cytotoxic T lymphocytes and thus ultimately led to the apoptosis of hematopoietic cells.
Although understanding of the immune pathogenesis of SAA gradually improved after many years of research, which antigen activated mDCs and even T cells was still unclear. Actually, the immune-initiating antigen has become the focus of our further research. Newly, we have investigated the proteome of mDCs to further explore the possible antigen that leads to immune activation in SAA. Our research have demonstrated that there are changes in protein expression levels in the SAA group
Hongting Wang, Zuan-tao Lin, Yulin Yuan and Tianfu Wu
identifies biomarkers for acute rejection J Am Soc Nephrol 2010 21 646 53
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39 Wu T, Fu Y, Brekken D, Yan M, Zhou XJ, Vanarsa K, et al . Urine proteome scans uncover total urinary protease, prostaglandin D synthase, serum
Ovidiu Horea Bedreag, Alexandru Florin Rogobete, Dorel Sandesc, Carmen Alina Cradigati, Mirela Sarandan, Radu Nartita, Raluca Dumache, Mihai Mircea Diaconu and Marius Papurica
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Alexandra Lazăr, Anca Meda Georgescu, Alexander Vitin and Leonard Azamfirei
rearrangements. There are other “omes” zones including epigenome, transcriptome, proteome, metabolome though these are less commonly used. These zones contain tremendous information which could be utilised in treating the individual instead of the disease [ 10 ].
Personalised medicine is about using data on multiple scales, and having the ability to create a digital human mapping, with superimposed layers which includes, among other things, social graphs, biosensors, imaging for anatomy description, the characteristics of various “omics” such as genomics, DNA sequencing