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Clinical Proteomics in Kidney Disease: From Discovery to Clinical Application

diseases: unraveling the pathophysiology and biomarker discovery. Expert Rev Proteomics. 2005; 2(3): 349-366. 5. Andersen S, Mischak H, Zürbig P et al. Urinary proteome analysis enables assessment of renoprotective treatment in type 2 diabetic patients with microalbuminuria. BMC Nephrol. 2010; 11(1): 29- 6. Stalmach A, Albalat A, Mullen W, and Mischak H. Recent advances in capillary electrophoresis coupled to mass spectrometry for clinical proteomic applications. Electrophoresis. 2013; 34(11): 1452-1464. 7. Pontillo C, Filip S, Borras DM et al. CE

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Increased protein excretion, including albumin, by children of patients with urolithiasis

children, to validate these abnormalities for risk assessment, and to investigate further the urinary proteome and pathophysiology of urolithiasis. Materials and methods The present study, including assent forms for vulnerable participants (those aged 7-12 years, and 13-18 years old) was approved by Institutional Review Board of the Department for Development of Thai Traditional and Alternative Medicine as part of Ministry of Public Health, Thailand (approval No. RLC0029/55), and IRB of Sunpasit Prasong Hospital. We enrolled 116 participants in this study into 4

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Proteomics of the Spermatozoon

-791. 20. Pixton KL, Deeks ED, Flesch FM, et al. Sperm proteome mapping of a patient who experienced failed fertilization at IVF reveals altered expression of at least 20 proteins compared with fertile donors: case report. Hum Reprod. 2004; 19(6): 1438-1447.

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Human Seminal Plasma Proteome Study: a Search for Male Infertility Biomarkers

ABSTRACT

Seminal plasma is a potential source of biomarkers for many disorders of the male reproductive system including male infertility. Knowledge of the peptide and protein components of seminal fluid is accumulating especially with the appearance of highthroughput MS-based techniques. Of special interest in the field of male infertility biomarkers, is the identification and characterization of differentially expressed proteins in seminal plasma of men with normal and impaired spermatogenesis. However, the data obtained until now is still quite heterogeneous and with small percentage of overlap between independent studies. Extensive comparative analysis of seminal plasma proteome is still needed in order to establish a potential link between seminal plasma proteins and male infertility.

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Proteomics of heavy metal toxicity in plants

Proteome Res 2009;8:400-17. doi: 10.1021/pr800561r 27. Giordano PM, Mortvedt J, Mays A. Effect of municipal wastes on crop yields and uptake of heavy metals. J Environ Q u a l 1 9 7 5 ; 4 : 3 9 4 - 9 . d o i : 1 0 . 2 1 3 4 / jeq1975.00472425000400030024x 28. Islam E, Yang X, He Z, Mahmood Q. Assessing potential dietary toxicity of heavy metals in selected vegetables and food crops. J Zhejiang Univ Sci B 2007;8:1-13. doi: 10.1631/ jzus.2007.B0001 29. Fu J, Zhou Q, Liu J, Liu W, Wang T, Zhang Q, Jiang G. High levels of heavy

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Snake Venom Metalloproteinases

using a venom gland transcriptomics and proteomics approach. J Proteome Res. 2010;9(4):1882-1893. 26. Weldon CL, Mackessy SP. Biological and proteomic analysis of venom from the Puerto Rican Racer (Alsophis Portoricensis: Dipsadidae). Toxicon. 2010;55:558-569. 27. Georgieva D, Seifert J, Betzel C et al. Pseudechis australis venomics: adaptation for a defense against microbial pathogens and recruitment of body transferrin. 2011;10(5):2440-2464. 28. Petras D, Sanz L, Calvette JJ et al. Snake venomics of African spitting

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Chronic alcoholism-mediated metabolic disorders in albino rat testes

450 2E1 and its catalytic activity in rat testis. Biochem Biophys Res Commun 246: 578-583. Jove M, Ayala V, Ramirez-Nunez O, Naudi A, Cabre R, Spickett CM, Portero- Otin M, Pamplona R. (2013). Specifi c lipidome signatures in central nervous system from methionine-restricted mice. J Proteome Res 12: 2679-2689. Jung YS, Kim SJ, Kwon do Y, Jun DS, Kim YC. (2013). Signifi cance of alterations in the metabolomics of sulfur-containing amino acids during liver regeneration. Biochimie 95: 1605-1610. Jutte NH, Grootegoed JA

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Dose-dependent effect of N′-Nitrosodiethylamine on hepatic architecture, RBC rheology and polypeptide repertoire in Wistar rats

REFERENCES Ahmad A, Afroz N, Gupta DU, Ahmad R. (2014a). Vitamin B12 supplement alleviates N′ -Nitrosodimethylamine-induced hepatic fibrosis in rats. Pharamaceut Biol 52 (4): 516–523. Ahmad A, Ahmad R. (2014b). A new method for proteome screening with two-dimensional Urea SDS-polyacrylamide gel electrophoresis. Organel Proteom 1 : 28–38. Ahmad A, Ahmad R. (2012a). Understanding the mechanism of hepatic fibrosis and potential therapeutic approaches. Saudi J Gatroenterol 18 (3): 155–167. Ahmad A, Fatima R, Maheshwari V, Ahmad R

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Salivary Theranostics in Pediatric and Special Care Dentistry

Summary

Saliva as a microfluidic system offers numerous advantages for both general and oral health diagnostic and therapeutic procedures since its assembly is quick, stress-free, inexpensive and non-invasive. Moreover, saliva is frequently referred to as a mirror of the body due to the fact that it can reflect the physiological and pathological state of the body. More than a decade ago the term “Salivaomics” has been introduced with the aim of emphasizing the development of research, knowledge and applications of five salivary constituents: proteome, transcriptome, micro-RNA, metabolome, and microbiome. Contemporary oral health care delivery in pediatric and special care dentistry is focused toward the development of new diagnostic and therapeutical procedures that are essentially noninvasive due to common issue of intolerability to invasive procedures among these patients, with the possibility of increasing participation rates. Besides the criteria of being easily and non-invasive collected, there are additional standards that should be met before routine application in everyday clinical practice; the existence of specific biomarkers for a disease, and ability of having its biomarkers detected using present-day equipment. For example, there are recent suggestions that a salivary RNA panel could objectively differentiate children with autism spectrum disorder from their neurotypical peers. In addition, due to the ease of the administration, the oral cavity is an attractive site for the drug delivery systems development because through this route it is possible to realize mucosal and transmucosal, systemic effect. All these contemporary advances extended the salivary diagnostic approach from the oral to general health pointing towards a promising future of salivary diagnostics for personalized medicine devices.

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Identification and partial characterization of a sex specific protein in Koi carp (Cyprinus carpio haematopterus)

REFERENCES 1. Surinova S, Schiess R, Huttenhain R, Cerciello F, Wollscheid B, Aebersold R: On the Development of Plasma Protein Biomarkers. J Proteome Res 2011, 10:5-16. 2. Yilmaz M, Yilmaz R, Alas A: An electrophoretic taxonomic study on serum proteins of Acanthobrama marmid , Leuciscus cephalus , and Chondrostoma regium. EurAsia J BioSci 2007, 3:22-27. 3. Kumar LK, Gopalakrishnan A, Mohindra V, James PB: Identification of female specific protein in seabass, Lates calcarifer (Bloch). Ind J Fish 1999, 46:375-381. 4. Babin PJ

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