://www.uniprot.org [ 30 , 31 ]. Protein primary sequences were decomposed into overlapping pentapeptides offset by one residue, ie, MGVPF, GVPFF, and VPFFS. Next, each pentapeptide was analyzed for occurrences in viral proteomes using Peptide Match program ( https://research.bioinformatics.udel.edu/peptidematch ) [ 32 ].
Proteomes from nine viruses were analyzed: influenza A virus, H1N1 (NCBI:txid211044), influenza A virus, H3N2 (NCBI:txid385580), influenza A virus, H5N1 (NCBI:txid93838), influenza A virus, H10N7 (NCBI:txid382838), influenza B virus (NCBI:txid518987), and influenza
peptide commonality between influenza hemagglutinin (HA) and the human proteome [ 27 , 28 , 29 ]. Such a peptide sharing might be potentially involved in neuropsychiatric disorders [ 28 , 29 ]. Instead, to the best of the current knowledge, no data have been reported on cross-reactivity as a possible autoimmune link between influenza infection and SUD. Using titin as a protein that, when altered, may associate with sudden death [ 30 , 31 , 32 , 33 , 34 ], this study specifically explored the peptide commonality between influenza viruses and titin, found viral vs
Jun Cheng, Min Li, Ping Gao, Jin-ling Dong and Qi Wang
Proteome Res 2012;11:2786-2797.
35. Tachi Y, Katano Y, Honda T, Hayashi K, Ishigami M, Itoh A, et al. Impact of amino acid substitutions in the hepatitis C virus genotype 1b core region on liver steatosis and hepatic oxidative stress in patients with chronic hepatitis C. Liver Int 2010;30:554-559.
36. Akuta N, Suzuki F, Hirakawa M, Kawamura Y, Yatsuji H, Sezaki H, et al. Amino acid substitutions in the hepatitis C virus core region of genotype 1b are the important predictor of severe insulin resistance in patients without cirrhosis and
Zhi-Jian Li, Xing-Ling Sui, Xue-Bo Yang and Wen Sun
regulation of complex traits from expression data Bioinformatics. 2010 26 896 904
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