Search Results

1 - 4 of 4 items :

  • Laboratory Medicine x
Clear All
From influenza infection to anti-ADAMTS13 autoantibodies via cross-reactivity

://www.uniprot.org [ 30 , 31 ]. Protein primary sequences were decomposed into overlapping pentapeptides offset by one residue, ie, MGVPF, GVPFF, and VPFFS. Next, each pentapeptide was analyzed for occurrences in viral proteomes using Peptide Match program ( https://research.bioinformatics.udel.edu/peptidematch ) [ 32 ]. Proteomes from nine viruses were analyzed: influenza A virus, H1N1 (NCBI:txid211044), influenza A virus, H3N2 (NCBI:txid385580), influenza A virus, H5N1 (NCBI:txid93838), influenza A virus, H10N7 (NCBI:txid382838), influenza B virus (NCBI:txid518987), and influenza

Open access
Influenza and sudden unexpected death: the possible role of peptide cross-reactivity

peptide commonality between influenza hemagglutinin (HA) and the human proteome [ 27 , 28 , 29 ]. Such a peptide sharing might be potentially involved in neuropsychiatric disorders [ 28 , 29 ]. Instead, to the best of the current knowledge, no data have been reported on cross-reactivity as a possible autoimmune link between influenza infection and SUD. Using titin as a protein that, when altered, may associate with sudden death [ 30 , 31 , 32 , 33 , 34 ], this study specifically explored the peptide commonality between influenza viruses and titin, found viral vs

Open access
Molecular Pathogenesis of Liver Steatosis Induced by Hepatitis C Virus

Proteome Res 2012;11:2786-2797. 35. Tachi Y, Katano Y, Honda T, Hayashi K, Ishigami M, Itoh A, et al. Impact of amino acid substitutions in the hepatitis C virus genotype 1b core region on liver steatosis and hepatic oxidative stress in patients with chronic hepatitis C. Liver Int 2010;30:554-559. 36. Akuta N, Suzuki F, Hirakawa M, Kawamura Y, Yatsuji H, Sezaki H, et al. Amino acid substitutions in the hepatitis C virus core region of genotype 1b are the important predictor of severe insulin resistance in patients without cirrhosis and

Open access
Similarity of regulatory network between leukemia stem cells and normal hemopoietic stem cells

regulation of complex traits from expression data Bioinformatics. 2010 26 896 904 [18] Stelzl U., Worm U., Lalowski M., Haenig C., Brembeck F.H., Goehler H., et al., A human protein-protein interaction network: a resource for annotating the proteome, Cell., 2005, 122, 957-968. 10.1016/j.cell.2005.08.029 Stelzl U. Worm U. Lalowski M. Haenig C. Brembeck F.H. Goehler H. A human protein-protein interaction network: a resource for annotating the proteome Cell. 2005 122 957 968 [19] Ge H., Walhout A.J., Vidal M., Integrating ‘omic’ information: a bridge between genomics and

Open access