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3D polyelectrolyte scaffolds to mimic exocrine glands: a step towards a prostate-on-chip platform

appropriately to drugs used to treat prostate cancer ( 2 ) The use of organoids, as 3D culture models would provide even closer tissue-like conditions for studying drug reaction ( 3 ). Those types of 3D cell-culture systems provide information of cell responses that are measurable by imaging or spectroscopic techniques. The limitation of those 3D epithelial models for acinar structures is that it is not possible to access the luminal secretions to measure physiological responses in real-time and to identify new cancer biomarkers. The use of microfabricated systems, or

Open access
Biomarkers development for early detection of cancer: Reducing the burden of cancer in the ageing society

to satisfy this still unmet medical need. A novel source of biomarkers derives from the exploitation of the immune-surveillance against transformed malignant cells, since most, if not all, tumours are immunogenic. In many cancer biomarkers may be detected in the patients’ sera as immune complexes. These biomarkers are formed by immunoglobulins-M bound with low affinity and high avidity to markers expressed during cancer ( 4 ). Occurrence of immune complexes has been reported in several cases: prostate specific antigen (PSA)-IgM in prostate cancer( 5

Open access
Nanobiotechnology medical applications: Overcoming challenges through innovation

A review of drug delivery systems based on nanotechnology and green chemistry: green nanomedicine Int J Nanomed 2017 12 2957 2978 9 Dilnawaz F, Acharya S, Sahoo SK. Recent trends of nanomedicinal approaches in clinics. Int J Pharm 2018; 538:263-278. 10.1016/j.ijpharm.2018.01.016 29339248 Dilnawaz F Acharya S Sahoo SK Recent trends of nanomedicinal approaches in clinics Int J Pharm 2018 538 263 278 10 Paccez JD, et al. The receptor tyrosine kinase Axl is an essential regulator of prostate cancer proliferation and tumor growth and

Open access
Epilobium angustifolium L.: A medicinal plant with therapeutic properties

-360. 8. Vitalone A, Bordi F, Baldazzi C, Mazzanti G, Saso L, Tita B. Antiproliferative effect on a prostatic epithelial cell line (PZ-HPV-7) by Epilobium angustifolium L. Farmaco 2001; 56 (5-7): 483-489. 9. Vitalone A, Guizzetti M, Costa LG, Tita B. Extracts of various species of Epilobium inhibit proliferation of human prostate cells. J Pharm Pharmacol 2003; 55(5): 683-690. 10. Stolarczyk M, Naruszewicz M, Kiss AK. Extracts from Epilobium sp. herbs induce apoptosis in human hormone-dependent prostate cancer cells by activating the

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RHAMM-target peptides inhibit invasion of breast cancer cells

., Gerson R., White E., Rodriguez A., Walter J.C., Livingston D.M. The BRCA1/BARD1 heterodimer modulates ran-dependent mitotic spindle assembly. Cell. 2006, 127:539-552. 53. Gust K. M., Hofer M. D., Perner S.R., Chinnaiyan A. M., VaramballyS., Moller P., Rinnab L., Rubin M. A., Greiner J., Schmitt M., Kuefer R., and Ringhoffer M. RHAMM (CD168) is overexpressed at the protein level and may constitute an immunogenic antigen in advanced prostate cancer disease. Neoplasia. 2009, 11(9): 956-963. 54. Wang C., Thor A.D., Moore D.H., Zhao Y

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