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Minho, and supported by the Portuguese Foundation for Science and Technology, the Portuguese Ministry of Science, Technology and Higher Education through national funds and co-financed by FEDER through COMPETE2020 under the PT2020 Partnership Agreement (POCI-01-0145-FEDER-007653). References Ahmad MM. Psychometric evaluation of the Cognitive Appraisal of Health Scale with patients with prostate cancer. J Adv Nurs , 2005; 49(1): 78-86 Ahmad MM Psychometric evaluation of the Cognitive Appraisal of Health Scale with patients with prostate cancer J Adv Nurs 2005 49 1 78

onecarbon metabolism and prostate cancer risk. Am J Clin Nutr, 2006; 84: 929–935 Weinstein SJ Stolzenberg-Solomon R Pietinen P Taylor PR Virtamo J Albanes D Dietary factors of onecarbon metabolism and prostate cancer risk Am J Clin Nutr 2006 84 929 935 Weisberg I, Tran P, Christensen B, Sibani S, Rozen R. A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity. Mol Genet Metab , 1998; 64: 169–172 Weisberg I Tran P Christensen B Sibani S Rozen R A second genetic polymorphism in methylenetetrahydrofolate

Introduction According to the incidence of disease, lung cancer is the second-most frequent cancer after breast cancer in women and the second-most frequent cancer after prostate cancer in men ( Ferlay et al., 2015 ). Early diagnosis and new therapies together with the strong dynamics of newly occurring cases pertain to the growth of patients suffering from lung cancer. In Poland, there are over 22,000 registered patients with lung cancer (lung cancer in Poland – medical perspective). The majority of cases occur after the age of 50, and approximately 50% of cases