Agnieszka Pluta, Tadeusz Robak, Kamil Brzozowski, Barbara Cebula-Obrzut, Agata Majchrzak, Piotr Pluta, Anna Szmigielska-Kapłon, Olga Grzybowska-Izydorczyk, Magdalena Czemerska, Piotr Stelmach, Piotr Smolewski and Agnieszka Wierzbowska
cell line to bleomycin treatment and that NAIP was shown to be downregulated by tumor suppressor p53 [ 32 ].
Chiu et al. showed using RT-PCR and Western blot approaches that NAIP mRNA and protein were expressed in prostaticcancer cells [ 32 ]. Moreover, the authors observed that increased NAIP expression significantly lowered the response to androgen therapy in an in vitro and in vivo mouse model [ 32 ]. It also corresponded with increased DNA-binding activity of NF-kappaB, an NAIP up-regulator, and resulted in treatment resistance [ 32 ]. In addition, a
Mateusz Nowicki, Piotr Stelmach and Anna Szmigielska-Kapłon
, Finetti F, et al. Linking microsomal prostaglandin E Synthase-1/PGE-2 pathway with miR-15a and -186 expression: Novel mechanism of VEGF modulation in prostatecancer. Oncotarget 2016;12;7(28):44350–64. doi: 10.18632/oncotarget.10051.
Terzuoli E Donnini S Finetti F Linking microsomal prostaglandin E Synthase-1/PGE-2 pathway with miR-15a and -186 expression: Novel mechanism of VEGF modulation in prostatecancer Oncotarget 2016 7 28 44350 64 10.18632/oncotarget.10051
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