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emerging as a new class of promising anticancer drugs. They show selective activity against certain cancer cells and low toxicity. Due to octahedral coordination sphere, rutheniumcomplexes have higher degree of specificity and size discrimination and exert lower toxicity and faster elimination from the body, in contrast to square planar geometry of platinum (II) compounds. Well known species NAMI-A and KP1019, which are currently in clinical trials, is opening new approaches in cancer treatment. The cellular targets of ruthenium compounds have not yet been identified