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Palaeopathological Evidence of Infectious Disease in a Skeletal Population from Late Medieval Riga, Latvia (15Th-17Th Centuries AD)

References Ascádi, G., Nemeskéri, J. (1970). History of Human Lifespan and Mortality. Akademiai Kiado, Budapest. 346 pp. Bergmann, A. (1988). Die lepra und ihre Gefahr für Rîga. Baltische Monatsschrift. 34, 336-355. Brennsohn, I. (1905). Die Aerzte Livlands von den ältesten Zeiten bis zur Gegenwart. Mitau (in German). 481 pp. Brooks, S., Suchey, J. M. (1990). Skeletal age determination based on the os pubis: A comparison of the Acsadi-Nemeskeri and Suchey-Brooks methods. Hum. Evol., 5, 227

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Morphological Characterisation And Molecular Sex Determination Of Human Remains From The 15th–17th Centuries In Latvia

Disease . Oxford: Academic Press. Bauer, C. M., Niederstätter, H., McGlynn, G., Stadler, H., Parson, W. (2013). Comparison of morphological and molecular genetic sex-typing on mediaeval human skeletal remains. Forensic Sci. Int. Genet. , 7 (6), 581–586. Brooks, S., Suchey, J. M. (1990). Skeletal age determination based on the os pubis: A comparison of the Acsadi-Nemeskeri and Suchey-Brooks methods. Hum. Evol. , 5, 227–238. Bruzek, J. (2002). A method for visual determination of sex, using the human hip bone. Amer. J. Phys. Anthropol. , 117

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Impact of Body Composition, Measured by Computed Tomography Scan, on Acute Pancreatitis Course

adipose depots. Obesity , 17 (5), 1062–1069. Blomgren, K. B., Sundström, A., Steineck, G., Wiholm, B. E., (2002). Obesity and treatment of diabetes with glyburide may both be risk factors for acute pancreatitis. Diabetes Care , 25 (2), 298–302. Brewster, D. J., Strauss, B. J., Crozier, T. M. (2014). Measuring visceral fat, subcutaneous fat and skeletal muscle area changes by computed tomography in acute pancreatitis: A retrospective, single-centre study. Crit. Care Resusc ., 16 (1), 42–47. Chalasani, N., Younossi, Z., Lavine, J. E., Diehl, A

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Identification of A Novel Mutation in RYR1 Gene in Malignant Hyperthermia-Like Patient's Family Members

Identification of A Novel Mutation in RYR1 Gene in Malignant Hyperthermia-Like Patient's Family Members

Malignant hyperthermia (MH) is a rare pharmacogenetic disorder with an autosomal dominant inheritance that presents as a hypermetabolic response in skeletal muscle to volatile anaesthetic (halothane, isoflurane, desflurane, sevoflurane) and the depolarising muscle relaxant succinil-choline and rarely to stresses such as vigorous exercise and heat. We investigated the relatives of an individual with suspected MH and found a novel mutation in RYR1 gene. The molecular analysis of RYR1 gene revealed a novel nucleotide substitution in exon 6 - G528T (Glu-176-Asp) in four family members of the patient. The in vitro contracture test (IVCT) according to the European Malignant Hyperthermia Group (EMHG) guidelines showed a MH susceptible phenotype in two tested family members.

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Modifications of nitric oxide production in rat tissues by ellagic acid, ipriflavone and resveratrol: a comparative study

Modifications of nitric oxide production in rat tissues by ellagic acid, ipriflavone and resveratrol: a comparative study

When administered as drugs or consumed as food components, polyphenolic compounds synthesised in plants interfere with intracellular signal transduction pathways, including pathways of nitric oxide (NO) synthase (NOS) expression. However, the effects of these compounds in vivo do not always correlate with NOS-inhibiting activities, as revealed in experiments with cultured cells. The goal of this work was to compare the effects of resveratrol, ellagic acid and ipriflavone on NO production in rat organs measured by means of ESR spectroscopy. All of the above compounds are known as inhibitors of iNOS expression. The presumed ability to decrease NO production was manifested only by ellagic acid; it decreased NO production in spleen of intact rats. Iproflavone and resveratrol even enhanced the lipopolyssacharides (LPS)-induced increase of NO production. Ipriflavone increased NO production in the brain cortex, cerebellum, liver, heart, kidneys, blood, lungs and skeletal muscles. Resveratrol produced a similar effect in all of the above organs, except kidneys, lungs and muscles. Taken together, our results suggest that modifications of NO level in tissues by a natural compound cannot be predicted from data about its effects on NOS expression or activity. This stresses the importance of direct measurements of NO in tissues.

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Assessment of firefighters-rescuers' work severity in relation with interaction between physical and mental load

. 200 pp. Mital, A. and Goviadaraj, M. (1999). Is it possible to have a single measure for all work? Int. J. Industr. Ergon. , 6 (3), 190-195. Roja, Z., Kalkis, V., Eglite, M., Vain, A., Kalkis, H. (2006). Assessment of skeletal muscles fatigue of road maintenance workers based on heart rate monitoring and myotonometry. J. Occup. Med. Toxicol. , 1 , 20-28. Vain, A., Kums, T. (2002). Criteria for Preventing Overtraining of the Musculoskeletal System of Gymnasts. Biol. Sport , 19 (4

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Electrophoretic pattern of the polypeptide component in the tight DNA-protein complexes in rat and chicken tissues and its partial characterisation in rat liver

Electrophoretic pattern of the polypeptide component in the tight DNA-protein complexes in rat and chicken tissues and its partial characterisation in rat liver

Tightly bound to DNA proteins (TBP) are a protein group that remain attached to DNA with covalent or non-covalent bonds after its deproteinisation. The distribution of TBP in genes reflects the type of cell differentiation. It has been hypothesised that TBP binding is involved in regulation of gene expression. Early studies reported uniformity of the TBPs from different sources. Later it was shown that TBPs obtained from DNA, isolated in mild conditions from evolutionary distant species, are different. Application of chloroform DNA extraction without use of externally added enzymes enabled us to reveal differences in the TBP spectrum in plant organs and changes of this spectrum in the course of plant development. The goal of this work was to study the electrophoretic pattern of the polypeptide component in the tight DNA-protein complexes in organs of animals: a mammal (rat) and a bird (chicken). Rat thymus TBPs were represented by 70 and 60 kDa proteins, and the same polypeptides were observed also in brain and skeletal muscles. Kidney TBPs were represented by 85, 70, 65, 60 and 37 kDa polypeptides; 85, 77, 70, 60, 50 and 37 kDa TBPs were characteristic of liver. Numerous minor peptides were observed in all samples studied. The spectrum of chicken liver and blood TBPs differed in distribution of proteins of 25-35 kDa. Mass-spectrometry of 14 bands from rat liver TBP gel revealed 43 different proteins. Chromatin modifying proteins and repair enzymes, transcription factors, serpins, ATPase, kinases and enzymes of ubiquitin-proteasome pathway were found among the TBPs. Thus, TBPs appear to be a vast protein group involved in several intranuclear processes. It is hypothesised that numerous functions ascribed to the nuclear matrix are performed in the TBP complexes.

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Spruce Needle Polyprenols Protect Against Atorvastatin-Induced Muscle Weakness and do not Influence Central Nervous System Functions in Rats

). Intolerance to statins: Mechanisms and management. Diabetes Care , 36 (2), S325–S330. Bizzarri, R., Cerbai, B., Signori, F. (2003). New perspectives for (S)-dolichol and (S)-nor dolichol synthesis and biological functions. Biogerontology , 4 (6), 353–363. Buhaescu, I., Izzedine, H. (2007). Mevalonate pathway: a review of clinical and therapeutical implications. Clin. Biochem. , 40 (9–10), 575–584. Camerino, G. M., Pellegrino, M. A., Brocca, L. (2011). Statin or fibrate chronic treatment modifies the proteomic profile of rat skeletal muscle

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Genetic Variability Associated with Angiotensin Converting Enzyme (ACE) Gene Polymorphism in Sportsmen Pursuing Different Sports

., Carr, J. (2000). Angiotensin I-converting enzyme: Genotype and disease associations. J. Mol. Diag. , 2 (3), 105--115. Folland, J., Leach, B., Little, T., Hawker, K., Myerson, S., Montgomery, H., Jones, D. (2000). Angiotensin-converting enzyme genotype affects the response of human skeletal muscle to functional overload. Exp. Physiol. , 85 , 575--579. Gayagay, G., Yu, B., Hambly, B., Boston, T., Hahn, A., Celermajer, D.S., Trent, R.J. (1998). Elite endurance athletes and the ACE I allele: The role of genes in

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Anthropometric Parameters and Biochemical Markers of Military Personnel Under the Influence of High Physical and Psychological Loads

, A., Okuyama, K., Yoshida, K., Kajimoto, Y. Y., Kuratsune, H., Kajimoto, O., Watanabe, Y. (2009). Mental and physical fatigue-related biochemical alterations. Nutrition , 25 (1), 51–57. Parkkari, J., Taanila, H.,Suni J., Mattila, V. M., Ohrankämmen, O., Vuorinen, P., Kannus, P., Pihlajamäki, H. (2011). Neuromuscular training with injury prevention counselling to decrease the risk of acute musculo skeletal injury in young men during military service: A population-based, randomised study. BMC Medicine , 9 , 35 (1–12). Sammito, S., Gundlach, N

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