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Clinical Proteomics in Kidney Disease: From Discovery to Clinical Application

diseases: unraveling the pathophysiology and biomarker discovery. Expert Rev Proteomics. 2005; 2(3): 349-366. 5. Andersen S, Mischak H, Zürbig P et al. Urinary proteome analysis enables assessment of renoprotective treatment in type 2 diabetic patients with microalbuminuria. BMC Nephrol. 2010; 11(1): 29- 6. Stalmach A, Albalat A, Mullen W, and Mischak H. Recent advances in capillary electrophoresis coupled to mass spectrometry for clinical proteomic applications. Electrophoresis. 2013; 34(11): 1452-1464. 7. Pontillo C, Filip S, Borras DM et al. CE

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Increased protein excretion, including albumin, by children of patients with urolithiasis

children, to validate these abnormalities for risk assessment, and to investigate further the urinary proteome and pathophysiology of urolithiasis. Materials and methods The present study, including assent forms for vulnerable participants (those aged 7-12 years, and 13-18 years old) was approved by Institutional Review Board of the Department for Development of Thai Traditional and Alternative Medicine as part of Ministry of Public Health, Thailand (approval No. RLC0029/55), and IRB of Sunpasit Prasong Hospital. We enrolled 116 participants in this study into 4

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Snake Venom Metalloproteinases

using a venom gland transcriptomics and proteomics approach. J Proteome Res. 2010;9(4):1882-1893. 26. Weldon CL, Mackessy SP. Biological and proteomic analysis of venom from the Puerto Rican Racer (Alsophis Portoricensis: Dipsadidae). Toxicon. 2010;55:558-569. 27. Georgieva D, Seifert J, Betzel C et al. Pseudechis australis venomics: adaptation for a defense against microbial pathogens and recruitment of body transferrin. 2011;10(5):2440-2464. 28. Petras D, Sanz L, Calvette JJ et al. Snake venomics of African spitting

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Chronic alcoholism-mediated metabolic disorders in albino rat testes

450 2E1 and its catalytic activity in rat testis. Biochem Biophys Res Commun 246: 578-583. Jove M, Ayala V, Ramirez-Nunez O, Naudi A, Cabre R, Spickett CM, Portero- Otin M, Pamplona R. (2013). Specifi c lipidome signatures in central nervous system from methionine-restricted mice. J Proteome Res 12: 2679-2689. Jung YS, Kim SJ, Kwon do Y, Jun DS, Kim YC. (2013). Signifi cance of alterations in the metabolomics of sulfur-containing amino acids during liver regeneration. Biochimie 95: 1605-1610. Jutte NH, Grootegoed JA

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Salivary Theranostics in Pediatric and Special Care Dentistry

Summary

Saliva as a microfluidic system offers numerous advantages for both general and oral health diagnostic and therapeutic procedures since its assembly is quick, stress-free, inexpensive and non-invasive. Moreover, saliva is frequently referred to as a mirror of the body due to the fact that it can reflect the physiological and pathological state of the body. More than a decade ago the term “Salivaomics” has been introduced with the aim of emphasizing the development of research, knowledge and applications of five salivary constituents: proteome, transcriptome, micro-RNA, metabolome, and microbiome. Contemporary oral health care delivery in pediatric and special care dentistry is focused toward the development of new diagnostic and therapeutical procedures that are essentially noninvasive due to common issue of intolerability to invasive procedures among these patients, with the possibility of increasing participation rates. Besides the criteria of being easily and non-invasive collected, there are additional standards that should be met before routine application in everyday clinical practice; the existence of specific biomarkers for a disease, and ability of having its biomarkers detected using present-day equipment. For example, there are recent suggestions that a salivary RNA panel could objectively differentiate children with autism spectrum disorder from their neurotypical peers. In addition, due to the ease of the administration, the oral cavity is an attractive site for the drug delivery systems development because through this route it is possible to realize mucosal and transmucosal, systemic effect. All these contemporary advances extended the salivary diagnostic approach from the oral to general health pointing towards a promising future of salivary diagnostics for personalized medicine devices.

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Dose-dependent effect of N′-Nitrosodiethylamine on hepatic architecture, RBC rheology and polypeptide repertoire in Wistar rats

REFERENCES Ahmad A, Afroz N, Gupta DU, Ahmad R. (2014a). Vitamin B12 supplement alleviates N′ -Nitrosodimethylamine-induced hepatic fibrosis in rats. Pharamaceut Biol 52 (4): 516–523. Ahmad A, Ahmad R. (2014b). A new method for proteome screening with two-dimensional Urea SDS-polyacrylamide gel electrophoresis. Organel Proteom 1 : 28–38. Ahmad A, Ahmad R. (2012a). Understanding the mechanism of hepatic fibrosis and potential therapeutic approaches. Saudi J Gatroenterol 18 (3): 155–167. Ahmad A, Fatima R, Maheshwari V, Ahmad R

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Salivary α-Amylase And Chromogranin A In Anxiety-Related Research

Abstract

Salivary α-amylase (sAA) and chromogranin A (sCgA) are at the forefront of current biochemical research on anxiety. Their use is being driven by the sudden surge of interest in “salivaomics,” a new field in medicine studying saliva’s genetic code, proteome and methabolom. Interestingly, it is not the primary functions of the enzyme and the protein, but the ingenious capture of their secondary ones (maintenance of the acid-alkaline balance and bactericidal / antifungal action) that allows for a swift, precise and pain-free measurement under physical and mental duress. Upon stimulation, sAA and sCgA are almost simultaneously released. Studying them allows a closer look at the autonomic nervous system (ANS) as opposed to the hypothalamic-pituitary-adrenal axis (HPA), which involves a long cascade of complex, hard to measure and interpret bio-chemical reactions.

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Nanoliposome Encapsulation with Donkey Milk Bioactive Proteins and Its Possible Application in Dermatology and Cosmetics

.1615/CritRevTherDrugCarrierSyst.v13.i3-4.30 4. Criscione A, Cunsolo V, Bordonaro S et al. Donkeys’ milk protein fraction investigated by electrophoretic methods and mass spectrometric analysis. Intern Dairy J 2009; 19: 190–7. https://doi.org/10.1016/j.idairyj.2008.10.015 5. Jirillo F, Magrone T. Anti-inflammatory and anti-allergic properties of donkey’s and goat’s milk. EndocrMetab Immune Disord Drug Targets 2014; 14: 27-37. https://doi.org/10.2174/1871530314666140121143747 6. Cunsolo V, Muccilli V, Fasoli Eet al. Poppea’s bath liquor: The secret proteome of she

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From influenza infection to anti-ADAMTS13 autoantibodies via cross-reactivity

://www.uniprot.org [ 30 , 31 ]. Protein primary sequences were decomposed into overlapping pentapeptides offset by one residue, ie, MGVPF, GVPFF, and VPFFS. Next, each pentapeptide was analyzed for occurrences in viral proteomes using Peptide Match program ( https://research.bioinformatics.udel.edu/peptidematch ) [ 32 ]. Proteomes from nine viruses were analyzed: influenza A virus, H1N1 (NCBI:txid211044), influenza A virus, H3N2 (NCBI:txid385580), influenza A virus, H5N1 (NCBI:txid93838), influenza A virus, H10N7 (NCBI:txid382838), influenza B virus (NCBI:txid518987), and influenza

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Zinc and Gold Complexes in the Treatment of Breast Cancer / Kompleksi Cinka I Zlata U Lecenju Karcinoma Dojke

the human genome. J Proteome Res. 5; 196-201. 16. Sekler I, Sensi SL, Hershfinkel M, Silverman WF. (2007). Mechanism and regulation of cellular zinc transport. Mol Med. 13; 337-343. 17. Gaither LA, Eide DJ. (2001). Eukaryotic zinc transporters and their regulation. Biometals. 14; 251-270. 18. McClelland RA, Manning DL, Gee JM, Wishler P, Robertson JF, Ellis IO, Blamey RW, Nicholson RI. (1998). Oestrogen-regulated gene sin breast cancer: Association of pLIV1 with response to endocrine therapy. Br _ Cancer. 77; 1653

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