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From influenza infection to anti-ADAMTS13 autoantibodies via cross-reactivity

:// [ 30 , 31 ]. Protein primary sequences were decomposed into overlapping pentapeptides offset by one residue, ie, MGVPF, GVPFF, and VPFFS. Next, each pentapeptide was analyzed for occurrences in viral proteomes using Peptide Match program ( ) [ 32 ]. Proteomes from nine viruses were analyzed: influenza A virus, H1N1 (NCBI:txid211044), influenza A virus, H3N2 (NCBI:txid385580), influenza A virus, H5N1 (NCBI:txid93838), influenza A virus, H10N7 (NCBI:txid382838), influenza B virus (NCBI:txid518987), and influenza

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Influenza and sudden unexpected death: the possible role of peptide cross-reactivity

peptide commonality between influenza hemagglutinin (HA) and the human proteome [ 27 , 28 , 29 ]. Such a peptide sharing might be potentially involved in neuropsychiatric disorders [ 28 , 29 ]. Instead, to the best of the current knowledge, no data have been reported on cross-reactivity as a possible autoimmune link between influenza infection and SUD. Using titin as a protein that, when altered, may associate with sudden death [ 30 , 31 , 32 , 33 , 34 ], this study specifically explored the peptide commonality between influenza viruses and titin, found viral vs

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Boar sperm quality in relation to presence of sp32-like protein in spermatozoa - preliminary studies


The aim of the study was to analyse sperm proteomes of ejaculates from Polish Large White (PLW) and Polish Landrace (PL) boars and to identify differences which putatively influence semen quality. Spermatozoa protein profiles were analysed by electrophoretic methods followed by selected techniques to evaluate semen quality on the following factors: sperm motility, lipid peroxidation levels (MDA production), ATP content, activities of superoxide dismutase (SOD) and catalase (CAT), total antioxidant status (TAS), and total oxidant status (TOS) of seminal plasma. A protein with an estimated molecular weight of 30 kDa was found in spermatozoa of selected ejaculates. Mass spectrometry demonstrated that this polypeptide is most similar to proacrosin binding protein (sp32). The presence of the protein was more frequently observed in sperm extracts obtained in spring-summer period. Ejaculates containing sp32-like protein demonstrated significantly higher spermatozoa motility, lower inhibition of MDA production by seminal plasma, and higher SOD activity in seminal plasma. Boar semen which included sp32-like protein also demonstrated lower ATP levels in spermatozoa as well as higher TAS and lower TOS of seminal plasma, though the differences were not statistically significant. Ejaculates from PLW boars, with sp32-like protein present in sperm, were characterised by significantly higher sperm motility, lower ATP content in spermatozoa, and higher TAS of seminal plasma. The diminished parameters of semen quality were observed in ejaculates from PL boars that also contained the discussed protein, but the differences were not statistically significant. These findings suggest that the presence of sp32-like protein in boar spermatozoa could influence semen quality

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Antibacterial activity of selected snake venoms on pathogenic bacterial strains

) venoms: Taxonomic and toxino-logical implications. Rapid Commun Mass Spectrom. 2002;16:600–8. DOI: 10.1002/rcm.613 33. Petras D, Heiss P, Harrison RA, Süssmuth RD, Calvete JJ. Top-down venomics of the East African green mamba, Dendroaspis angusticeps, and the black mamba, Dendroaspis polylepis, highlight the complexity of their toxin arsenals. J Proteomics. 2016;146:148–64. DOI: 10.1016/j.jprot.2016.06.018 34. Huang HW, Liu BS, Chien KY, Chiang LC, Huang SY, Sung WC, et al. Cobra venom proteome and glycome determined from individual snakes of Naja atra

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Analysis of Nickel-Binding Proteins from Various Animal Sera

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Identification of novel pathways in pathogenesis of ketosis in dairy cows via iTRAQ/MS

generates oxidative stress in tissue sites for diabetic complications. Antioxid Redox Sign 2005, 7, 1543-1552 17. Raje C.I., Kumar S., Harle A., Nanda J.S., Raje M.: The macrophage cell surface glyceraldehyde-3-phosphate dehydrogenase is a novel transferrin receptor. J Biol Chem 2007, 282, 3252–3261. 18. Ramana K.V., Srivastava S.K.: Aldose reductase: a novel therapeutic target for inflammatory pathologies. Int J Biochem Cell Biol 2010, 42, 17–20. 19. Reinhardt T.A., Sacco R.E., Nonnecke B.J., Lippolis J.D.: Bovine milk proteome: quantitative changes in

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Implantable orthotopic bladder cancer model in Wistar rats: A pilot and feasibility study

Bacillus Calmette-Guerin at the proteome level in an in vivo rat model. Cancer Immunol Immunother. 2018;67(1):67-77. DOI: 10.1007/s00262-017-2063-2 6. Teke K, Ozkan TA, Cebeci OO, Yilmaz H, Keles ME, Ozkan L, et al. Preventive effect of intravesical ozone supplementation on n-methyl-n-nitrosourea-induced non-muscle invasive bladder cancer in male rats. Exp Anim. 2017;66(3):191-8. DOI: 10.1538/expanim.16-0093 7. Reis LO, Favaro WJ, Ferreira U, Billis A, Fazuoli MG, Cagnon VH. Evolution on experimental animal model for upper urothelium carcinogenesis. World J

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Effect of pregnancy and stage of lactation on energy processes in isolated blood cells of dairy cows

Proteome Res 2011, 10, 4252–4262. 16. Kuryl T., Adamowicz M., Dębski B., Bertrandt J., Martynik K.: Degradation of (9, 10)- 3 H-myristic acid by lymphocytes. Screening test of inherited disorders of activation, transport, and mitochondrial oxidation of fatty acids. Ateroskleroza 2001, 5, 23–27. 17. Lee D.N., Yen H.T., Shen T.F., Chen B.J.: Chromium-induced glucose uptake, superoxide anion production and phagocytosis in cultured pulmonary alveolar macrophages of weaning pigs. Biol Trace Elem Res 2000, 77, 53–64. 18. Manning N.J., Olpin S.E., Pollitt R

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Influence of α-lipoic acid on morphology of organs of rabbits fed a high fat diet with the addition of oxidised rapeseed oil

.H., Korczak J., Małecka M., Mildner – Szkudlarz S., Rudzińska M., Samotyja U., Zawirska-Wojtasiak R.: Oxidation of lipids in food. Pol J Food Nutr Sci 2004, 13/54, 87–100. 27. Wisniewski J.R., Friedrich A., Keller T., Mann M., Koepsell H.: The impact of high-fat diet on metabolism and immune defense in small intestine mucosa. J Proteome Res 2015, 14, 353−365. 28. Xu J., Zhou X., Gao H., Chang Ch., Deng Q., Huang Q., Ma J., Wan Z., Yang J., Huang F.: Micronutrients-fortified rapeseed oil improves hepatic lipid accumulation and oxidative stress in rats fed a high

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Phylogenetic study of H5 low pathogenic avian influenza viruses detected in wild birds in Poland in 2010−2015

.A., Kiselev O.I.: Molecular mechanisms enhancing the proteome of influenza A viruses: an overview of recently discovered proteins. Virus Res 2014, 185, 53–63. 29. Wille M., Tolf C., Avril A., Latorre-Margalef N., Wallerström S., Olsen B., Waldenström J.: Frequency and patterns of reassortment in natural influenza A virus infection in a reservoir host. Virology 2013, 443, 150–160.

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