic acid and ipriflavone on NO production in rat organs measured by means of ESR spectroscopy. All of the above compounds are known as inhibitors of iNOS expression. The presumed ability to decrease NO production was manifested only by ellagic acid; it decreased NO production in spleen of intact rats. Iproflavone and resveratrol even enhanced the lipopolyssacharides (LPS)-induced increase of NO production. Ipriflavone increased NO production in the brain cortex, cerebellum, liver, heart, kidneys, blood, lungs and skeletal muscles. Resveratrol produced a similar effect in all of the above organs, except kidneys, lungs and muscles. Taken together, our results suggest that modifications of NO level in tissues by a natural compound cannot be predicted from data about its effects on NOS expression or activity. This stresses the importance of direct measurements of NO in tissues.
Ženija Roja, Valdis Kaļķis, Henrijs Kaļķis and Ilmārs Pencis
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Normunds Legzdiņš, Danute Labeikytė and Nikolajs Sjakste
Electrophoretic pattern of the polypeptide component in the tight DNA-protein complexes in rat and chicken tissues and its partial characterisation in rat liver
Tightly bound to DNA proteins (TBP) are a protein group that remain attached to DNA with covalent or non-covalent bonds after its deproteinisation. The distribution of TBP in genes reflects the type of cell differentiation. It has been hypothesised that TBP binding is involved in regulation of gene expression. Early studies reported uniformity of the TBPs from different sources. Later it was shown that TBPs obtained from DNA, isolated in mild conditions from evolutionary distant species, are different. Application of chloroform DNA extraction without use of externally added enzymes enabled us to reveal differences in the TBP spectrum in plant organs and changes of this spectrum in the course of plant development. The goal of this work was to study the electrophoretic pattern of the polypeptide component in the tight DNA-protein complexes in organs of animals: a mammal (rat) and a bird (chicken). Rat thymus TBPs were represented by 70 and 60 kDa proteins, and the same polypeptides were observed also in brain and skeletal muscles. Kidney TBPs were represented by 85, 70, 65, 60 and 37 kDa polypeptides; 85, 77, 70, 60, 50 and 37 kDa TBPs were characteristic of liver. Numerous minor peptides were observed in all samples studied. The spectrum of chicken liver and blood TBPs differed in distribution of proteins of 25-35 kDa. Mass-spectrometry of 14 bands from rat liver TBP gel revealed 43 different proteins. Chromatin modifying proteins and repair enzymes, transcription factors, serpins, ATPase, kinases and enzymes of ubiquitin-proteasome pathway were found among the TBPs. Thus, TBPs appear to be a vast protein group involved in several intranuclear processes. It is hypothesised that numerous functions ascribed to the nuclear matrix are performed in the TBP complexes.
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Algimantas Paulauskas, Asta Danileviciutė, Tadas Povilaitis and Jonas Poderis
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Liāna Pļaviņa, Vitolds Mackēvičs, Silva Smagare, Andris Čakstiņš and Jekaterina Stankēviča
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Sammito, S., Gundlach, N